Syrenity App for Depression

(SYRA Trial)

Age: 18+

Sex: Any

Trial Phase: Academic

Sponsor: Indiana University

Disqualifiers: Suicidal ideation

No Placebo Group All trial participants will receive the active study treatment (no placebo)

Compensation: Varies

Number of Visits: Unknown

Duration: 6 weeks

300 Participants Needed

Trial Summary

What is the purpose of this trial?

The goal of this clinical trial is to learn if the Syrenity mental health app reduces depressive symptoms when compared to a control condition. Secondarily, the trial will provide data on the usability and acceptability of the Syrenity app. The main questions it aims to answer are: Does Syrenity reduce self-reported depressive symptoms compared to a waiting list control? How usable is the Syrenity app?

Eligibility Criteria

This trial is for individuals in the United States who are experiencing symptoms of depression, as indicated by a score of 10 or higher on the PHQ-9 questionnaire. Participants must own and use an iPhone or Android smartphone.

Inclusion Criteria

PHQ-9 score greater than or equal to 10

Use an iPhone or Android

Residing in the United States

Exclusion Criteria

PHQ-9 item 9 score greater than or equal to 2

Timeline

Screening

Participants are screened for eligibility to participate in the trial

1-2 weeks

Treatment

Participants use the Syrenity mental health app, which includes active and passive interventions, for 6 weeks

6 weeks

Weekly surveys

Follow-up

Participants are monitored for safety and effectiveness after treatment

4 weeks

Treatment Details

Interventions

• Syrenity App

Trial Overview The Syrenity app is being tested to see if it can help reduce depressive symptoms compared to not using the app (waiting list control). The study will also gather feedback on how easy and enjoyable the app is to use.

Participant Groups

Group I: Syrenity App Experimental Treatment 1 Intervention

The Syrenity App is a mental health app that has been designed to help improve mental health and well-being. The content on the app was created using cognitive-behavioral therapy principles. It uses both active and passive interventions. Active interventions are interventions where the user engages with the app in a back and forth dialogue (e.g., a conversation about restructuring unhelpful thoughts). Passive interventions meanwhile consist of text or videos that the user can read or watch and do not require dialogue with the app.

Group II: Waiting list control Active Control 1 Intervention

Those assigned to the waiting list control condition will complete weekly surveys as those assigned to the intervention group but will not have access to the Syrenity platform until after the the 6-week trial period.

Who Is Running the Clinical Trial?

Indiana University

Lead Sponsor

Trials

1,063

Recruited

1,182,000+

Syra Health

Collaborator

Trials

1

Recruited

300+