Syrenity App for Depression

(SYRA Trial)

Age: 18+

Sex: Any

Trial Phase: Academic

Sponsor: Indiana University

Disqualifiers: Suicidal ideation

No Placebo Group All trial participants will receive the active study treatment (no placebo)

Compensation: Varies

Number of Visits: Unknown

Duration: 6 weeks

What You Need to Know Before You Apply

What is the purpose of this trial?

This trial explores whether a mental health app, called Syrenity, can reduce symptoms of depression. The main goal is to determine if users feel less depressed compared to those who don’t use the app immediately. Participants will either use the Syrenity app or join a waiting group that doesn’t use the app during the trial. The trial seeks individuals in the U.S. who have been feeling depressed and use a smartphone. As an unphased trial, this study offers a unique opportunity to contribute to innovative mental health solutions.

Do I have to stop taking my current medications for the trial?

The trial information does not specify whether you need to stop taking your current medications. It seems likely that you can continue them, but please confirm with the trial organizers.

What prior data suggests that the Syrenity App is safe for users?

Research shows that the Syrenity app is designed to improve mental health using principles from cognitive-behavioral therapy (CBT). It helps users change negative thoughts and behaviors to better manage depression and anxiety.

As a digital tool rather than a medication, the Syrenity app does not have the side effects associated with drugs. It focuses on in-app activities, such as conversations and videos, to support mental well-being, making it safe to use. Available for public download since December, no evidence of harmful effects has emerged from its use.

Additionally, Syrenity holds ISO certification, ensuring it meets high standards for securing user data. This is crucial for privacy and safety when handling sensitive mental health information.

Overall, Syrenity appears well-tolerated and safe for users seeking to manage their mental health. ^{1 2 3 4 5}

Why are researchers excited about this trial?

Unlike traditional treatments for depression, such as medication and face-to-face therapy, the Syrenity App offers a digital approach that integrates cognitive-behavioral therapy principles. This app is unique because it provides both active interventions, like interactive dialogues for restructuring unhelpful thoughts, and passive interventions, such as informative texts and videos. Researchers are excited about this treatment because it allows users to engage with mental health support at their own pace and convenience, potentially increasing accessibility and adherence for those who may have barriers to traditional therapy.

What evidence suggests that the Syrenity App is effective for reducing depressive symptoms?

Research has shown that the Syrenity app, available to participants in this trial, may help reduce symptoms of depression. In an early six-week study, users of the app reported feeling less depressed by the end. The app incorporates methods from cognitive-behavioral therapy (CBT), which is known to help with depression. These methods include activities that encourage positive thinking and content that aids in managing emotions. Although more research is needed, initial results suggest that Syrenity could be a useful tool for improving mental health. Participants in the waiting list control group will not access the Syrenity platform until after the six-week trial period. ^{3 4 6 7 8}

Are You a Good Fit for This Trial?

This trial is for individuals in the United States who are experiencing symptoms of depression, as indicated by a score of 10 or higher on the PHQ-9 questionnaire. Participants must own and use an iPhone or Android smartphone.

Inclusion Criteria

PHQ-9 score greater than or equal to 10

Use an iPhone or Android

Residing in the United States

Exclusion Criteria

PHQ-9 item 9 score greater than or equal to 2

Timeline for a Trial Participant

Screening

Participants are screened for eligibility to participate in the trial

1-2 weeks

Treatment

Participants use the Syrenity mental health app, which includes active and passive interventions, for 6 weeks

6 weeks

Weekly surveys

Follow-up

Participants are monitored for safety and effectiveness after treatment

4 weeks

What Are the Treatments Tested in This Trial?

Interventions

• Syrenity App

Trial Overview

The Syrenity app is being tested to see if it can help reduce depressive symptoms compared to not using the app (waiting list control). The study will also gather feedback on how easy and enjoyable the app is to use.

How Is the Trial Designed?

Group I: Syrenity App Experimental Treatment 1 Intervention

The Syrenity App is a mental health app that has been designed to help improve mental health and well-being. The content on the app was created using cognitive-behavioral therapy principles. It uses both active and passive interventions. Active interventions are interventions where the user engages with the app in a back and forth dialogue (e.g., a conversation about restructuring unhelpful thoughts). Passive interventions meanwhile consist of text or videos that the user can read or watch and do not require dialogue with the app.

Group II: Waiting list control Active Control 1 Intervention

Those assigned to the waiting list control condition will complete weekly surveys as those assigned to the intervention group but will not have access to the Syrenity platform until after the the 6-week trial period.

Who Is Running the Clinical Trial?

Indiana University

Lead Sponsor

Trials

1,063

Recruited

1,182,000+

Syra Health

Collaborator

Trials

1

Recruited

300+

Citations

1.

investing.com

investing.com/news/company-news/syrenity-app-shows-promise-in-depression-study-93CH-3874630

Syrenity app shows promise in depression study

Early results from the six-week study indicated a trend of symptom reduction among app users. Improvements in emotional regulation, such as ...

2.

dcpsych.org

dcpsych.org/content.aspx?page_id=22&club_id=984812&module_id=656568&rkey=20250218DE21008&filter=9054

Syra Health Announces Positive Preliminary Results ...

Syra Health Announces Positive Preliminary Results from Syrenity Study Led by Indiana University. CARMEL, Ind., Feb.

3.

syrahealth.com

syrahealth.com/press-releases/syra-health-launches-syrenity-an-evidencebased-app-for-managing-common-mental-health-conditions

Syra Health Launches Syrenity

Syrenity leverages a science-driven approach to address prevalent mental health challenges such as stress, anxiety, and depression, positioning ...

4.

ibj.com

ibj.com/articles/carmel-company-launches-mental-health-app

Carmel company launches mental health app

Lorenzo Lorenzo-Luaces said early results show people using Syrenity had lower depression scores after six weeks. But he added that mental ...

5.

finance.yahoo.com

finance.yahoo.com/news/syra-health-launches-syrenity-evidence-134500777.html

Syra Health Launches Syrenity: An Evidence-Based App ...

Syrenity leverages a science-driven approach to address prevalent mental health challenges such as stress, anxiety, and depression, positioning ...

6.

play.google.com

play.google.com/store/apps/details?id=com.syrahealth.syrenity&hl=en_US

Syrenity - Mental Health App

Start with scientifically backed assessments, including PHQ-9, GAD-7, and more, to gauge your mental health risk levels for conditions like ...

7.

syrahealth.com

syrahealth.com/behavioral-and-mental-health/syrenity

Telehealth for Mental Health

Syrenity transforms mental health care through personalized, proactive AI interventions, offering users customizable tools like assessments, cognitive therapy, ...

8.

stocktitan.net

stocktitan.net/news/SYRA/syra-health-earns-iso-27001-2022-certification-highlighting-company-bsc2wjwquj1u.html

Syra Health Earns ISO 27001:2022 Certification ...

New ISO certification validates Syra Health's advanced security measures for mental health data. Discover how their AI-powered platform ...