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Protein Supplement + Urolithin A for Muscle Atrophy

Led By Stuart Phillips
Research Sponsored by McMaster University
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Men aged 18-30 years
Be between 18 and 65 years old
Screening 3 weeks
Treatment Varies
Follow Up day 7, day 14, day 28, day 35; integrated synthesis rates reported for day 7-14, day 14-28; day 28-35
Awards & highlights

Study Summary

This trial will investigate if Urolithin A can help prevent muscle decline during illness or injury when people can't use their muscles.

Who is the study for?
This trial is for healthy, non-smoking men aged 18-30 with a BMI of 20-30 kg/m^2. Participants must not have orthopedic issues affecting the knee, gastrointestinal conditions, excessive alcohol use, or allergies to study ingredients. They can't be on certain medications or supplements that affect muscle health.Check my eligibility
What is being tested?
The study tests if adding Urolithin A to a protein supplement helps maintain muscle health during periods when participants can't use their muscles due to wearing a knee brace. It compares the effects of just protein supplementation against protein with Urolithin A.See study design
What are the potential side effects?
Potential side effects are not detailed in the provided information but could include digestive discomfort given that individuals with existing gastrointestinal conditions are excluded from participation.

Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below
I am a man between 18 and 30 years old.


Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~day 7, day 14, day 28, day 35; integrated synthesis rates reported for day 7-14, day 14-28; day 28-35
This trial's timeline: 3 weeks for screening, Varies for treatment, and day 7, day 14, day 28, day 35; integrated synthesis rates reported for day 7-14, day 14-28; day 28-35 for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Change in maximal mitochondrial respiration (rate of oxygen flux) and mitochondrial ADP [adenosine diphosphate] sensitivity (Oroboros O2k)
Secondary outcome measures
Muscle protein fractional synthetic rate
Muscle strength (Biodex)
Quadriceps muscle size

Trial Design

2Treatment groups
Experimental Treatment
Active Control
Group I: Protein supplement with Urolithin AExperimental Treatment1 Intervention
Group II: Protein supplementActive Control1 Intervention

Find a Location

Who is running the clinical trial?

McMaster UniversityLead Sponsor
880 Previous Clinical Trials
2,597,804 Total Patients Enrolled
Stuart PhillipsPrincipal InvestigatorMcMaster University

Media Library

Protein supplement (Other) Clinical Trial Eligibility Overview. Trial Name: NCT05814705 — N/A
Healthy Subjects Research Study Groups: Protein supplement with Urolithin A, Protein supplement
Healthy Subjects Clinical Trial 2023: Protein supplement Highlights & Side Effects. Trial Name: NCT05814705 — N/A
Protein supplement (Other) 2023 Treatment Timeline for Medical Study. Trial Name: NCT05814705 — N/A

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Does the research team have any age restrictions for participants?

"This medical trial has set a requirement that all participants must be older than 18 and younger than 30 in order to meet the inclusion criteria."

Answered by AI

Are new participants being accepted for this research initiative?

"Correct. Data hosted on clinicaltrials.gov reveals that this medical investigation, which was initially uploaded to the site in June 1st 2023, is presently accepting participants. 24 individuals need to be sourced from a single research centre."

Answered by AI

To what extent are participants engaged in this clinical trial?

"Affirmative. The clinical trial is actively recruiting participants, as displayed on the data hosted at clinicaltrials.gov which was last modified on April 14th 2023. This study requires 24 people to be enrolled from a single site."

Answered by AI

Who qualifies to partake in this experimental research?

"To qualify for the study, individuals must be within 18 to 30 years of age and have no major health issues. A total of 24 participants are being recruited."

Answered by AI
~2 spots leftby May 2024