~8 spots leftby Apr 2026

Protein Supplement + Urolithin A for Muscle Atrophy

BC
BC
Overseen ByBrad Currier
Age: 18 - 65
Sex: Male
Travel: May Be Covered
Time Reimbursement: Varies
Trial Phase: Academic
Waitlist Available
Sponsor: McMaster University
No Placebo Group

Trial Summary

What is the purpose of this trial?

There are times in life when people cannot use their muscles, such as during illness or injury. Muscle and mitochondria (the 'energy factory' in cells) health decline very quickly when people cannot use their muscles, but certain foods can help reduce these declines. Recent research suggests that Urolithin A, which is a natural compound that can be produced after eating pomegranates, nuts, and berries, improves muscle health. In this study, the investigators aim to investigate if a protein beverage (standard care during disuse) with or without Urolithin A can reduce or prevent the loss of muscle health while wearing a knee brace (muscle disuse).

Research Team

SP

Stuart Phillips

Principal Investigator

McMaster University

Eligibility Criteria

This trial is for healthy, non-smoking men aged 18-30 with a BMI of 20-30 kg/m^2. Participants must not have orthopedic issues affecting the knee, gastrointestinal conditions, excessive alcohol use, or allergies to study ingredients. They can't be on certain medications or supplements that affect muscle health.

Inclusion Criteria

No orthopedic issues that would preclude participation in the knee bracing protocol
Healthy, non-smoking
BMI between 20 and 30 kg/m^2
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Exclusion Criteria

I do not drink more than 21 units of alcohol a week or smoke.
Subject has any concurrent medical, orthopedic, or psychiatric requirements that, in the opinion of the investigators, would compromise their ability to comply with the study requirements
Any other condition that, in the opinion of the investigators, may adversely affect the subject's ability to complete the study or its measures or may pose a significant risk to the subject
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Treatment Details

Interventions

  • Protein supplement (Other)
  • Protein supplement with Urolithin A (Other)
Trial OverviewThe study tests if adding Urolithin A to a protein supplement helps maintain muscle health during periods when participants can't use their muscles due to wearing a knee brace. It compares the effects of just protein supplementation against protein with Urolithin A.
Participant Groups
2Treatment groups
Experimental Treatment
Active Control
Group I: Protein supplement with Urolithin AExperimental Treatment1 Intervention
Group II: Protein supplementActive Control1 Intervention

Find a Clinic Near You

Who Is Running the Clinical Trial?

McMaster University

Lead Sponsor

Trials
936
Recruited
2,630,000+