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Radioisotope Therapy

90Yttrium Colloid for Pituitary Cancer

Phase 3

Recruiting

Research Sponsored by David Clarke

Eligibility Criteria Checklist

Specific guidelines that determine who can or cannot participate in a clinical trial

Must have

Patients who require surgical intervention as determined by the treating neurosurgeon

Patients 17 years of age or older

Timeline

Screening 3 weeks

Treatment Varies

Follow Up within 3 weeks of treatment

Awards & highlights

Study Summary

This trial will test the safety and effectiveness of a new treatment for cystic pituitary lesions. The treatment is the stereotactic intracavitary instillation of 90yttrium colloid, and it will be compared to the other available treatment options.

Who is the study for?

This trial is for adults over 17 with cystic tumors in the pituitary region, confirmed by tests or imaging. Candidates must need surgery as per a neurosurgeon's assessment, be managed at the Halifax Neuropituitary Program surgical clinic, and agree to both surgery and study participation. Pregnant or breastfeeding individuals, those allergic to 90yttrium colloid, at high surgical risk, or with solid tumors cannot join.Check my eligibility

What is being tested?

The trial is testing an experimental treatment where a radioactive substance called 90yttrium colloid is placed directly into the cystic lesions of the pituitary area using stereotactic techniques. This approach aims to treat these challenging tumors without major risks associated with traditional surgeries or external radiation.See study design

What are the potential side effects?

While specific side effects are not listed here, potential risks may include reactions to the radiopharmaceutical agent (like allergies), complications from its direct placement into brain tissue (such as neurological deficits), and general risks related to invasive procedures.

Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below

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My neurosurgeon has decided I need surgery.

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I am 17 years old or older.

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I am willing to have surgery and understand the risks involved.

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I have a diagnosed cyst near my pituitary gland.

Timeline

Screening ~ 3 weeks3 visits

Treatment ~ Varies

Follow Up ~ within 3 weeks of treatment

Screening ~ 3 weeks

Treatment ~ Varies

Follow Up ~within 3 weeks of treatment

This trial's timeline: 3 weeks for screening, Varies for treatment, and within 3 weeks of treatment for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.

Primary outcome measures

Cyst shrinkage

Secondary outcome measures

Localization of intracystic 90yttrium colloid by PET-CT

Trial Design

1Treatment groups

Experimental Treatment

Group I: 90yttrium colloidExperimental Treatment1 Intervention

90 Yttrium colloid will be inserted into the cystic cavity. Based on clinical expertise, the treating neurosurgeon will determine the appropriate surgical procedure for each patient on an individual basis which will be reflected in the surgical consent the patient is presented and signs.

0 / 4Eligibility criteria met

Find a Location

Who is running the clinical trial?

David ClarkeLead Sponsor

1 Previous Clinical Trials

1 Total Patients Enrolled

Media Library

90yttrium colloid (Radioisotope Therapy) Clinical Trial Eligibility Overview. Trial Name: NCT02081768 — Phase 3

Pituitary Tumors Research Study Groups: 90yttrium colloid

Pituitary Tumors Clinical Trial 2023: 90yttrium colloid Highlights & Side Effects. Trial Name: NCT02081768 — Phase 3

90yttrium colloid (Radioisotope Therapy) 2023 Treatment Timeline for Medical Study. Trial Name: NCT02081768 — Phase 3

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

What is the regulatory status of 90yttrium colloid?

"There is some evidence of efficacy and numerous reports testifying to its safety, so our team has rated 90yttrium colloid as a 3 on our scale."

Answered by AI

Are people with the condition still eligible to participate in this experiment?

"That is correct, according to the clinicaltrials.gov website, this trial is still recruiting patients. The study was first posted on 6/1/2014 and was last updated recently on 1/27/2022. They are looking for a total of 40 participants at 1 location."

Answered by AI

What is the maximum sample size for this clinical trial?

"According to the listing on clinicaltrials.gov, this trial is open and actively recruiting patients. The study was first posted on June 1st, 2014 and has since been updated on January 27th, 2022. Currently, the trial is looking for 40 more patients at a single site."

Answered by AI

Recent research and studies

clinicaltrials.govStudy

90Yttrium Colloid for the Treatment of Cystic Sellar/Parasellar Tumors

David Clarke 2014. "90Yttrium Colloid for the Treatment of Cystic Sellar/Parasellar Tumors". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT02081768.