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Visual Deprivation - 10 days for Lazy Eye (LUMA Trial)

N/A
Waitlist Available
Led By Benjamin T Backus, PhD
Research Sponsored by State University of New York College of Optometry
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Be older than 18 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up 3 times during the 2 months before sequestration, 4 times during 12 months after sequestration
Awards & highlights

LUMA Trial Summary

Amblyopia is an impairment in spatial vision caused by asymmetry in the quality of visual input across the two eyes during childhood. It is difficult to treat in adulthood because the visual system becomes less "plastic" (able to learn) with age. The purpose of this study is to determine whether five to ten days of visual deprivation--living in complete darkness--can enhance plasticity in the visual cortex and thereby facilitate the learning that is needed to recover visual function in amblyopic adults.

LUMA Trial Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~three times during the 2 months before sequestration to establish baseline, and again after sequestration: once a week for 2 weeks, then once a month for 2 months, then once every 3 months until study completion (at approximately 1 year)
This trial's timeline: 3 weeks for screening, Varies for treatment, and three times during the 2 months before sequestration to establish baseline, and again after sequestration: once a week for 2 weeks, then once a month for 2 months, then once every 3 months until study completion (at approximately 1 year) for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Change from baseline in Backus Lab Stereoacuity Assessment
Change from baseline in acuity as measured using M&S Technologies automated ETDRS acuity test
Eye
Secondary outcome measures
Binocular motor fusion assessment
Other outcome measures
Daily self-report of visual hallucinations

LUMA Trial Design

2Treatment groups
Experimental Treatment
Active Control
Group I: Visual Deprivation - 10 daysExperimental Treatment2 Interventions
10 days of visual deprivation followed by vision training
Group II: Vision Training OnlyActive Control1 Intervention
Vision training without visual deprivation

Find a Location

Who is running the clinical trial?

State University of New York College of OptometryLead Sponsor
19 Previous Clinical Trials
1,128 Total Patients Enrolled
University of Maryland, College ParkOTHER
155 Previous Clinical Trials
45,657 Total Patients Enrolled
Nova Southeastern UniversityOTHER
89 Previous Clinical Trials
11,633 Total Patients Enrolled

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Who else is applying?

What state do they live in?
New Jersey
California
What portion of applicants met pre-screening criteria?
Met criteria
How many prior treatments have patients received?
0
What site did they apply to?
SUNY College of Optometry - Clinical Vision Research Center

Why did patients apply to this trial?

To see if this study helps. I’ve struggled with this my whole life.
PatientReceived 2+ prior treatments
Recent research and studies
clinicaltrials.govStudy
Light-deprivation Utilized to Mitigate Amblyopia
Ben Backus 2016. "Light-deprivation Utilized to Mitigate Amblyopia". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT02685423.
All > Amblyopia
~1 spots leftby Apr 2025
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