Allograft particles hydrated with rhPDGF for Osteoporosis

Unversity of Alabama at Birmingham, School of Dentistry, Birmingham, AL
Osteoporosis+1 More ConditionsAllograft particles hydrated with rhPDGF - Biological
Eligibility
18 - 99
All Sexes
What conditions do you have?
Select

Study Summary

This trial will compare two methods of increasing the size of the jawbone, using a resorbable barrier membrane and either a bone graft with saline or a growth factor called rhPDGF.

Eligible Conditions
  • Osteoporosis
  • Dental Implants

Treatment Effectiveness

Study Objectives

1 Primary · 1 Secondary · Reporting Duration: From baseline to 4 months

Month 4
Quantitative histomorphometric evaluation of new bone formation 4 months after GBR
Quantitative two- and three-dimensional radiographic comparison of dimensional changes 4 months using cone beam computed tomography (CBCT) and a virtual implant planning software, coDiagnostiX™

Trial Safety

Awards & Highlights

No Placebo Group
All patients enrolled in this trial will receive the new treatment.

Trial Design

2 Treatment Groups

Allograft particles hydrated in a conventional way with saline.
1 of 2
Allograft particles hydrated with rhPDGF
1 of 2

Active Control

Experimental Treatment

44 Total Participants · 2 Treatment Groups

Primary Treatment: Allograft particles hydrated with rhPDGF · No Placebo Group · N/A

Allograft particles hydrated with rhPDGF
Biological
Experimental Group · 1 Intervention: Allograft particles hydrated with rhPDGF · Intervention Types: Biological
Allograft particles hydrated in a conventional way with saline.
Biological
ActiveComparator Group · 1 Intervention: Allograft particles hydrated in a conventional way with saline. · Intervention Types: Biological

Trial Logistics

Trial Timeline

Screening: ~3 weeks
Treatment: Varies
Reporting: from baseline to 4 months

Who is running the clinical trial?

University of Alabama at BirminghamLead Sponsor
1,475 Previous Clinical Trials
2,246,183 Total Patients Enrolled
17 Trials studying Osteoporosis
550,945 Patients Enrolled for Osteoporosis

Eligibility Criteria

Age 18 - 99 · All Participants · 1 Total Inclusion Criteria

Mark “Yes” if the following statements are true for you:
You are missing one or more teeth in a specific area of your mouth and require dental implants to replace them.

Who else is applying?

What state do they live in?
Georgia16.7%
New York16.7%
Florida8.3%
Other58.3%
How old are they?
18 - 65100.0%
What site did they apply to?
Unversity of Alabama at Birmingham, School of Dentistry100.0%
What portion of applicants met pre-screening criteria?
Met criteria100.0%
Why did patients apply to this trial?
  • "I don’t know if I am contacting the right people but I’m in desperate need of dental implants. It’s to the point where I don’t smile at all to embarrassing and I can’t afford them."
  • "I am ready for a new smile. I am trying to further my career but looking angry due to a closed mouth isn't helping. I love when I'm told I'm beautiful but I hate smiling when It's told. I am not to far from Birmingham and I would love to be considered. Low income single mother raising two boys and being behind a computer for minimum pay trying to afford dental implants has been rough for at least 5 years plus keeping up with the economy"
How many prior treatments have patients received?
0100.0%

How responsive is this trial?

Average response time
  • < 2 Days
Most responsive sites:
  1. Unversity of Alabama at Birmingham, School of Dentistry: < 48 hours
Typically responds via
Email100.0%

Frequently Asked Questions

Is eligibility for enrollment in this trial restricted to individuals over 25 years of age?

"Compatible with the requirements for taking part in this trial, individuals must be a minimum of 18 years old and no older than 99." - Anonymous Online Contributor

Unverified Answer

How can I become part of this medical research?

"This medical study seeks 44 volunteers, aged 18 to 99 years old and suffering from alopecia. Individuals must also be patients of the UAB Dental School with a need for implants in at least one quadrant of the mouth." - Anonymous Online Contributor

Unverified Answer

Is this experiment presently welcoming participants?

"Indeed, the information found on clinicaltrials.gov confirms that this medical research program is actively enrolling patients; it was first posted to the website on August 11th 2021 and has since been updated lastly on August 24th 2022. A total of 44 participants are needed for participation at a single site." - Anonymous Online Contributor

Unverified Answer

What is the upper bound of participants in this research endeavor?

"Affirmative. Clinicaltrials.gov attests that this study is actively recruiting for 44 patients at 1 site, which was initially posted on August 11th 2021 and revised recently on August 24th 2022." - Anonymous Online Contributor

Unverified Answer
Please Note: These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.