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Diagnostic Test

Low-Dose CT Scans for Testicular Cancer

N/A
Waitlist Available
Led By Peter Chung
Research Sponsored by University Health Network, Toronto
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Phase A: Newly diagnosed testicular germ cell testicular cancer (GCT) with no clinical or tumour marker evidence of metastases
Phase A: ECOG performance status 0 or 1
Timeline
Screening 3 weeks
Treatment Varies
Follow Up 9 years
Awards & highlights

Study Summary

This trial is testing whether low-dose CT scans are as effective as standard CT scans in detecting disease recurrence in patients with primary germ cell cancer of the testicles.

Who is the study for?
This trial is for individuals with Stage I testicular cancer who are in their first year of surveillance for non-seminoma or within the first two years for seminoma. They must have a good performance status, meaning they're fully active or restricted in physically strenuous activity but can do light work.Check my eligibility
What is being tested?
The study is testing if low-dose computed tomography (LDCT) scans are as effective as standard CT scans at spotting cancer recurrence while reducing radiation exposure over up to ten years of patient follow-up.See study design
What are the potential side effects?
While LDCT itself doesn't have side effects, repeated exposure to even low doses of radiation may slightly increase the risk of developing secondary cancers later on.

Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below
Select...
I have newly diagnosed testicular cancer with no signs it has spread.
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I am fully active or restricted in physically strenuous activity but can do light work.

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~9 years
This trial's timeline: 3 weeks for screening, Varies for treatment, and 9 years for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Difference in size of the retroperitoneal lymph node mass
Secondary outcome measures
Amount of false positive rate of LDCTs
Amount of prospective documentation of treatment for testicular germ cell cancer relapse
Amount of prospective identification of first modality to detect relapse
+5 more

Trial Design

1Treatment groups
Experimental Treatment
Group I: Patients with testicular germ cell cancerExperimental Treatment1 Intervention
Patients with testicular germ cell cancer who have either been newly diagnosed, or have stage I cancer already on surveillance program will undergo conventional and low dose CT. Based on the imaging, they may undergo a surveillance program using low-dose CT.

Find a Location

Who is running the clinical trial?

University Health Network, TorontoLead Sponsor
1,468 Previous Clinical Trials
484,268 Total Patients Enrolled
2 Trials studying Testicular Cancer
224 Patients Enrolled for Testicular Cancer
Peter ChungPrincipal InvestigatorThe Princess Margaret Cancer Foundation

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.
Recent research and studies
European Urology OncologyJournal
Detection of Relapse by Low-dose Computed Tomography During Surveillance in Stage I Testicular Germ Cell Tumours
Chung, Peter, Martin E. O’Malley, Michael A.S. Jewett, Philippe L. Bedard, Tony Panzarella, Jeremy Sturgeon, Malcolm J. Moore, et al.. 2019. “Detection of Relapse by Low-dose Computed Tomography During Surveillance in Stage I Testicular Germ Cell Tumours”. European Urology Oncology. Elsevier BV. doi:10.1016/j.euo.2018.08.031.
clinicaltrials.govStudy
Low-Dose CT - Stage I Testicular Cancer
2005. "Low-Dose CT - Stage I Testicular Cancer". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT03142802.
All > Testicular Cancer
~13 spots leftby Apr 2025
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