This trial is evaluating whether DOTATATE PET-CT will improve 2 primary outcomes and 2 secondary outcomes in patients with Cushing's Syndrome. Measurement will happen over the course of Ongoing.
This trial requires 80 total participants across 1 different treatment group
This trial involves a single treatment. DOTATATE PET-CT is the primary treatment being studied. Participants will all receive the same treatment. There is no placebo group. The treatments being tested are in Phase 2 and have already been tested with other people.
"The exact underlying mechanism is still unknown, as well as the factors that activate this syndrome. However, the cushing hormones, ACTH and cortisol do play an important role in the cushing syndrome. Patients with these hormones must be treated in order to avoid severe complications of CS." - Anonymous Online Contributor
"Cushing-related adrenal insufficiency occurs in about half a million women and 25–50% of men aged 50 and older, as part of normal aging. Symptoms of Cushing-related adrenal insufficiency include weight changes, increased fatigue, muscle aches, joint pains, weakness, and problems concentrating and memory. More serious, sometimes life-threatening, symptoms include high blood glucose, low blood potassium and loss of blood pressure and heart rate that can lead to fainting, convulsions, and death without treatment. The hypothalamic-pituitary-adrenal axis regulates the body's immune system and stress, in part by secreting hormones that modify the body's physiology." - Anonymous Online Contributor
"This review concludes cushing syndrome can be successfully treated with long-term glucocorticoid replacement therapy. The success rate is high (90%). Despite recent advances in glucocorticoid replacement therapy, long-term glucocorticoid replacement therapy remains one of the best available treatments for treatment of CS in most patients." - Anonymous Online Contributor
"As many as one fifth of the community sample had a clinical diagnosis of hypercorticosteroidism. This is an important and neglected disorder; thus a simple clinical history and measurement would be very helpful in early diagnosis. The prevalence of hypothyroidism was higher than expected (10-20 % vs 5-10 %), whereas the prevalence of Cushing syndrome was lower than expected." - Anonymous Online Contributor
"Cushing syndrome is a complex condition and requires individualized treatments. Common interventions can include medication, surgery, chemotherapy or radiation therapy. However, all treatments to alleviate symptoms and correct the underlying hypercortisolism are needed. In severe and refractory cases, it is necessary to discuss the possibility of radioactive adrenalectomy or bilateral adrenalectomy. These alternative treatments can improve quality of life for patients. Appropriate social support is vital for patients with hypercortisolism, since mental distress can often be exacerbated by the condition." - Anonymous Online Contributor
"About 28,000 US children are diagnosed with Cushing syndrome a year; a significant percentage of cases being missed. This makes up one out of twenty-one children." - Anonymous Online Contributor
"The dotatate pet-ct is suitable for patients who have severe or refractory hypercalcemia due to metastatic or indolent carcinoma(s) of the parathyroid gland, breast, or multiple endocrine tumors." - Anonymous Online Contributor
"We conclude that a 6-week treatment with dotatate pet-ct is effective in the treatment of gastric adenocarcinomas, especially in patients with c-KIT overexpression, and may be a better alternative to current standard therapies." - Anonymous Online Contributor
"If you're a woman, you have a higher chance of getting cushing syndrome in your 50s and 60s. If this is your age group, contact your doctor or ask a nurse if you suspect you might have it later in life. A healthy lifestyle can help postpone and/or decrease the date that Cushing's happens in your life." - Anonymous Online Contributor
"In the last 15 years the number of PET/CT applications has doubled every 3 years, thus the number of indications has also doubled in the same time span. Among others the first indications should be excluded benign tumors and the second should be FDG PET/CT in primary staging of tumor of unknown origin. Results from a recent paper points out a significant improvement of the diagnostic accuracy on the basis of DPT PET/CT in comparison with classical imaging, mainly in the patients with thyroid nodule on the first line." - Anonymous Online Contributor
"DPCT can be an alternative for TIO management, improving QoL of patients with cNS, especially for those with hCG >1000 mIU/L. However, this therapy should be carefully prescribed to ensure no adverse side effect such as hypotension caused by hypervolemic hyponatremia." - Anonymous Online Contributor
"Recent developments in dotatate pet-ct, especially with the use of dotatase in the formulation, is promising and has the potential to make a substantial impact on cancer management in future years." - Anonymous Online Contributor