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Foradil
Asthma, Bronchoconstriction, maintenance therapy + 6 more
Treatment
20 Active Studies for Foradil
Treatment for
Asthma
What is Foradil
FormoterolThe Generic name of this drug
Treatment SummaryFormoterol is an inhalable medication used to treat COPD and asthma. It works by relaxing the bronchial muscles in the lungs, making it easier to breathe. The effects of this drug can be felt in a few minutes and can last up to 12 hours. Formoterol is available on its own or combined with corticosteroids and/or long-acting muscarinic antagonists. It is prescribed both as a rescue medication and as a maintenance medication.
Foradilis the brand name
Foradil Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Foradil
Formoterol
2001
37
Effectiveness
How Foradil Affects PatientsFormoterol relaxes the muscles in the lungs, allowing more air to flow in and out. It starts to work quickly (2-3 minutes) and provides relief for up to 12 hours. It is important to note that taking formoterol without other medications (like inhaled corticosteroids) can increase the risk of death due to asthma.
How Foradil works in the bodyFormoterol is a long-acting medication that helps to relax the muscles in the airways, making it easier to breathe. It works by targeting beta<sub>2</sub>-adrenergic receptors, which are found in the lungs. It also has some activity on beta<sub>1</sub> and beta<sub>3</sub> receptors found in the heart, but is much more effective at targeting the beta<sub>2</sub> receptors in the lungs. When formoterol binds to these receptors, it stimulates an enzyme called adenylyl cyclase which helps to relax the muscles in
When to interrupt dosage
The prescribed measure of Foradil is dependent upon the diagnosed condition, including Bronchial Asthma, Bronchoconstriction and Asthma. The amount of dosage depends on the technique of delivery (e.g. Solution - Respiratory (inhalation) or Aerosol) detailed in the table below.Condition
Dosage
Administration
Chronic Obstructive Pulmonary Disease
, 0.012 mg, 0.005 mg, 0.02 mg/mL, 0.0048 mg, 0.0045 mg, 0.009 mg, 0.012 mg/pump actuation, 0.0058 mg/pump actuation, 0.006 mg/pump actuation, 0.005 mg/pump actuation
, Respiratory (inhalation), Capsule, Capsule - Respiratory (inhalation), Powder, Powder - Respiratory (inhalation), Aerosol, metered, Aerosol, metered - Respiratory (inhalation), Powder, metered, Powder, metered - Respiratory (inhalation), Aerosol, Aerosol - Respiratory (inhalation), Solution, Solution - Respiratory (inhalation)
Asthma
, 0.012 mg, 0.005 mg, 0.02 mg/mL, 0.0048 mg, 0.0045 mg, 0.009 mg, 0.012 mg/pump actuation, 0.0058 mg/pump actuation, 0.006 mg/pump actuation, 0.005 mg/pump actuation
, Respiratory (inhalation), Capsule, Capsule - Respiratory (inhalation), Powder, Powder - Respiratory (inhalation), Aerosol, metered, Aerosol, metered - Respiratory (inhalation), Powder, metered, Powder, metered - Respiratory (inhalation), Aerosol, Aerosol - Respiratory (inhalation), Solution, Solution - Respiratory (inhalation)
Bronchoconstriction
, 0.012 mg, 0.005 mg, 0.02 mg/mL, 0.0048 mg, 0.0045 mg, 0.009 mg, 0.012 mg/pump actuation, 0.0058 mg/pump actuation, 0.006 mg/pump actuation, 0.005 mg/pump actuation
, Respiratory (inhalation), Capsule, Capsule - Respiratory (inhalation), Powder, Powder - Respiratory (inhalation), Aerosol, metered, Aerosol, metered - Respiratory (inhalation), Powder, metered, Powder, metered - Respiratory (inhalation), Aerosol, Aerosol - Respiratory (inhalation), Solution, Solution - Respiratory (inhalation)
maintenance therapy
, 0.012 mg, 0.005 mg, 0.02 mg/mL, 0.0048 mg, 0.0045 mg, 0.009 mg, 0.012 mg/pump actuation, 0.0058 mg/pump actuation, 0.006 mg/pump actuation, 0.005 mg/pump actuation
, Respiratory (inhalation), Capsule, Capsule - Respiratory (inhalation), Powder, Powder - Respiratory (inhalation), Aerosol, metered, Aerosol, metered - Respiratory (inhalation), Powder, metered, Powder, metered - Respiratory (inhalation), Aerosol, Aerosol - Respiratory (inhalation), Solution, Solution - Respiratory (inhalation)
Asthma, Exercise-Induced
, 0.012 mg, 0.005 mg, 0.02 mg/mL, 0.0048 mg, 0.0045 mg, 0.009 mg, 0.012 mg/pump actuation, 0.0058 mg/pump actuation, 0.006 mg/pump actuation, 0.005 mg/pump actuation
, Respiratory (inhalation), Capsule, Capsule - Respiratory (inhalation), Powder, Powder - Respiratory (inhalation), Aerosol, metered, Aerosol, metered - Respiratory (inhalation), Powder, metered, Powder, metered - Respiratory (inhalation), Aerosol, Aerosol - Respiratory (inhalation), Solution, Solution - Respiratory (inhalation)
Chronic Obstructive Airway Disease
, 0.012 mg, 0.005 mg, 0.02 mg/mL, 0.0048 mg, 0.0045 mg, 0.009 mg, 0.012 mg/pump actuation, 0.0058 mg/pump actuation, 0.006 mg/pump actuation, 0.005 mg/pump actuation
, Respiratory (inhalation), Capsule, Capsule - Respiratory (inhalation), Powder, Powder - Respiratory (inhalation), Aerosol, metered, Aerosol, metered - Respiratory (inhalation), Powder, metered, Powder, metered - Respiratory (inhalation), Aerosol, Aerosol - Respiratory (inhalation), Solution, Solution - Respiratory (inhalation)
Asthma
, 0.012 mg, 0.005 mg, 0.02 mg/mL, 0.0048 mg, 0.0045 mg, 0.009 mg, 0.012 mg/pump actuation, 0.0058 mg/pump actuation, 0.006 mg/pump actuation, 0.005 mg/pump actuation
, Respiratory (inhalation), Capsule, Capsule - Respiratory (inhalation), Powder, Powder - Respiratory (inhalation), Aerosol, metered, Aerosol, metered - Respiratory (inhalation), Powder, metered, Powder, metered - Respiratory (inhalation), Aerosol, Aerosol - Respiratory (inhalation), Solution, Solution - Respiratory (inhalation)
Chronic Obstructive Airway Disease
, 0.012 mg, 0.005 mg, 0.02 mg/mL, 0.0048 mg, 0.0045 mg, 0.009 mg, 0.012 mg/pump actuation, 0.0058 mg/pump actuation, 0.006 mg/pump actuation, 0.005 mg/pump actuation
, Respiratory (inhalation), Capsule, Capsule - Respiratory (inhalation), Powder, Powder - Respiratory (inhalation), Aerosol, metered, Aerosol, metered - Respiratory (inhalation), Powder, metered, Powder, metered - Respiratory (inhalation), Aerosol, Aerosol - Respiratory (inhalation), Solution, Solution - Respiratory (inhalation)
Pulmonary Disease, Chronic Obstructive
, 0.012 mg, 0.005 mg, 0.02 mg/mL, 0.0048 mg, 0.0045 mg, 0.009 mg, 0.012 mg/pump actuation, 0.0058 mg/pump actuation, 0.006 mg/pump actuation, 0.005 mg/pump actuation
, Respiratory (inhalation), Capsule, Capsule - Respiratory (inhalation), Powder, Powder - Respiratory (inhalation), Aerosol, metered, Aerosol, metered - Respiratory (inhalation), Powder, metered, Powder, metered - Respiratory (inhalation), Aerosol, Aerosol - Respiratory (inhalation), Solution, Solution - Respiratory (inhalation)
Warnings
Foradil has four contraindications and should not be utilized while experiencing any of the conditions presented in the table below.Foradil ContraindicationsCondition
Risk Level
Notes
Severe Hypersensitivity Reactions
Do Not Combine
Formoterol may interact with Pulse Frequency
Status Asthmaticus
Do Not Combine
Asthma
Do Not Combine
Status Asthmaticus
Do Not Combine
Common Foradil Drug Interactions
Drug Name
Risk Level
Description
Amoxapine
Major
The metabolism of Amoxapine can be decreased when combined with Formoterol.
Astemizole
Major
The metabolism of Astemizole can be decreased when combined with Formoterol.
Clomipramine
Major
The metabolism of Clomipramine can be decreased when combined with Formoterol.
Cyclophosphamide
Major
The metabolism of Cyclophosphamide can be decreased when combined with Formoterol.
Dacomitinib
Major
The metabolism of Dacomitinib can be decreased when combined with Formoterol.
Foradil Toxicity & Overdose RiskThe lowest toxic dose of formoterol in rats is 3130mg/kg. Overdosing on formoterol can cause symptoms such as chest pain, high or low blood pressure, fast heartbeat, abnormal heart rhythm, anxiety, headache, shaking, and seizures. Lab tests may show low potassium levels, high blood sugar, and an acidic balance in the body. Treatment for overdosing on formoterol should focus on stabilizing the patient and checking the heart rate. A beta-blocker that affects only the heart may be used to reduce the effects of too much adrenaline in the body if necessary.
Foradil Novel Uses: Which Conditions Have a Clinical Trial Featuring Foradil?
251 active studies are currently being conducted to determine the potential of Foradil in alleviating Chronic Obstructive Pulmonary Disease (COPD), Moderate to Severe COPD and Chronic Obstructive Airway Disease.Condition
Clinical Trials
Trial Phases
Chronic Obstructive Pulmonary Disease
78 Actively Recruiting
Phase 3, Phase 1, Phase 2, Not Applicable, Early Phase 1, Phase 4
Chronic Obstructive Airway Disease
7 Actively Recruiting
Not Applicable, Phase 4
maintenance therapy
0 Actively Recruiting
Chronic Obstructive Airway Disease
0 Actively Recruiting
Pulmonary Disease, Chronic Obstructive
0 Actively Recruiting
Asthma, Exercise-Induced
0 Actively Recruiting
Asthma
1 Actively Recruiting
Phase 4
Bronchoconstriction
0 Actively Recruiting
Asthma
86 Actively Recruiting
Phase 4, Early Phase 1, Phase 2, Not Applicable, Phase 1, Phase 3
Foradil Reviews: What are patients saying about Foradil?
5Patient Review
4/14/2012 This is the only treatment I've found that actually relieves my exercise-induced asthma attacks and symptoms.
5Patient Review
2/19/2011 This medication has been a great help for my breathing and emphysema.
5Patient Review
2/5/2011 This treatment really allows me to do more than before.
5Patient Review
9/30/2009 I've used this medication for years without any issues, but recently I started having to use my rescue inhaler more frequently while exercising. I'm hoping it's just a cold or something, but I'm going to talk to my doctor about it.
5Patient Review
5/3/2013 Foradil is more effective than the CCs, in my opinion.
Patient Q&A Section about foradil
These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.How quickly does foradil work?
"Formoterol should begin to work within 1-3 minutes after use. Those whose asthma is controlled by occasional use of short-acting bronchodilators should not use Formoterol. It is not meant to be used as a "rescue" medication to relieve current asthma symptoms."
Answered by AI
Why was foradil discontinued?
"The FDA has announced that Foradil Aerolizer, manufactured by Merck, has been discontinued. The decision to discontinue the product is for business reasons and not due to any safety or efficacy concerns."
Answered by AI
What is the generic name for Foradil?
"Foradil Aerolizer is a long-acting bronchodilator that is used to prevent bronchospasm in people with reversible obstructive airways disease, including symptoms of nighttime asthma."
Answered by AI
Clinical Trials for Foradil
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