THS for COPD
What You Need to Know Before You Apply
What is the purpose of this trial?
This trial aims to determine if switching from cigarettes to a new product called THS (a tobacco heating system) can improve symptoms and lung function in people with COPD. It compares two groups: one continues smoking cigarettes, while the other switches to THS. Individuals who have smoked cigarettes for at least 10 years, have been diagnosed with COPD, and experience frequent coughing may be suitable candidates for this trial. As an unphased trial, this study provides a unique opportunity to explore new methods for managing COPD symptoms.
Will I have to stop taking my current medications?
The trial requires that you stop using certain medications, such as ACE inhibitors and opioids, before participating. If you're on these medications, you must stop using ACE inhibitors at least 4 weeks and opioids at least 1 week before the screening.
Is there any evidence suggesting that this trial's treatments are likely to be safe?
Research has shown that THS treatments for COPD are generally safe. Short-term studies consistently found that these treatments do not significantly tighten the airways, which benefits people with COPD. Although specific safety data for THS is not available, similar treatments are usually well-tolerated. Prospective trial participants may find this information reassuring. It is important to consult a doctor to understand personal implications.12345
Why are researchers excited about this trial?
Most treatments for COPD, like bronchodilators and corticosteroids, focus on easing symptoms and reducing inflammation. However, THS (Tobacco Heating System) is unique because it offers a potential alternative to traditional smoking by heating tobacco instead of burning it. This method significantly reduces the harmful chemicals typically produced by cigarette smoke, which researchers believe could lessen the respiratory damage seen in COPD patients. Researchers are excited about this approach because it might provide a less harmful way for smokers with COPD to receive nicotine, potentially improving their lung function and overall health outcomes.
What evidence suggests that THS might be an effective treatment for COPD?
Research has shown that THS, a tobacco heating system, might help reduce COPD (Chronic Obstructive Pulmonary Disease) symptoms compared to smoking cigarettes. In this trial, participants will join either the THS arm or the Cigarette arm to compare effects. Studies have found that people who switch to products like THS experience fewer COPD flare-ups, which are times when symptoms worsen. A review of several studies found that using treatments like THS lowers the risk of these flare-ups compared to not using them. This can lead to better lung function and overall breathing health. While there is no cure for COPD, THS might be a promising alternative to smoking by potentially improving symptoms like cough and shortness of breath.678910
Who Is on the Research Team?
Xavier Jaumont, MD
Principal Investigator
Philip Morris Products S.A.
Are You a Good Fit for This Trial?
This trial is for individuals with COPD and chronic bronchitis who currently smoke or chew tobacco. The study aims to see if switching from regular cigarettes to a Tobacco Heating System (THS) can improve their respiratory symptoms and lung function.Inclusion Criteria
Exclusion Criteria
Timeline for a Trial Participant
Screening
Participants are screened for eligibility to participate in the trial
Treatment
Participants switch from combustible cigarettes to Tobacco Heating System (THS) or continue smoking cigarettes for 24 weeks
Follow-up
Participants are monitored for safety and effectiveness after treatment
What Are the Treatments Tested in This Trial?
Interventions
- THS
Find a Clinic Near You
Who Is Running the Clinical Trial?
Philip Morris Products S.A.
Lead Sponsor