Your session is about to expire
What is Osphena
OspemifeneThe Generic name of this drug
Treatment SummaryOspemifene is a drug used to treat pain during intercourse caused by menopause. It is a hormone-free medication that was approved by the FDA in 2013.
Osphenais the brand name
Osphena Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Osphena
Ospemifene
2013
3
Effectiveness
How Osphena Affects PatientsOspemifene is used to treat osteoporosis and may help to prevent breast cancer. It works by reducing the activity of the estrogen receptor (ER) alpha and beta, which are found in the body. Studies have shown that taking ospemifene in higher doses can reduce the risk of tumors. It also interacts with cells that build and break down bone, which helps reduce bone turnover.
How Osphena works in the bodyOspemifene is a drug that works specifically on estrogen receptors. It either boosts or blocks estrogen's activity in different parts of the body. When used in the uterus, it stimulates the tissue.
When to interrupt dosage
The proposed dosage of Osphena is contingent upon the established condition, including Menopause, extreme Dyspareunia and moderate Dyspareunia. The measure also changes according to the technique of delivery featured in the table below.Condition
Dosage
Administration
moderate Dyspareunia
60.0 mg,
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet - Oral, Tablet
moderate Vaginal dryness
60.0 mg,
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet - Oral, Tablet
Hot flashes
60.0 mg,
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet - Oral, Tablet
severe Dyspareunia
60.0 mg,
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet - Oral, Tablet
severe Vaginal dryness
60.0 mg,
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet - Oral, Tablet
Warnings
Osphena ContraindicationsCondition
Risk Level
Notes
estrogen-dependent neoplasia
Do Not Combine
history of deep venous thrombosis
Do Not Combine
undiagnosed abnormal genital bleeding
Do Not Combine
Severe Hypersensitivity Reactions
Do Not Combine
Ospemifene may interact with Pulse Frequency
Pulmonary Embolism
Do Not Combine
Deep Vein Thrombosis
Do Not Combine
Thromboembolism
Do Not Combine
Pulmonary Embolism
Do Not Combine
Common Osphena Drug Interactions
Drug Name
Risk Level
Description
Amoxapine
Major
The metabolism of Amoxapine can be decreased when combined with Ospemifene.
Astemizole
Major
The metabolism of Astemizole can be decreased when combined with Ospemifene.
Clomipramine
Major
The metabolism of Clomipramine can be decreased when combined with Ospemifene.
Clonidine
Major
The metabolism of Clonidine can be decreased when combined with Ospemifene.
Cyclophosphamide
Major
The metabolism of Cyclophosphamide can be decreased when combined with Ospemifene.
Osphena Toxicity & Overdose RiskCommon side effects (occurring in more than 1% of people) of taking this drug include increased body temperature, vaginal discharge, muscle cramps, genital discharge, and excessive sweating.
Osphena Novel Uses: Which Conditions Have a Clinical Trial Featuring Osphena?
16 active clinical trials are evaluating the potential of Osphena to ameliorate Menopause, severe and moderate Dyspareunia.Condition
Clinical Trials
Trial Phases
moderate Vaginal dryness
0 Actively Recruiting
Hot flashes
22 Actively Recruiting
Phase 2, Not Applicable, Phase 1, Phase 4, Early Phase 1
severe Vaginal dryness
0 Actively Recruiting
moderate Dyspareunia
0 Actively Recruiting
severe Dyspareunia
0 Actively Recruiting
Osphena Reviews: What are patients saying about Osphena?
5Patient Review
2/6/2019 This drug was a game-changer for me! It completely got rid of painful intercourse and vaginal dryness within two weeks. I found other vaginal treatments to be ineffective and messy in comparison. Osphena is easy to use, discreet, and covered by my insurance with no co-pay. I would recommend it to any woman dealing with these issues.
5Patient Review
1/29/2019 I've been on this medication for almost two years now. I started having really bad leg, arm, and neck cramps, so my doctor told me to take it a few days per week. That seemed to help. Then I had terrible watery discharge that seemed worse at night. It's also helped with pain during intercourse.
5Patient Review
9/3/2021 Osphena has completely changed my life for the better. Menopause had really taken a toll on me and it was impacting my marriage due to pain and dryness during sex. This medication has been a godsend, allowing me to be happy despite menopause.
5Patient Review
7/25/20185Patient Review
8/17/2018 Though excellent, the price unfortunately kept me from being able to continue using this drug.
5Patient Review
4/9/2019 Ospene has been a godsend for my stress incontinence. I had surgery to address the problem when I was younger, but it returned after menopause. This medication has allowed me to exercise and live my life without worry of wetting myself.
4.7Patient Review
4/30/2019 There was a significant improvement after starting this treatment. I can now have sex without pain! It also started working very quickly, within a month. The only downside is that I sometimes experience hot flashes which are quite uncomfortable.
4.3Patient Review
10/1/2021 This drug was effective in treating my painful intercourse and vaginal dryness. It also helped with my frequent UTIs. However, I found that if I missed a day or two, my moods would become very depressed. Has anyone else experienced this? Great as long as I take it but I'm worried about what might happen if I can't get or afford this med anymore.
3.7Patient Review
9/23/2019 Though this was effective in treating my symptoms, I experienced some very uncomfortable side effects. Namely, the weight gain and hot flashes/night sweats were unbearable. I stopped taking it and will have to look for another option.
3.3Patient Review
7/15/2021 Testosterone is much more effective than Osphena, and it doesn't cause weight gain. Testosterone has lots of benefits while Osphena really only addresses vaginal dryness. I'm glad my gynecologist is up-to-date on the latest research.
2.7Patient Review
2/8/2020 I'm very disappointed with this medication. I've only been taking it for a week and have gained three pounds, despite no change in my diet or exercise habits. It also cost me $100. I haven't been taking it long enough to see if it's effective for my vaginal issues, but I don't want to risk gaining more weight.
2.3Patient Review
12/17/2018 Osphena has not only helped with painful intercourse, but I have found that my sex drive has increased as well. I actually want to have sex now, which is something that I haven't felt in years. The side effects are manageable, and overall I would say that this drug is worth it.
2.3Patient Review
3/8/2019 I tried Osphena after other options failed me. The vaginal dryness was so bad that it caused tearing and made intercourse unbearable. Life was really tough, but things got better after using Osphena for a month. I've been on it for almost 3 years now and I'm really thankful that my doctor found something that worked for me.
1.7Patient Review
4/28/2019 I have the BRCA 1 gene. I had a total hysterectomy and my doctor recommended this drug. It worked like it was supposed to, but I was also taking CBD oil for hot flashes. Since starting this treatment, I've been having more hot flashes, anxiety, headaches, and depression. I'm seeing my doctor again on May 1st to discuss these concerns.
1.3Patient Review
8/17/2019 I gave this medication a month, and saw no results for my vaginal dryness. In fact, I developed other issues like a yeast infection and diarrhea. I don't think the benefits outweigh the risks here, so I'll be stopping this treatment.
Patient Q&A Section about osphena
These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.Is Osphena a hormone replacement?
"Osphena is not a form of estrogen. It is an alternative hormone-free option for women who do not want to take estrogen or use estrogen-based products."
Answered by AI
Is Osphena a hormone?
"Osphena works by replenishing lacked vaginal moisture, which can result in painful intercourse. The active ingredient in Osphena, ospemifene, is a selective estrogen receptor modulator (SERM).
Osphena is a non-hormonal treatment option for women who do not want to take estrogen or use estrogen-based products. Osphena replenishes vaginal moisture, which can result in painful intercourse. The active ingredient in Osphena, ospemifene, is a selective estrogen receptor modulator (SERM)."
Answered by AI
What are side effects of Osphena?
"The following are symptoms of blood clots: leg pain or swelling, skin that's warm to the touch, trouble breathing. The following are symptoms of a stroke: sudden weakness on one side of your body, headache, changes in your speech or vision, confusion. The following are symptoms of a heart attack: chest pain, shortness of breath, arm pain, cold sweat."
Answered by AI
Is Osphena safer than estrogen?
"The risks of stroke and deep vein thrombosis (DVT) are increased with estrogen-alone therapy. Cerebral thromboembolic and hemorrhagic stroke incidence rates were 1.13 and 3.39 per thousand women years, respectively, with OSPHENA 60 mg, vs. 3.15 and 0 per thousand women years, respectively, with placebo."
Answered by AI