Osphena

severe Vaginal dryness, Dyspareunia, severe Dyspareunia + 2 more
Treatment
20 Active Studies for Osphena

What is Osphena

OspemifeneThe Generic name of this drug
Treatment SummaryOspemifene is a drug used to treat pain during intercourse caused by menopause. It is a hormone-free medication that was approved by the FDA in 2013.
Osphenais the brand name
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Osphena Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Osphena
Ospemifene
2013
3

Effectiveness

How Osphena Affects PatientsOspemifene is used to treat osteoporosis and may help to prevent breast cancer. It works by reducing the activity of the estrogen receptor (ER) alpha and beta, which are found in the body. Studies have shown that taking ospemifene in higher doses can reduce the risk of tumors. It also interacts with cells that build and break down bone, which helps reduce bone turnover.
How Osphena works in the bodyOspemifene is a drug that works specifically on estrogen receptors. It either boosts or blocks estrogen's activity in different parts of the body. When used in the uterus, it stimulates the tissue.

When to interrupt dosage

The proposed dosage of Osphena is contingent upon the established condition, including Menopause, extreme Dyspareunia and moderate Dyspareunia. The measure also changes according to the technique of delivery featured in the table below.
Condition
Dosage
Administration
severe Vaginal dryness
60.0 mg,
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet - Oral, Tablet
Dyspareunia
60.0 mg,
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet - Oral, Tablet
severe Dyspareunia
60.0 mg,
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet - Oral, Tablet
moderate Vaginal dryness
60.0 mg,
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet - Oral, Tablet
Hot flashes
60.0 mg,
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet - Oral, Tablet

Warnings

Osphena Contraindications
Condition
Risk Level
Notes
estrogen-dependent neoplasia
Do Not Combine
Venous Thrombosis
Do Not Combine
undiagnosed abnormal genital bleeding
Do Not Combine
Pulmonary Embolism
Do Not Combine
Deep Vein Thrombosis
Do Not Combine
Thromboembolism
Do Not Combine
Pulmonary Embolism
Do Not Combine
Severe Hypersensitivity Reactions
Do Not Combine
Ospemifene may interact with Pulse Frequency
There are 20 known major drug interactions with Osphena.
Common Osphena Drug Interactions
Drug Name
Risk Level
Description
Amoxapine
Major
The metabolism of Amoxapine can be decreased when combined with Ospemifene.
Astemizole
Major
The metabolism of Astemizole can be decreased when combined with Ospemifene.
Clomipramine
Major
The metabolism of Clomipramine can be decreased when combined with Ospemifene.
Clonidine
Major
The metabolism of Clonidine can be decreased when combined with Ospemifene.
Cyclophosphamide
Major
The metabolism of Cyclophosphamide can be decreased when combined with Ospemifene.
Osphena Toxicity & Overdose RiskCommon side effects (occurring in more than 1% of people) of taking this drug include increased body temperature, vaginal discharge, muscle cramps, genital discharge, and excessive sweating.
image of a doctor in a lab doing drug, clinical research

Osphena Novel Uses: Which Conditions Have a Clinical Trial Featuring Osphena?

16 active clinical trials are evaluating the potential of Osphena to ameliorate Menopause, severe and moderate Dyspareunia.
Condition
Clinical Trials
Trial Phases
severe Vaginal dryness
0 Actively Recruiting
Dyspareunia
4 Actively Recruiting
Not Applicable
moderate Vaginal dryness
0 Actively Recruiting
severe Dyspareunia
0 Actively Recruiting
Hot flashes
16 Actively Recruiting
Phase 1, Phase 4, Not Applicable, Early Phase 1, Phase 2

Osphena Reviews: What are patients saying about Osphena?

5Patient Review
2/6/2019
Osphena for Painful Sexual Intercourse due to Menopause
This drug was a game-changer for me! It completely got rid of painful intercourse and vaginal dryness within two weeks. I found other vaginal treatments to be ineffective and messy in comparison. Osphena is easy to use, discreet, and covered by my insurance with no co-pay. I would recommend it to any woman dealing with these issues.
5Patient Review
1/29/2019
Osphena for Painful Sexual Intercourse due to Menopause
I've been on this medication for almost two years now. I started having really bad leg, arm, and neck cramps, so my doctor told me to take it a few days per week. That seemed to help. Then I had terrible watery discharge that seemed worse at night. It's also helped with pain during intercourse.
5Patient Review
9/3/2021
Osphena for Painful Sexual Intercourse due to Menopause
Osphena has completely changed my life for the better. Menopause had really taken a toll on me and it was impacting my marriage due to pain and dryness during sex. This medication has been a godsend, allowing me to be happy despite menopause.
5Patient Review
7/25/2018
Osphena for Painful Sexual Intercourse due to Menopause
5Patient Review
8/17/2018
Osphena for Painful Sexual Intercourse due to Menopause
Though excellent, the price unfortunately kept me from being able to continue using this drug.
View All Reviews
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Patient Q&A Section about osphena

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Is Osphena a hormone replacement?

"Osphena is not a form of estrogen. It is an alternative hormone-free option for women who do not want to take estrogen or use estrogen-based products."

Answered by AI

Is Osphena a hormone?

"Osphena works by replenishing lacked vaginal moisture, which can result in painful intercourse. The active ingredient in Osphena, ospemifene, is a selective estrogen receptor modulator (SERM).

Osphena is a non-hormonal treatment option for women who do not want to take estrogen or use estrogen-based products. Osphena replenishes vaginal moisture, which can result in painful intercourse. The active ingredient in Osphena, ospemifene, is a selective estrogen receptor modulator (SERM)."

Answered by AI

What are side effects of Osphena?

"The following are symptoms of blood clots: leg pain or swelling, skin that's warm to the touch, trouble breathing. The following are symptoms of a stroke: sudden weakness on one side of your body, headache, changes in your speech or vision, confusion. The following are symptoms of a heart attack: chest pain, shortness of breath, arm pain, cold sweat."

Answered by AI

Is Osphena safer than estrogen?

"The risks of stroke and deep vein thrombosis (DVT) are increased with estrogen-alone therapy. Cerebral thromboembolic and hemorrhagic stroke incidence rates were 1.13 and 3.39 per thousand women years, respectively, with OSPHENA 60 mg, vs. 3.15 and 0 per thousand women years, respectively, with placebo."

Answered by AI

Clinical Trials for Osphena

Have you considered Osphena clinical trials? We made a collection of clinical trials featuring Osphena, we think they might fit your search criteria.
Have you considered Osphena clinical trials? We made a collection of clinical trials featuring Osphena, we think they might fit your search criteria.
Have you considered Osphena clinical trials? We made a collection of clinical trials featuring Osphena, we think they might fit your search criteria.
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