Paragard T 380A

IUD therapy, dietary supplementation, Emergency Contraception + 3 more

Treatment

2 FDA approvals

3 Active Studies for Paragard T 380A

What is Paragard T 380A

Copper

The Generic name of this drug

Treatment Summary

Copper is a mineral found in small amounts in the body. It helps certain enzymes work properly, such as cytochrome c oxidase, monoamine oxidase, and superoxide dismutase. Copper is also used in some birth control devices, such as intrauterine devices.

O-Cal FA multivitamin

is the brand name

image of different drug pills on a surface

Paragard T 380A Overview & Background

Brand Name

Generic Name

First FDA Approval

How many FDA approvals?

O-Cal FA multivitamin

Copper

1970

4

Approved as Treatment by the FDA

Copper, otherwise known as O-Cal FA multivitamin, is approved by the FDA for 2 uses like IUD therapy and dietary supplementation .

IUD therapy

dietary supplementation

Effectiveness

How Paragard T 380A Affects Patients

Copper is an important part of many enzymes in the body. However, too much copper can have a negative effect on fertility, especially when it is released from copper-containing IUDs.

How Paragard T 380A works in the body

Copper is an important mineral that helps many enzymes in the body work properly. It is absorbed in the gut, and then transported to the golgi apparatus of cells. While in the body, it binds to proteins like ceruloplasmin, albumin, and alpha-2-macroglobulin. Copper is also used as a cofactor in enzymes that help connective tissue develop. A lack of copper can lead to serious conditions like Occipital Horn Syndrome and Menke's Disease, both of which can cause neurological impairment and death. Copper can also reduce the viability and motility of sperm, which is how it works

When to interrupt dosage

The proposed measure of Paragard T 380A is contingent upon the acknowledged condition, including Emergency Contraception, alimentary supplementation and Parenteral Feedings. The dosage can be found in the table below, dependent upon the given delivery technique.

Condition

Dosage

Administration

IUD therapy

0.16 mg, , 313.4 mg, 0.4 mg, 2.0 mg, 5.0 mg, 3.0 mg, 0.5 mg, 1.0 mg, 0.232 mg, 0.667 mg, 0.33 mg, 0.25 mg, 0.67 mg, 10.0 mg, 0.34 mg, 1.1 mg, 1.5 mg, 0.66 mg, 1.05 mg, 1.25 mg, 0.333 mg, 311.0 mg, 0.75 mg, 1.4 mg, 0.042 mg, 2.5 mg, 0.003 mg/mg, 0.00002222 mg/mg, 0.00007 mg/mg, 0.000008 mg/mg, 0.00005 mg/mg, 0.0001 mg/mg, 0.00033 mg/mg, 0.05 mg/mL, 0.1 mg/mL

Capsule, gelatin coated - Oral, Capsule, gelatin coated, Oral, , Intrauterine device, Intrauterine device - Intrauterine, Intrauterine, Intravenous, Tablet - Oral, Capsule, Capsule - Oral, Tablet, Liquid - Intravenous, Liquid, Solution - Intravenous, Solution, Powder, Capsule, liquid filled - Oral, Capsule, liquid filled, Tablet, coated - Oral, Tablet, coated, Kit - Oral, Tablet, chewable - Oral, Tablet, chewable, Kit, Tablet, film coated - Oral, Tablet, film coated, Powder - Oral, Tablet, extended release, Tablet, extended release - Oral, Tablet, effervescent - Oral, Tablet, effervescent, Liquid - Oral, Film, Powder, for solution - Oral, Powder, for solution, Film - Topical, Topical

dietary supplementation

0.16 mg, , 313.4 mg, 0.4 mg, 2.0 mg, 5.0 mg, 3.0 mg, 0.5 mg, 1.0 mg, 0.232 mg, 0.667 mg, 0.33 mg, 0.25 mg, 0.67 mg, 10.0 mg, 0.34 mg, 1.1 mg, 1.5 mg, 0.66 mg, 1.05 mg, 1.25 mg, 0.333 mg, 311.0 mg, 0.75 mg, 1.4 mg, 0.042 mg, 2.5 mg, 0.003 mg/mg, 0.00002222 mg/mg, 0.00007 mg/mg, 0.000008 mg/mg, 0.00005 mg/mg, 0.0001 mg/mg, 0.00033 mg/mg, 0.05 mg/mL, 0.1 mg/mL

Capsule, gelatin coated - Oral, Capsule, gelatin coated, Oral, , Intrauterine device, Intrauterine device - Intrauterine, Intrauterine, Intravenous, Tablet - Oral, Capsule, Capsule - Oral, Tablet, Liquid - Intravenous, Liquid, Solution - Intravenous, Solution, Powder, Capsule, liquid filled - Oral, Capsule, liquid filled, Tablet, coated - Oral, Tablet, coated, Kit - Oral, Tablet, chewable - Oral, Tablet, chewable, Kit, Tablet, film coated - Oral, Tablet, film coated, Powder - Oral, Tablet, extended release, Tablet, extended release - Oral, Tablet, effervescent - Oral, Tablet, effervescent, Liquid - Oral, Film, Powder, for solution - Oral, Powder, for solution, Film - Topical, Topical

Emergency Contraception

0.16 mg, , 313.4 mg, 0.4 mg, 2.0 mg, 5.0 mg, 3.0 mg, 0.5 mg, 1.0 mg, 0.232 mg, 0.667 mg, 0.33 mg, 0.25 mg, 0.67 mg, 10.0 mg, 0.34 mg, 1.1 mg, 1.5 mg, 0.66 mg, 1.05 mg, 1.25 mg, 0.333 mg, 311.0 mg, 0.75 mg, 1.4 mg, 0.042 mg, 2.5 mg, 0.003 mg/mg, 0.00002222 mg/mg, 0.00007 mg/mg, 0.000008 mg/mg, 0.00005 mg/mg, 0.0001 mg/mg, 0.00033 mg/mg, 0.05 mg/mL, 0.1 mg/mL

Capsule, gelatin coated - Oral, Capsule, gelatin coated, Oral, , Intrauterine device, Intrauterine device - Intrauterine, Intrauterine, Intravenous, Tablet - Oral, Capsule, Capsule - Oral, Tablet, Liquid - Intravenous, Liquid, Solution - Intravenous, Solution, Powder, Capsule, liquid filled - Oral, Capsule, liquid filled, Tablet, coated - Oral, Tablet, coated, Kit - Oral, Tablet, chewable - Oral, Tablet, chewable, Kit, Tablet, film coated - Oral, Tablet, film coated, Powder - Oral, Tablet, extended release, Tablet, extended release - Oral, Tablet, effervescent - Oral, Tablet, effervescent, Liquid - Oral, Film, Powder, for solution - Oral, Powder, for solution, Film - Topical, Topical

Parenteral Feedings

0.16 mg, , 313.4 mg, 0.4 mg, 2.0 mg, 5.0 mg, 3.0 mg, 0.5 mg, 1.0 mg, 0.232 mg, 0.667 mg, 0.33 mg, 0.25 mg, 0.67 mg, 10.0 mg, 0.34 mg, 1.1 mg, 1.5 mg, 0.66 mg, 1.05 mg, 1.25 mg, 0.333 mg, 311.0 mg, 0.75 mg, 1.4 mg, 0.042 mg, 2.5 mg, 0.003 mg/mg, 0.00002222 mg/mg, 0.00007 mg/mg, 0.000008 mg/mg, 0.00005 mg/mg, 0.0001 mg/mg, 0.00033 mg/mg, 0.05 mg/mL, 0.1 mg/mL

Capsule, gelatin coated - Oral, Capsule, gelatin coated, Oral, , Intrauterine device, Intrauterine device - Intrauterine, Intrauterine, Intravenous, Tablet - Oral, Capsule, Capsule - Oral, Tablet, Liquid - Intravenous, Liquid, Solution - Intravenous, Solution, Powder, Capsule, liquid filled - Oral, Capsule, liquid filled, Tablet, coated - Oral, Tablet, coated, Kit - Oral, Tablet, chewable - Oral, Tablet, chewable, Kit, Tablet, film coated - Oral, Tablet, film coated, Powder - Oral, Tablet, extended release, Tablet, extended release - Oral, Tablet, effervescent - Oral, Tablet, effervescent, Liquid - Oral, Film, Powder, for solution - Oral, Powder, for solution, Film - Topical, Topical

Trace Element Deficiency

0.16 mg, , 313.4 mg, 0.4 mg, 2.0 mg, 5.0 mg, 3.0 mg, 0.5 mg, 1.0 mg, 0.232 mg, 0.667 mg, 0.33 mg, 0.25 mg, 0.67 mg, 10.0 mg, 0.34 mg, 1.1 mg, 1.5 mg, 0.66 mg, 1.05 mg, 1.25 mg, 0.333 mg, 311.0 mg, 0.75 mg, 1.4 mg, 0.042 mg, 2.5 mg, 0.003 mg/mg, 0.00002222 mg/mg, 0.00007 mg/mg, 0.000008 mg/mg, 0.00005 mg/mg, 0.0001 mg/mg, 0.00033 mg/mg, 0.05 mg/mL, 0.1 mg/mL

Capsule, gelatin coated - Oral, Capsule, gelatin coated, Oral, , Intrauterine device, Intrauterine device - Intrauterine, Intrauterine, Intravenous, Tablet - Oral, Capsule, Capsule - Oral, Tablet, Liquid - Intravenous, Liquid, Solution - Intravenous, Solution, Powder, Capsule, liquid filled - Oral, Capsule, liquid filled, Tablet, coated - Oral, Tablet, coated, Kit - Oral, Tablet, chewable - Oral, Tablet, chewable, Kit, Tablet, film coated - Oral, Tablet, film coated, Powder - Oral, Tablet, extended release, Tablet, extended release - Oral, Tablet, effervescent - Oral, Tablet, effervescent, Liquid - Oral, Film, Powder, for solution - Oral, Powder, for solution, Film - Topical, Topical

Obesity

0.16 mg, , 313.4 mg, 0.4 mg, 2.0 mg, 5.0 mg, 3.0 mg, 0.5 mg, 1.0 mg, 0.232 mg, 0.667 mg, 0.33 mg, 0.25 mg, 0.67 mg, 10.0 mg, 0.34 mg, 1.1 mg, 1.5 mg, 0.66 mg, 1.05 mg, 1.25 mg, 0.333 mg, 311.0 mg, 0.75 mg, 1.4 mg, 0.042 mg, 2.5 mg, 0.003 mg/mg, 0.00002222 mg/mg, 0.00007 mg/mg, 0.000008 mg/mg, 0.00005 mg/mg, 0.0001 mg/mg, 0.00033 mg/mg, 0.05 mg/mL, 0.1 mg/mL

Capsule, gelatin coated - Oral, Capsule, gelatin coated, Oral, , Intrauterine device, Intrauterine device - Intrauterine, Intrauterine, Intravenous, Tablet - Oral, Capsule, Capsule - Oral, Tablet, Liquid - Intravenous, Liquid, Solution - Intravenous, Solution, Powder, Capsule, liquid filled - Oral, Capsule, liquid filled, Tablet, coated - Oral, Tablet, coated, Kit - Oral, Tablet, chewable - Oral, Tablet, chewable, Kit, Tablet, film coated - Oral, Tablet, film coated, Powder - Oral, Tablet, extended release, Tablet, extended release - Oral, Tablet, effervescent - Oral, Tablet, effervescent, Liquid - Oral, Film, Powder, for solution - Oral, Powder, for solution, Film - Topical, Topical

Warnings

There are 2 known major drug interactions with Paragard T 380A.

Common Paragard T 380A Drug Interactions

Drug Name

Risk Level

Description

Dehydroascorbic acid

Moderate

The serum concentration of Dehydroascorbic acid can be decreased when it is combined with Copper.

Zinc ascorbate

Moderate

The serum concentration of Zinc ascorbate can be decreased when it is combined with Copper.

Paragard T 380A Toxicity & Overdose Risk

Copper toxicity is thought to be caused by chemical reactions with high copper concentrations that create harmful oxygen molecules.

image of a doctor in a lab doing drug, clinical research

Paragard T 380A Novel Uses: Which Conditions Have a Clinical Trial Featuring Paragard T 380A?

Two active trials are assessing the potential of Paragard T 380A to provide IUD therapy, dietary supplementation and Parenteral Feedings for various conditions.

Condition

Clinical Trials

Trial Phases

Obesity

0 Actively Recruiting

IUD therapy

2 Actively Recruiting

Not Applicable

Parenteral Feedings

0 Actively Recruiting

dietary supplementation

0 Actively Recruiting

Trace Element Deficiency

0 Actively Recruiting

Emergency Contraception

1 Actively Recruiting

Phase 4

Paragard T 380A Reviews: What are patients saying about Paragard T 380A?

5

Patient Review

5/27/2022

Paragard T 380A for Birth Control

I just received Paraguard this morning and my review is for insertion. It was not as bad as I have read. A mild to moderate cramp and it was over. On scale of 1-10 I’d say a 2/3. It was not bad at all. I would note that I took 3 aleve 1 hr before appointment and was on my period. I have 1 child age 22. I will give another review as time goes on how I like it. But so far so good, only mild cramping since this morning..

5

Patient Review

9/23/2022

Paragard T 380A for Birth Control

I was looking for a non-hormonal option for birth control and found this. The insertion process was painful, but it was worth it. I haven't had any issues with side effects like crazy bleeding or weight gain, and my acne has cleared up.

4.7

Patient Review

8/3/2022

Paragard T 380A for Birth Control

I had the copper IUD for almost 2 years and it was my favorite! The only reason why i got off of it was because I was an athlete in college at the time and couldn't afford to deal with the heavy cramping and bleeding but I think now that I have a more sedentary lifestyle, I'd go back!I will note that for my periods I use "regular" tampons on my heavy days but on the paragard, I used the super ultra heavy tampons or whatever for like 8 days lol

2

Patient Review

8/17/2022

Paragard T 380A for Birth Control

The only benefit I experienced was that I did not get pregnant. However, the insertion process was extremely painful. The periods I experienced were also horrible and very painful. In addition, I bled so much that I became iron deficient and dizzy. Intercourse was also quite painful. Overall, I would NOT recommend this product to anyone.

1.3

Patient Review

7/14/2022

Paragard T 380A for Birth Control

My experience with a copper IUD was really terrible. It caused me all sorts of problems like daily pain, brain fog, and severe food sensitivities. My body eventually expelled it, but not completely so I had to have surgery to get the rest of it out.

1

Patient Review

6/15/2022

Paragard T 380A for Birth Control

The pain three days after insertion was unbearable. It was worse than childbirth contractions. I had to get it removed on May 11th and since then, I've been constantly bleeding. It's very draining both physically and emotionally. Do not get this form of birth control!

1

Patient Review

7/28/2022

Paragard T 380A for Birth Control

I had a really negative experience with the Copper IUD. The cramping after it was fitted was terrible, and I've been dealing with non-stop flooding for three weeks now. My surgery is removing it tomorrow, and I'm just hoping that things will go back to normal afterwards.
image of drug pills surrounding a glass of water symbolizing drug consumption

Patient Q&A Section about paragard t 380a

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

What are the side effects of ParaGard IUD?

"Anemia, expelling, pain during sex, spotting, prolonged periods, painful periods, vaginal irritation, and vaginal discharge are all symptoms that can result from having a low red blood cell count."

Answered by AI

What is ParaGard T 380A?

"The ParaGard device is a T-shaped plastic frame that is inserted into the uterus and can provide long-term birth control (contraception). It is a nonhormonal IUD option."

Answered by AI

What is 380A Copper T?

"It is also one of the cheapest IUDs .

The Pregna Copper T 380A / Copper t Intrauterine device is a safe and trustworthy birth control device that can be used for up to 10 years without having to worry about unwanted pregnancy. There are many advantages to using this device, including its reliability, safety, and easy of use, as well as its affordability."

Answered by AI

What is IUD 380A?

"1995 Sep;52(3):169-75

The TCu 380A IUD is a contraceptive method that can be reversed and is permanent for women over 35 years of age."

Answered by AI

Clinical Trials for Paragard T 380A

Image of Indiana University Hospital in Indianapolis, United States.

Carevix for IUD Therapy

18+
Female
Indianapolis, IN

The goal of this clinical trial is to evaluate patient-reported pain, bleeding, and device efficiency along with provider satisfaction and ease of use between IUD insertions using a suction cervical stabilizer (new device, FDA approved, atraumatic) and single-tooth tenaculum (standard, traumatic). Our aims are to: * assess and compare patient-reported pain during IUD insertion between the Carevix device and tenaculum. * assess predictors of pain scores including between nulliparous and multiparous patients * assess provider-reported ease of use and satisfaction Participants (including providers) will: * be randomized to receive one device to complete the IUD procedure * complete a survey following the procedure

Waitlist Available
Has No Placebo

Indiana University Hospital

Alissa M Conklin, MD

Aspivix SA

Image of Planned Parenthood Association of Utah in Salt Lake City, United States.

Etonogestrel Implant + Levonorgestrel for Emergency Contraception

18 - 35
Female
Salt Lake City, UT

Intrauterine devices (IUDs) are highly effective to prevent pregnancy when used for emergency contraception (following unprotected intercourse in the last 3 days), but data are lacking for people who desire an etonogestrel (ENG) contraceptive implant in this situation. This proposal will identify the most effective way to start an implant for emergency contraception using a randomized controlled trial comparing pregnancy risk between those receiving the implant vs. the implant plus oral emergency contraception (EC). Data from this project will inform clinical practice and add another option, the implant, for those desiring a long acting, highly effective contraceptive method when they present for emergency contraception.

Phase 4
Recruiting

Planned Parenthood Association of Utah

Lori Gawron, MD, MPH