Darvon

Chronic Pain
Treatment
2 FDA approvals
20 Active Studies for Darvon

What is Darvon

DextropropoxypheneThe Generic name of this drug
Treatment SummaryDextropropoxyphene is an opioid pain reliever that was manufactured by Eli Lilly and Company. It had been used to treat mild pain, but it was eventually removed from the market due to the risk of cardiac arrhythmias and overdose. Dextropropoxyphene is the only form of propoxyphene that has any pain-relieving effects, whereas the levo-isomer only has a limited effect on coughs.
Propoxypheneis the brand name
image of different drug pills on a surface
Darvon Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Propoxyphene
Dextropropoxyphene
1973
64

Approved as Treatment by the FDA

Dextropropoxyphene, also known as Propoxyphene, is approved by the FDA for 2 uses like Chronic Pain and Pain .
Chronic Pain
Helps manage Pain
Pain
Helps manage Pain

Effectiveness

How Darvon Affects PatientsPropoxyphene is a synthetic drug similar to methadone. It works by attaching to the same receptors in the brain as opiates, which makes a person feel less pain. Propoxyphene does not help reduce coughing or fever.
How Darvon works in the bodyPropoxyphene works by interacting with special receptors in the brain and central nervous system. These receptors, called OP1, OP2, and OP3, help regulate pain signals in the body. Propoxyphene primarily affects OP3 receptors, which help decrease the activity of certain nerve cells, preventing them from sending pain signals. This helps to reduce pain and discomfort. Propoxyphene also affects other receptors which help to reduce the release of certain neurotransmitters, including substances that are involved in inflammation and stress. Finally, Propoxyphene helps reduce neuronal excitability by closing certain voltage-operated calcium channels and opening others,

When to interrupt dosage

The advocated dose of Darvon is contingent upon the diagnosed condition. The magnitude of dosage is also dependent on the technique of administration outlined in the table below.
Condition
Dosage
Administration
Chronic Pain
, 65.0 mg, 100.0 mg, 50.0 mg
, Oral, Tablet, film coated, Tablet, film coated - Oral, Capsule, Capsule - Oral, Tablet, Tablet - Oral

Warnings

Darvon has five contraindications, so it should not be ingested while struggling with any of the conditions enumerated in the subsequent table.Darvon Contraindications
Condition
Risk Level
Notes
Hypercarbia
Do Not Combine
Asthma
Do Not Combine
Mental Depression
Do Not Combine
Intestinal Pseudo-Obstruction
Do Not Combine
Asthma
Do Not Combine
There are 20 known major drug interactions with Darvon.
Common Darvon Drug Interactions
Drug Name
Risk Level
Description
7,8-Dichloro-1,2,3,4-tetrahydroisoquinoline
Major
The risk or severity of adverse effects can be increased when Dextropropoxyphene is combined with 7,8-Dichloro-1,2,3,4-tetrahydroisoquinoline.
Abemaciclib
Major
The metabolism of Abemaciclib can be decreased when combined with Dextropropoxyphene.
Acalabrutinib
Major
The metabolism of Acalabrutinib can be decreased when combined with Dextropropoxyphene.
Alectinib
Major
The metabolism of Alectinib can be decreased when combined with Dextropropoxyphene.
Alpelisib
Major
The metabolism of Alpelisib can be decreased when combined with Dextropropoxyphene.
Darvon Toxicity & Overdose RiskSymptoms of propoxyphene overdose include falling into a coma, slowed breathing, low blood pressure, and a buildup of fluid in the lungs. Seizures are also more common in patients who have overdosed on propoxyphene than on other opioids. The lowest toxic dose of propoxyphene in rats has been found to be 230mg/kg when taken orally.
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Darvon Novel Uses: Which Conditions Have a Clinical Trial Featuring Darvon?

A total of 172 active trials are currently being conducted to assess the potential of Darvon in managing Chronic Pain.
Condition
Clinical Trials
Trial Phases
Chronic Pain
129 Actively Recruiting
Not Applicable, Phase 4, Phase 2, Phase 3, Early Phase 1, Phase 1

Darvon Reviews: What are patients saying about Darvon?

5Patient Review
11/23/2010
Darvon for Pain
This treatment really helps with my lower back pain. It's the only thing that has been effective for my headaches as well.
5Patient Review
2/22/2014
Darvon for Pain
This treatment is effective.
5Patient Review
10/12/2010
Darvon for Pain
Unfortunately, this medication did not do much for me. I have a lot of back problems and this didn't help alleviate any pain.
4.7Patient Review
9/1/2009
Darvon for Pain
Darvon 65 capsules unfortunately did nothing to relieve the pain I experience in my lower back.
4.3Patient Review
11/5/2011
Darvon for Pain
This drug is great. It really helped me.
3.7Patient Review
6/6/2010
Darvon for Pain
The primary effect I experienced while taking this medication was intense hallucinations. It provided very little pain relief, which is why I was prescribed it in the first place. I quickly returned it to my surgeon and got a replacement within the week.
3Patient Review
4/6/2010
Darvon for Pain
I took this medication for knee and hip pain, but it barely did anything. I accidentally took two pills, and there was still no significant change. The only side effects I felt were flushness and slight dizziness.
3Patient Review
2/1/2011
Darvon for Osteoporosis
Unfortunately, this medication severely impairs my vision to the point where I can't read. Additionally, it gives me excruciating abdominal pain that feels like cramps but much worse.
3Patient Review
2/3/2011
Darvon for Osteoporosis
This drug is effective. I'm grateful for modern medicine.
3Patient Review
2/3/2011
Darvon for Osteoporosis
This drug is great. It really helped me.
3Patient Review
2/4/2011
Darvon for Osteoporosis
This drug is effective. I'm grateful for modern medicine.
3Patient Review
2/4/2011
Darvon for Osteoporosis
This drug is great. I'm grateful for modern medicine.
3Patient Review
9/8/2010
Darvon for Pain
I'm not comfortable recommending this drug to anyone after my cousin died from an overdose.
1.7Patient Review
6/17/2009
Darvon for Pain
1.3Patient Review
12/24/2009
Darvon for Pain
I use this to manage my chronic pain from spinal issues, fibromyalgia, and it works better for me than Oxycontin did.
1Patient Review
7/5/2010
Darvon for Pain
Roxicodone 30 mg blue tablets have been the most effective treatment for my back problems. I would highly recommend them to anyone with similar issues.
1Patient Review
11/26/2010
Darvon for Pain
I've been taking Darvon for migraines for over 50 years. It's not a cure-all, but it does help significantly reduce the pain most of the time. I take oxycodone when the pain is really bad, but that comes with its own set of problems. People need to be more careful and understand how their bodies react to drugs before taking them.
image of drug pills surrounding a glass of water symbolizing drug consumption

Patient Q&A Section about darvon

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Is Darvon still prescribed?

"As of today, propoxyphene-containing products are no longer available in America after the FDA concluded that the risks associated with propoxyphene outweigh the benefits."

Answered by AI

What is the generic name for Darvon?

"Darvon is a drug that is used to treat mild to moderate pain. It is classified as a narcotic, which is a type of drug that is derived from the opium poppy."

Answered by AI

What is difference between Darvon and Darvocet?

"The FDA has ordered Xanodyne to conduct a safety study which has prompted the agency's decision to remove Darvon from the market. This is due to Darvon only containing propoxyphene as an active ingredient, whereas Darvocet combines it with acetaminophen."

Answered by AI

Why was Darvon taken off the market?

"The FDA withdrew Darvon and Darvocet from the market after a study found that the drugs put patients at risk of arrhythmias, or heart rhythm abnormalities. The FDA decided that the risks of the drugs were greater than their benefits to patients suffering from mild to moderate pain."

Answered by AI

Clinical Trials for Darvon

Image of Vanderbilt University Medical Center in Nashville, United States.

Lidocaine Infusions for Postoperative Pain

18+
All Sexes
Nashville, TN
The goal of this single-center, pragmatic, randomized, blinded, placebo-controlled trial is to evaluate the impact of intravenous (IV) lidocaine within the existing Enhanced Recovery After Surgery (ERAS)program on outcomes in patients after major abdominal surgery. The main questions the trial aims to answer are: The primary hypothesis is that utilization of IV lidocaine as part of a perioperative multimodal pain regimen will result in a reduction in hospital Case Mix Index-Adjusted Resource Length of Stay (CARLOS). The secondary hypotheses are that lidocaine infusion will result in a reduction in total inpatient opioid consumption (oral morphine milligram equivalents, oMMEs) and pain scores, and improved surgical outcomes (including return of bowel function, ileus, nausea, rapid responses called, surgical site infections, and ICU transfers), while also having minimal incidence of side effects (including double/blurry vision, tinnitus, sedation, and adverse events requiring early cessation).
Phase 4
Waitlist Available
Vanderbilt University Medical CenterDanial Shams, MD
Image of Baylor College of Medicine/Texas Children's Hospital in Austin, United States.

Guided Imagery Therapy for Abdominal Pain

7 - 12
All Sexes
Austin, TX
Chronic abdominal pain is common among children, and the majority of cases are attributed to functional abdominal pain disorders. One approach to treating these disorders is by using psychological therapies. This clinical trial aims to see how well pre-recorded guided imagery therapy sessions help children's abdominal pain when delivered via a mobile application (app) on a smartphone or tablet. Participants will complete a baseline abdominal pain and stooling diary to determine eligibility, as well as other surveys. Eligible participants will be given access to the guided imagery therapy mobile application. This intervention asks participants to listen to a 10- to 15-minute GIT session 5 out of 7 days per week for 8 weeks, in addition to their usual care for their abdominal pain. Then, participants will complete another abdominal pain and stooling diary, along with other psychometric surveys, at the end of this intervention period. Participants will also collect another diary and surveys 3 months post-treatment.
Waitlist Available
Has No Placebo
Baylor College of Medicine/Texas Children's Hospital (+1 Sites)
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Erector Spinae Plane Block for Pain

21 - 75
All Sexes
Cleveland, OH
As per usual care for spine surgery, participants will have their back cleaned with alcohol and a needle will be placed using ultrasound for the ESP block. Through the needle, a small catheter will be placed in the participants back and the needle removed. Approximately one hour prior to the start of surgery, a numbing medication (ropivacaine, similar to Novocaine) in combination with dexmedetomidine (a pain medicine that is used in nerve block and that is not a narcotic) and contrast dye (iohexol) will be injected through the catheter. Participants will then go through the QST procedure (test of buzzing sensation and temperature sensation through pads applied to their skin) to assess the numb areas and then head to the operating room. In the operating room, the catheter will be removed after the surgeon obtains baseline CT scan images of the spine. Once surgery is completed, investigators will record pain scores over the next four days in the hospital and the amount of pain medication needed for controlling pain related to the surgery.
Recruiting
Has No Placebo
University Hospitals Cleveland Medical CenterSalim Hayek, MD
Have you considered Darvon clinical trials? We made a collection of clinical trials featuring Darvon, we think they might fit your search criteria.Go to Trials
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Digital Media for Anxiety in Children

5 - 23
All Sexes
Vancouver, Canada
The goal of this clinical trial is to learn whether different forms of media (2D, 360, or 360 in virtual reality) have different impacts on pre-procedural anxiety and post-procedural pain in children. The main questions it aims to answer are: Does one type (and richness) of media reduce pre-procedural anxiety and post-procedural pain more than another type of media? For example, will learning about an upcoming procedure by watching a 360 video in virtual reality reduce pre-procedural anxiety more than learning about the same upcoming procedure by watching it in a 2D video or 360 video? The second question is whether watching a 360 video in VR about an upcoming procedure more effective in reducing pre-procedural anxiety and post-procedural pain compared to the 2D video or the 360 video without VR groups for specific procedures? For example, is watching an explanation of a procedure in VR always more effective in reducing pre-procedural anxiety and post-procedural pain, or is it procedure specific (i.e., watching a video about surgery preparation is more effective in VR, but for cast removal it doesn't matter whether participants learn about their procedure viewed through VR, 360 video, or 2D)?
Recruiting
Has No Placebo
BC Children's Hospital
Image of Active Aging Research Team, Robert H. N. Ho Research Centre in Vancouver, Canada.

Choose to Move Replacement Ready for Osteoarthritis

18+
All Sexes
Vancouver, Canada
Choose to Move (CTM) is a 3-month, choice-based health-promoting program for low active older adults being scaled-up across British Columbia (BC), Canada. Recently, the investigators adapted CTM for the \>14000 people in BC who are on surgical waitlists for total knee replacement or total hip replacement (TKR/THR) for osteoarthritis (OA). The primary goal of this observational study is to learn if the adapted program, Choose to Move Replacement Ready (CTM-RR), is feasible to deliver to people with hip and/or knee osteoarthritis who are on surgical waitlists for TKR/THR. Participants who enrol in CTM-RR will answer online survey questions about the program and about their physical activity, mobility, pain, function, quality of life, willingness to undergo surgery, overall perception of their joint condition, psychosocial health, self-efficacy, social isolation, loneliness, and sedentary time. CTM-RR activity coaches will also answer online survey questions about the program. CTM-RR participants, activity coaches, and referral partners will also participate in interviews about the program.
Recruiting
Has No Placebo
Active Aging Research Team, Robert H. N. Ho Research CentreHeather A. McKay, PhD
Image of Manitoba Men's Health Clinic in Winnipeg, Canada.

Virtual Reality for Pain and Anxiety

18+
Male
Winnipeg, Canada
The goal of this clinical trial is to learn if a virtual reality (VR) program (TRIPP) can reduce pain, anxiety, and distress in adult men (aged 18+) undergoing a vasectomy under local anesthesia. The main questions it aims to answer are: * Does using VR during a vasectomy lower patients' pain during the procedure compared to standard care? * Does VR reduce anxiety and distress compared to standard care? * Are patients more satisfied with their experience when using VR compared to standard care? Researchers will compare two groups: * VR group: Patients will use a VR headset with a guided meditation program (TRIPP) during their vasectomy. * Control group: Patients will receive standard care (no VR). Participants will: * Be randomly assigned to either the VR group or control group. * Complete brief questionnaires before, during, and after the procedure (about 15-20 minutes each time). * (VR group only) Use a VR headset during the procedure and provide optional feedback about the experience. Why is this important? Vasectomies are typically done with local anesthesia (pain relief), but many patients still feel anxiety or discomfort. VR may help distract and relax patients, improving their experience. This study will help health professionals understand if VR could be a useful option for future patients.
Waitlist Available
Has No Placebo
Manitoba Men's Health ClinicRenée El-Gabalawy, MA, PhD, C. Psych
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