Vantas
Puberty, Precocious, Prostatic Neoplasms
Treatment
1 Active Study for Vantas
Treatment for
Puberty, Precocious
What is Vantas
Histrelin
The Generic name of this drug
Treatment Summary
Histrelin is a long-acting medication used to reduce the body’s production of hormones that control fertility. When used in children, it can help delay or prevent early puberty. In adults, it can be used to treat advanced prostate cancer. Histrelin works by stimulating the pituitary gland to produce a temporary increase in hormones like testosterone and dihydrotestosterone. This is followed by a decrease in these hormones due to a decrease in the sensitivity of the pituitary gland to histrelin. Histrelin is available under the brand names Supprelin LA and Vantas.
Vantas
is the brand name
Vantas Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Vantas
Histrelin
2004
3
Effectiveness
How Vantas Affects Patients
Histrelin is a medicine used to suppress hormones in the body, which can help slow down puberty in children. It cannot be taken orally and is available as two different products, Vantas and Supprelin LA. Taking this medicine can cause a transient increase in certain hormones for the first week of treatment, such as estradiol in women and testosterone in both sexes. In order to monitor hormone levels, laboratory tests are recommended. It is important to note that using histrelin can lead to psychiatric events, convulsions, pseudotumor cerebri, spinal cord compression, urinary tract obstruction, an increased risk of
How Vantas works in the body
Histrelin is a hormone-blocking drug. When used as an implant, it is released in the body in continual doses. At first, it increases the hormones that control sexual maturity and reproduction (like testosterone). But over time, it desensitizes the receptors that detect these hormones, reducing the levels of these hormones in the body. In children, it lowers the hormones that stimulate puberty, allowing them to remain at a normal height. In adults with prostate cancer, it stops the production of testosterone, preventing the cancer cells from growing.
When to interrupt dosage
The amount of Vantas is contingent upon the acknowledged ailment. The measure of dosage corresponds to the technique of delivery (e.g. Implant; Kit or Implant; Kit - Subcutaneous) provided in the table beneath.
Condition
Dosage
Administration
Puberty, Precocious
50.0 mg,
, Implant, Subcutaneous, Implant - Subcutaneous, Implant; Kit, Implant; Kit - Subcutaneous
Prostatic Neoplasms
50.0 mg,
, Implant, Subcutaneous, Implant - Subcutaneous, Implant; Kit, Implant; Kit - Subcutaneous
Warnings
Vantas has one recognized contraindication, so it should not be taken for the conditions outlined in the following table.
Vantas Contraindications
Condition
Risk Level
Notes
Pulse Frequency
Do Not Combine
There are 20 known major drug interactions with Vantas.
Common Vantas Drug Interactions
Drug Name
Risk Level
Description
Capromab pendetide
Major
Histrelin may decrease effectiveness of Capromab pendetide as a diagnostic agent.
Corifollitropin alfa
Major
The therapeutic efficacy of Corifollitropin alfa can be increased when used in combination with Histrelin.
Hydroxyzine
Major
The risk or severity of QTc prolongation can be increased when Histrelin is combined with Hydroxyzine.
Mobocertinib
Major
The risk or severity of QTc prolongation can be increased when Histrelin is combined with Mobocertinib.
Ziprasidone
Major
The risk or severity of QTc prolongation can be increased when Histrelin is combined with Ziprasidone.
Vantas Toxicity & Overdose Risk
Studies on animals show no signs of serious toxicity when they were injected with up to 200 mcg/kg (rats and rabbits) or 2000 mcg/kg (mice) of histrelin acetate. This amount is much higher than the recommended maximum dose for humans of 10 mcg/kg/day. In clinical trials, no cases of overdose were reported. If an accidental or intentional overdose were to occur, it is unlikely due to the constant delivery of histrelin from the implants.
Vantas Novel Uses: Which Conditions Have a Clinical Trial Featuring Vantas?
4 active studies are investigating the potential of Vantas to combat Advanced Prostate Cancer.
Condition
Clinical Trials
Trial Phases
Prostatic Neoplasms
0 Actively Recruiting
Puberty, Precocious
1 Actively Recruiting
Phase 3
Vantas Reviews: What are patients saying about Vantas?
5
Patient Review
8/18/2011
Vantas for Advanced Form of Prostate Cancer
5
Patient Review
6/26/2009
Vantas for Advanced Form of Prostate Cancer
5
Patient Review
10/16/2008
Vantas for Advanced Form of Prostate Cancer
4.7
Patient Review
2/6/2010
Vantas for Advanced Form of Prostate Cancer
3.7
Patient Review
10/9/2011
Vantas for Advanced Form of Prostate Cancer
3.7
Patient Review
4/14/2012
Vantas for Advanced Form of Prostate Cancer
3.3
Patient Review
9/13/2013
Vantas for Advanced Form of Prostate Cancer
3
Patient Review
4/14/2012
Vantas for Puberty at an Earlier Age than would be expected
1.3
Patient Review
10/4/2011
Vantas for Advanced Form of Prostate Cancer
Patient Q&A Section about vantas
These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.
Is Vantas discontinued?
"· Endo International plc (NASDAQ: ENDP) (“Endo” or the “Company”), a global specialty pharmaceutical company focused on improving patients’ lives while creating shareholder value, today announced that it has discontinued the sale and marketing of Vantas in the United States
In September 2021, Endo will no longer sell or market Vantas in the United States."
Answered by AI
What is Vantas implant?
"The Vantas implant is a sterile, non-biodegradable drug delivery system that is designed to continuously deliver histrelin for 12 months after it is implanted subcutaneously. The Vantas implant contains 50 mg of histrelin acetate."
Answered by AI
How much is Vantas?
"Vantas was approved by the FDA in 2004 to treat late-stage prostate cancer. It has a list price of $4,400."
Answered by AI
What is Vantas for?
"Vantas contains histrelin acetate, which lowers the levels of male sex hormones like testosterone to help slow the growth of prostate cancer cells. Vantas comes as an implant that's inserted under the skin."
Answered by AI