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What is Zytiga
AbirateroneThe Generic name of this drug
Treatment SummaryAbiraterone is a type of steroid hormone used to treat prostate cancer that does not respond to other treatments. It is available as an acetate salt, which is more easily absorbed by the body and less likely to be broken down. Abiraterone was approved by the FDA in 2011.
Zytigais the brand name
Zytiga Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Zytiga
Abiraterone
2011
43
Approved as Treatment by the FDA
Abiraterone, commonly known as Zytiga, is approved by the FDA for 6 uses such as Castration and Prostatic Neoplasms .Castration
Used to treat Metastatic Castration Resistant Prostate Cancer (CRPC) in combination with Methylprednisolone
Prostatic Neoplasms
Used to treat High Risk Prostate Cancer in combination with Prednisone
Malignant Neoplasms
Used to treat Metastatic Castration Sensitive Prostate Cancer in combination with Prednisone
Metastatic Castration Resistant Prostate Cancer (CRPC)
Used to treat Metastatic Castration Resistant Prostate Cancer (CRPC) in combination with Methylprednisolone
Metastatic Castration Sensitive Prostate Cancer
Used to treat Metastatic Castration Sensitive Prostate Cancer in combination with Prednisone
High Risk Prostate Cancer
Used to treat High Risk Prostate Cancer in combination with Prednisone
Effectiveness
How Zytiga Affects PatientsAbiraterone is linked to decreases in PSA levels and tumor size, as well as lessening of bone metastases and pain relief. Taking this drug may cause an increase in hormones related to the adrenal glands, but this can be prevented by taking the steroid dexamethasone.
How Zytiga works in the bodyAbiraterone is a drug that works to lower the amount of testosterone in the body. It does this by blocking an enzyme called CYP17A1, which helps the body create testosterone. By blocking the enzyme, it prevents the body from producing testosterone and lowers the amount of testosterone in the body.
When to interrupt dosage
The suggested dosage of Zytiga is contingent upon the diagnosed health state. The dose varies, based on the administration approach outlined in the table beneath.Condition
Dosage
Administration
Castration
250.0 mg, , 500.0 mg, 125.0 mg, 1000.0 mg
, Oral, Tablet, Tablet - Oral, Tablet, film coated, Tablet, film coated - Oral
Prostatic Neoplasms
250.0 mg, , 500.0 mg, 125.0 mg, 1000.0 mg
, Oral, Tablet, Tablet - Oral, Tablet, film coated, Tablet, film coated - Oral
Malignant Neoplasms
250.0 mg, , 500.0 mg, 125.0 mg, 1000.0 mg
, Oral, Tablet, Tablet - Oral, Tablet, film coated, Tablet, film coated - Oral
Warnings
There are 20 known major drug interactions with Zytiga.Common Zytiga Drug Interactions
Drug Name
Risk Level
Description
Brigatinib
Major
The metabolism of Brigatinib can be decreased when combined with Abiraterone.
Cabazitaxel
Major
The metabolism of Cabazitaxel can be decreased when combined with Abiraterone.
Eliglustat
Major
The metabolism of Eliglustat can be decreased when combined with Abiraterone.
Fentanyl
Major
The metabolism of Fentanyl can be decreased when combined with Abiraterone.
Paclitaxel
Major
The metabolism of Paclitaxel can be decreased when combined with Abiraterone.
Zytiga Toxicity & Overdose RiskOverdosing on this drug can cause a disruption of the body's 17α-hydroxylase activity, leading to high levels of a mineralocorticoid called 11-deoxycorticosterone. This can cause water retention and low potassium levels in the blood. To counteract these symptoms, mineralocorticoid receptor antagonists can be prescribed.
Zytiga Novel Uses: Which Conditions Have a Clinical Trial Featuring Zytiga?
30 ongoing clinical trials are investigating the potential of Zytiga to manage Castration-Resistant Prostate Cancer.Condition
Clinical Trials
Trial Phases
Castration
29 Actively Recruiting
Phase 1, Phase 2, Phase 3
Prostatic Neoplasms
2 Actively Recruiting
Phase 2, Early Phase 1
Malignant Neoplasms
2 Actively Recruiting
Phase 3, Phase 1
Zytiga Reviews: What are patients saying about Zytiga?
5Patient Review
5/15/2013 Zytiga has been an absolute lifesaver for my husband. In just five months, his PSA levels have decreased from 1000 to 62 with no negative side effects that we've seen. This drug has given him back a quality of life that was rapidly deteriorating due to chemotherapy. We've been treating his stage 4 cancer for 11 years now, and this is by far the most promising treatment we've tried.
5Patient Review
7/24/2013 I started quarterly lupron injections at my doctor's suggestion. They worked for a while, but then my PSA started rising again. My doctor put me on Zytiga, and within the first month my PSA went from 135 to 3.5. Two months later it was down to 0.3. This medication has been a life-saver!
5Patient Review
7/24/2013 Lupron injections were initially effective for six months, but failed to address my continuing high PSA. My doctor then put me on Zytiga, and within the first 30 days my PSA went from 135 to 3.5. 60 days later it was down to 0.3.
5Patient Review
5/15/2013 Zytiga has been amazing for my husband. In only five months, it's brought his PSA levels down from over 1000 to 62. He hasn't experienced any negative side effects and it's given him back a much better quality of life. We're so grateful that this treatment option was available to us.
5Patient Review
9/27/2013 I have been taking this medication for two months with great success. My PSA levels dropped significantly, and I haven't experienced any negative side effects. The only downside is the cost--it can get pretty pricey.
Patient Q&A Section about zytiga
These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.How long do you take Zytiga?
"Many people with prostate cancer must take Zytiga for 2-3 years, resulting in hundreds of thousands of dollars in treatment costs."
Answered by AI
How long can you survive Zytiga?
"Patients who took Zytiga had an average lifespan of 35.3 months, while those who took the placebo only lived for 30.1 months on average."
Answered by AI
What are the side effects of Zytiga?
"If you are feeling any of the following symptoms, you may be experiencing menopause: fatigue, joint pain, high blood pressure, nausea, leg or feet swelling, low blood potassium levels, hot flushes, diarrhea."
Answered by AI
What is the side effect of Zytiga?
"ZYTIGA® may cause some serious side effects. These include high blood pressure, low potassium levels in the blood, fluid retention, and irregular heartbeats."
Answered by AI
Is Zytiga a form of chemotherapy?
"Zytiga (abiraterone acetate) is used to treat men with metastasized prostate cancer, alongside prednisone. It is not a form of chemotherapy, despite being used to treat cancer."
Answered by AI
What does the drug Zytiga do?
"ZYTIGA is a prescription medication that is to be used in conjunction with prednisone. It is specifically meant to treat prostate cancer that has spread to other areas of the body in male patients."
Answered by AI
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