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What is Tigan
TrimethobenzamideThe Generic name of this drug
Treatment SummaryTrimethobenzamide is a drug used to prevent nausea and vomiting in humans. The exact way it works is not known, but it may affect the chemoreceptor trigger zone in the brain. Studies in dogs have shown that trimethobenzamide can protect against nausea caused by certain drugs, but has no effect on nausea caused by copper sulfate.
Tiganis the brand name
Tigan Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Tigan
Trimethobenzamide
1974
37
Approved as Treatment by the FDA
Trimethobenzamide, otherwise known as Tigan, is approved by the FDA for 4 uses which include Operative Surgery and Nausea .Operative Surgery
Nausea
Gastrointestinal distress
Gastroenteritis
Effectiveness
How Tigan Affects PatientsTrimethobenzamide is a drug used to stop nausea and vomiting in humans. The exact way it works is unknown, but it is thought to target a certain area in the brain (the chemoreceptor trigger zone). In tests on dogs, trimethobenzamide was found to be effective at preventing vomiting caused by apomorphine, but not vomiting caused by copper sulfate.
How Tigan works in the bodyThe exact way trimethobenzamide works is unknown, but it may target the part of the brain responsible for causing nausea and vomiting. It appears to block signals that lead to vomiting, but does not stop direct impulses from getting through.
When to interrupt dosage
The proposed dosage of Tigan is contingent upon the diagnosed condition, such as Nausea, Pregnancy and Operative Surgery. The total amount of dosage fluctuates as per the technique of delivery (e.g. Injection or Suppository - Rectal) documented in the table beneath.Condition
Dosage
Administration
Operative Surgery
300.0 mg, , 100.0 mg/mL, 200.0 mg, 200.0 mg/mL, 100.0 mg, 10.0 mg/mL
, Oral, Capsule, Capsule - Oral, Intramuscular, Injection, Injection - Intramuscular, Injection, solution, Injection, solution - Intramuscular, Rectal, Suppository, Suppository - Rectal
Gastrointestinal distress
300.0 mg, , 100.0 mg/mL, 200.0 mg, 200.0 mg/mL, 100.0 mg, 10.0 mg/mL
, Oral, Capsule, Capsule - Oral, Intramuscular, Injection, Injection - Intramuscular, Injection, solution, Injection, solution - Intramuscular, Rectal, Suppository, Suppository - Rectal
Gastroenteritis
300.0 mg, , 100.0 mg/mL, 200.0 mg, 200.0 mg/mL, 100.0 mg, 10.0 mg/mL
, Oral, Capsule, Capsule - Oral, Intramuscular, Injection, Injection - Intramuscular, Injection, solution, Injection, solution - Intramuscular, Rectal, Suppository, Suppository - Rectal
Nausea
300.0 mg, , 100.0 mg/mL, 200.0 mg, 200.0 mg/mL, 100.0 mg, 10.0 mg/mL
, Oral, Capsule, Capsule - Oral, Intramuscular, Injection, Injection - Intramuscular, Injection, solution, Injection, solution - Intramuscular, Rectal, Suppository, Suppository - Rectal
Warnings
There are 20 known major drug interactions with Tigan.Common Tigan Drug Interactions
Drug Name
Risk Level
Description
Azelastine
Major
Trimethobenzamide may increase the central nervous system depressant (CNS depressant) activities of Azelastine.
Ethanol
Major
Trimethobenzamide may increase the central nervous system depressant (CNS depressant) activities of Ethanol.
Oliceridine
Major
The risk or severity of hypotension, sedation, death, somnolence, and respiratory depression can be increased when Trimethobenzamide is combined with Oliceridine.
Thalidomide
Major
Trimethobenzamide may increase the central nervous system depressant (CNS depressant) activities of Thalidomide.
Daridorexant
Minor
The risk or severity of CNS depression can be increased when Trimethobenzamide is combined with Daridorexant.
Tigan Toxicity & Overdose RiskThe lowest toxic dose of the drug in mice has been found to be 1600 mg/kg.
Tigan Novel Uses: Which Conditions Have a Clinical Trial Featuring Tigan?
156 active clinical trials are currently underway to discern whether Tigan is efficacious in treating Gastroenteritis, Operative Surgery and Pregnancy-related ailments.Condition
Clinical Trials
Trial Phases
Operative Surgery
84 Actively Recruiting
Not Applicable, Phase 3, Phase 4, Phase 2, Phase 1
Gastroenteritis
7 Actively Recruiting
Phase 2, Phase 3, Not Applicable, Phase 1
Nausea
0 Actively Recruiting
Gastrointestinal distress
20 Actively Recruiting
Not Applicable, Phase 2, Phase 4, Phase 1, Phase 3, Early Phase 1
Tigan Reviews: What are patients saying about Tigan?
5Patient Review
8/7/2013 Tigan has been a life-saver for me. I have chronic nausea from gastroparesis, and this is the only medication that helps. Even when I feel like I'm going to vomit, Tigan always prevents it.
5Patient Review
5/5/2008 This is by far the best treatment for nausea that I have ever tried. The other options, like Reglan, Promethazine, Compazine, and Zopran don't even come close to this medication. Yes, the sedative effect is slightly higher, but when you're sick who cares if you're a little drowsy when the nausea is gone and it's not coming back for a long time?
5Patient Review
8/16/2009 Love it. Works very well for me. (ESRD patient) Is available as a generic very inexpensively.
5Patient Review
2/15/2012 This medication was very effective at curbing my nausea and keeping me from vomiting.
5Patient Review
4/1/20085Patient Review
4/10/20084.7Patient Review
12/2/2008 Nausea is the only side effect I've experienced with this medication, and it's been incredibly effective otherwise. I was told it's being discontinued soon, which is really unfortunate.
4Patient Review
11/24/2009 Tigan has been really helpful for me during detox. I'm curious about what other conditions it is used to treat and if there are any over-the-counter alternatives.
4Patient Review
1/23/2017 Being highly allergic to compazine, this is one of the only treatments I can take. Thankfully, it works pretty well for me!
3.3Patient Review
9/10/2013 This drug helped me with my nausea, though only moderately. It also took about an hour to start working and made me drowsy. The manufacturer has decided to stop making this drug for financial reasons, not medical ones.
3.3Patient Review
2/7/2013 I was on Chemotherapy when I used this drug and it worked great.
3.3Patient Review
8/21/2013 Even though the vomiting has stopped, I'm still feeling nauseous.
2.7Patient Review
3/18/2011 I went to urgent care and found out that I have gastritis. They gave me a shot of tigan, which has finally allowed me to eat without vomiting or any other problems.
Patient Q&A Section about tigan
These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.What's the generic name for Tigan?
"The oral medication trimethobenzamide is used to treat nausea and vomiting."
Answered by AI
Is Tigan still available?
"All generic forms of trimethobenzamide have been discontinued and will no longer be available after May 2021. Trimethobenzamide injection is not affected and will still be available."
Answered by AI
What is Tigan used for?
"Trimethobenzamide is a medication used to treat nausea and vomiting. It is most commonly used to treat vomiting that may occur after surgery, but can also be used to treat gastroenteritis. Trimethobenzamide is not recommended for use in children due to the risk of serious side effects."
Answered by AI
What class of drug is Tigan?
"Antiemetic Agents are a class of drugs used to relieve nausea and vomiting. Tigan is one such drug."
Answered by AI