Tigan

Gastrointestinal distress, Gastroenteritis, Operative Surgery + 1 more
Treatment
6 FDA approvals
20 Active Studies for Tigan

What is Tigan

TrimethobenzamideThe Generic name of this drug
Treatment SummaryTrimethobenzamide is a drug used to prevent nausea and vomiting in humans. The exact way it works is not known, but it may affect the chemoreceptor trigger zone in the brain. Studies in dogs have shown that trimethobenzamide can protect against nausea caused by certain drugs, but has no effect on nausea caused by copper sulfate.
Tiganis the brand name
image of different drug pills on a surface
Tigan Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Tigan
Trimethobenzamide
1974
37

Approved as Treatment by the FDA

Trimethobenzamide, otherwise known as Tigan, is approved by the FDA for 6 uses which include Nausea and vomiting and Gastroenteritis .
Nausea and vomiting
Gastroenteritis
Gastrointestinal distress
Operative Surgery
Nausea
Gastroenteritis

Effectiveness

How Tigan Affects PatientsTrimethobenzamide is a drug used to stop nausea and vomiting in humans. The exact way it works is unknown, but it is thought to target a certain area in the brain (the chemoreceptor trigger zone). In tests on dogs, trimethobenzamide was found to be effective at preventing vomiting caused by apomorphine, but not vomiting caused by copper sulfate.
How Tigan works in the bodyThe exact way trimethobenzamide works is unknown, but it may target the part of the brain responsible for causing nausea and vomiting. It appears to block signals that lead to vomiting, but does not stop direct impulses from getting through.

When to interrupt dosage

The proposed dosage of Tigan is contingent upon the diagnosed condition, such as Nausea, Pregnancy and Operative Surgery. The total amount of dosage fluctuates as per the technique of delivery (e.g. Injection or Suppository - Rectal) documented in the table beneath.
Condition
Dosage
Administration
Gastrointestinal distress
300.0 mg, , 100.0 mg/mL, 200.0 mg, 200.0 mg/mL, 100.0 mg, 10.0 mg/mL
, Oral, Capsule, Capsule - Oral, Intramuscular, Injection, Injection - Intramuscular, Injection, solution, Injection, solution - Intramuscular, Rectal, Suppository, Suppository - Rectal
Gastroenteritis
300.0 mg, , 100.0 mg/mL, 200.0 mg, 200.0 mg/mL, 100.0 mg, 10.0 mg/mL
, Oral, Capsule, Capsule - Oral, Intramuscular, Injection, Injection - Intramuscular, Injection, solution, Injection, solution - Intramuscular, Rectal, Suppository, Suppository - Rectal
Operative Surgery
300.0 mg, , 100.0 mg/mL, 200.0 mg, 200.0 mg/mL, 100.0 mg, 10.0 mg/mL
, Oral, Capsule, Capsule - Oral, Intramuscular, Injection, Injection - Intramuscular, Injection, solution, Injection, solution - Intramuscular, Rectal, Suppository, Suppository - Rectal
Nausea
300.0 mg, , 100.0 mg/mL, 200.0 mg, 200.0 mg/mL, 100.0 mg, 10.0 mg/mL
, Oral, Capsule, Capsule - Oral, Intramuscular, Injection, Injection - Intramuscular, Injection, solution, Injection, solution - Intramuscular, Rectal, Suppository, Suppository - Rectal

Warnings

There are 20 known major drug interactions with Tigan.
Common Tigan Drug Interactions
Drug Name
Risk Level
Description
Azelastine
Major
Trimethobenzamide may increase the central nervous system depressant (CNS depressant) activities of Azelastine.
Ethanol
Major
Trimethobenzamide may increase the central nervous system depressant (CNS depressant) activities of Ethanol.
Oliceridine
Major
The risk or severity of hypotension, sedation, death, somnolence, and respiratory depression can be increased when Trimethobenzamide is combined with Oliceridine.
Thalidomide
Major
Trimethobenzamide may increase the central nervous system depressant (CNS depressant) activities of Thalidomide.
Daridorexant
Minor
The risk or severity of CNS depression can be increased when Trimethobenzamide is combined with Daridorexant.
Tigan Toxicity & Overdose RiskThe lowest toxic dose of the drug in mice has been found to be 1600 mg/kg.
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Tigan Novel Uses: Which Conditions Have a Clinical Trial Featuring Tigan?

156 active clinical trials are currently underway to discern whether Tigan is efficacious in treating Gastroenteritis, Operative Surgery and Pregnancy-related ailments.
Condition
Clinical Trials
Trial Phases
Gastrointestinal distress
9 Actively Recruiting
Phase 2, Early Phase 1, Phase 1, Phase 3, Not Applicable, Phase 4
Nausea
0 Actively Recruiting
Gastroenteritis
1 Actively Recruiting
Not Applicable
Operative Surgery
75 Actively Recruiting
Phase 3, Not Applicable, Phase 4, Phase 1, Phase 2, Early Phase 1

Tigan Reviews: What are patients saying about Tigan?

5Patient Review
8/7/2013
Tigan for Feel Like Throwing Up
Tigan has been a life-saver for me. I have chronic nausea from gastroparesis, and this is the only medication that helps. Even when I feel like I'm going to vomit, Tigan always prevents it.
5Patient Review
5/5/2008
Tigan for Nausea and Vomiting
This is by far the best treatment for nausea that I have ever tried. The other options, like Reglan, Promethazine, Compazine, and Zopran don't even come close to this medication. Yes, the sedative effect is slightly higher, but when you're sick who cares if you're a little drowsy when the nausea is gone and it's not coming back for a long time?
5Patient Review
8/16/2009
Tigan for Nausea and Vomiting
Love it. Works very well for me. (ESRD patient) Is available as a generic very inexpensively.
5Patient Review
2/15/2012
Tigan for Nausea and Vomiting
This medication was very effective at curbing my nausea and keeping me from vomiting.
5Patient Review
4/1/2008
Tigan for Nausea and Vomiting
5Patient Review
4/10/2008
Tigan for Nausea and Vomiting
4.7Patient Review
12/2/2008
Tigan for Nausea and Vomiting
Nausea is the only side effect I've experienced with this medication, and it's been incredibly effective otherwise. I was told it's being discontinued soon, which is really unfortunate.
4Patient Review
11/24/2009
Tigan for Nausea and Vomiting
Tigan has been really helpful for me during detox. I'm curious about what other conditions it is used to treat and if there are any over-the-counter alternatives.
4Patient Review
1/23/2017
Tigan for Nausea and Vomiting
Being highly allergic to compazine, this is one of the only treatments I can take. Thankfully, it works pretty well for me!
3.3Patient Review
9/10/2013
Tigan for Nausea and Vomiting
This drug helped me with my nausea, though only moderately. It also took about an hour to start working and made me drowsy. The manufacturer has decided to stop making this drug for financial reasons, not medical ones.
3.3Patient Review
2/7/2013
Tigan for Nausea and Vomiting
I was on Chemotherapy when I used this drug and it worked great.
3.3Patient Review
8/21/2013
Tigan for Nausea and Vomiting
Even though the vomiting has stopped, I'm still feeling nauseous.
2.7Patient Review
3/18/2011
Tigan for Nausea and Vomiting
I went to urgent care and found out that I have gastritis. They gave me a shot of tigan, which has finally allowed me to eat without vomiting or any other problems.
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Patient Q&A Section about tigan

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

What's the generic name for Tigan?

"The oral medication trimethobenzamide is used to treat nausea and vomiting."

Answered by AI

Is Tigan still available?

"All generic forms of trimethobenzamide have been discontinued and will no longer be available after May 2021. Trimethobenzamide injection is not affected and will still be available."

Answered by AI

What is Tigan used for?

"Trimethobenzamide is a medication used to treat nausea and vomiting. It is most commonly used to treat vomiting that may occur after surgery, but can also be used to treat gastroenteritis. Trimethobenzamide is not recommended for use in children due to the risk of serious side effects."

Answered by AI

What class of drug is Tigan?

"Antiemetic Agents are a class of drugs used to relieve nausea and vomiting. Tigan is one such drug."

Answered by AI

Clinical Trials for Tigan

Image of Washington University / Barnes Jewish Hospital in St Louis, United States.

AI-Driven Clinical Decision Support for Surgery

18+
All Sexes
St Louis, MO
20 million patients have surgery in the United States every year, with approximately 1 million of those patients requiring life-saving blood transfusion. Presurgical preparation for transfusion is important to allow for safe and timely transfusion during surgery; however, excessive preparation is unfortunately common, costly, and contributes to blood waste. This study aims to evaluate an intelligent clinical decision support system that helps clinicians prepare blood for patients who are likely to need it, while avoiding excessive preparation for patients who don't, potentially improving patient safety while reducing blood waste and healthcare costs.
Recruiting
Has No Placebo
Washington University / Barnes Jewish Hospital
Image of UPMC Shadyside Hospital in Pittsburgh, United States.

Bright Green Light Therapy for Postoperative Pain

18+
All Sexes
Pittsburgh, PA
This is an unblinded, parallel group randomized controlled trial to evaluate bright green light as an adjunct therapy after surgery at UPMC Shadyside. The primary outcome measure will be pain intensity with secondary outcome measures including opioid requirements, sleep quality, mood, and overall post-operative recovery. Specific aims/hypotheses for this study are as follows: Aim 1: To assess bright green light therapy's potential as a complementary post-operative analgesic strategy in patients recovering from surgery Hypothesis 1: Participants exposed to bright green light, in comparison to dim white (ambient) light, will have improved postoperative pain scores and lower opioid use. Aim 2: To examine the impact of bright green light therapy on patient-centered measures of post-operative recovery that may be related to improved circadian function. Hypothesis 2: Participants exposed to bright green light, in comparison to dim white (ambient) light, will have improved quality of post-operative recovery, enhanced sleep, and reduced anxiety and depression.
Waitlist Available
Has No Placebo
UPMC Shadyside HospitalRebecca Kotcher, MD
Image of Walter Reed National Military Medical Center in Bethesda, United States.

Corticosteroid Injections for Osteoarthritis

18+
All Sexes
Bethesda, MD
The goal of this clinical trial is to find out which type of steroid medicine, when added to a standard pain-control injection during total knee replacement surgery, works best at reducing pain, limiting opioid use, and improving recovery in adults undergoing surgery for severe knee arthritis or injury. The main questions it aims to answer are: Does adding a steroid to the injection improve pain control and reduce opioid use after surgery? Is the newer extended-release steroid (Zilretta) more effective and safer-especially for patients with diabetes-than the traditional steroid (methylprednisolone)? Researchers will compare: Standard pain-control injection alone Standard injection plus methylprednisolone Standard injection plus Zilretta to see which option provides better pain relief, less opioid use, and improved knee function. (Patients with diabetes or prediabetes will only be in the standard injection or Zilretta groups so researchers can study whether Zilretta is safer for blood sugar control.) Participants will: Be randomly assigned to one of the study groups during their total knee replacement surgery Receive the assigned pain-control injection around the knee joint Be followed after surgery to measure: Pain levels Opioid pain medication use Knee movement (range of motion) Whether another procedure (such as manipulation under anesthesia) is needed if the knee becomes too stiff Patient-reported outcome surveys about pain and function
Phase 2 & 3
Waitlist Available
Walter Reed National Military Medical CenterJohn P Cody, MD
Have you considered Tigan clinical trials? We made a collection of clinical trials featuring Tigan, we think they might fit your search criteria.Go to Trials
Image of Nationwide Children's Hospital in Columbus, United States.

Surface Electromyography for Surgery

No minimum age - 21
All Sexes
Columbus, OH
The investigators are studying a type of technology that is already used called surface electromyography (EMG). This measures and records electrical activity using sensor stickers in a non-invasive way. The purpose of this study is to use a prototype/test surface EMG machine to measure how well regional anesthesia (nerve block) is working. This device is non-invasive and being used for research use as an unapproved medical device. The information may teach us how to give nerve blocks more safely and effectively. Study participation: Subjects having surgery will have the surface EMG sensor stickers placed on their arms or legs before surgery. These will stay on during surgery and for part of recovery. Study visits: The study will consist of 1 visit that starts in the pre-operative area, through the surgery, and for part of recovery time after surgery.
Waitlist Available
Has No Placebo
Nationwide Children's HospitalGrant Heydinger, MD
Have you considered Tigan clinical trials? We made a collection of clinical trials featuring Tigan, we think they might fit your search criteria.Go to Trials
Image of CHU de Québec-Université Laval (Hôpital de l'Enfant-Jésus) in Québec, Canada.

Lidocaine + Dexmedetomidine for Surgery Outcomes

18+
All Sexes
Québec, Canada
Up to 40% of patients experience suboptimal recovery in the days following major surgery, limiting their return to functional independence. Few preventive interventions exist, but intravenous dexmedetomidine and lidocaine administered during general anesthesia represent simple strategies that may significantly impact recovery and other patient-centred outcomes after surgery. The goal of this pilot trial is to determine the feasibility of conducting a phase 3 pragmatic adaptive multicentre trial to evaluate the impact of dexmedetomidine and lidocaine administered during major non-cardiac surgery on patient-centred outcomes.
Recruiting
Has No Placebo
CHU de Québec-Université Laval (Hôpital de l'Enfant-Jésus)Michael Verret, MD PhD FRCPC
Image of University Health Network in Toronto, Canada.

Sleep Prehabilitation for Surgery

18+
All Sexes
Toronto, Canada
The goal of this clinical trial is to learn if changing sleep behaviour can improve sleep health in patients undergoing prehabilitation before elective surgery. Prehabilitation is the use of exercise, nutrition, and psychological support before surgery to improve recovery from surgery. The main questions it aims to answer are: Does changing sleep behaviour improve sleep before surgery? Does changing sleep behaviour improve recovery after surgery? Researchers will compare participants who receive sleep support with participants who do not receive sleep support to see if it improves sleep health and recovery from surgery. Participants will be asked to attend 4 meetings with the research team to learn how they can improve their sleep. They will use questionnaires, a diary, and a wearable tracker to record their sleep.
Recruiting
Has No Placebo
University Health NetworkIan Randall, MD
Image of Montefiore Medical Center in Bronx, United States.

Fosaprepitant vs Metoclopramide for Nausea and Vomiting

18+
All Sexes
Bronx, NY
The study team proposes a double-blind, comparative effectiveness, randomized controlled trial (RCT) to address the following goal: to determine the relative efficacy and adverse event profile of fosaprepitant compared to the standard of care antiemetic metoclopramide. Fosaprepitant and its active metabolite aprepitant are a relatively new class of antiemetic that exclusively acts in the central nervous system by blocking neurokinin (NK-1) which is a key signaling molecule in the centrally mediated aspects of the vomiting reflex. Currently, fosaprepitant and aprepitant both have only two United Stated Food and Drug Administration (USFDA) approved indications for nausea and vomiting: chemotherapy-induced and postoperative. Neurokinin inhibitors are highly effective and generally well-tolerated. Therefore, this class of medication may be a more appropriate medication for the millions of patients with nausea and vomiting that seek care in emergency departments (EDs). Intravenous fosaprepitant is converted to the active metabolite aprepitant on the order of minutes and is significantly cheaper to procure at this time.
Phase 4
Waitlist Available
Montefiore Medical Center (+1 Sites)Benjamin Friedman, MD
Have you considered Tigan clinical trials? We made a collection of clinical trials featuring Tigan, we think they might fit your search criteria.Go to Trials
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