Kytril

Chemotherapy, Operative Surgery, Nausea + 1 more
Treatment
2 FDA approvals
20 Active Studies for Kytril

What is Kytril

GranisetronThe Generic name of this drug
Treatment SummaryOndansetron is a medication used to prevent nausea and vomiting in cancer patients undergoing chemotherapy. It works by blocking the action of serotonin, a chemical messenger in the brain that can trigger nausea and vomiting.
Kytrilis the brand name
Kytril Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Kytril
Granisetron
1993
63

Approved as Treatment by the FDA

Granisetron, also known as Kytril, is approved by the FDA for 2 uses such as Chemotherapy and Nausea .
Chemotherapy
Nausea

Effectiveness

How Kytril Affects PatientsGranisetron is a drug that targets serotonin receptors, specifically type 3 serotonergic receptors. It does not affect other serotonin receptors, nor does it have an effect on blood pressure, heart rate, or electrocardiogram (ECG). It works similarly to another drug called ondansetron. When chemotherapy drugs are used, they may damage the lining of the digestive tract and cause the release of serotonin. This serotonin stimulates certain nerves in the brain, leading to nausea and vomiting. Granisetron works by blocking serotonin receptors to prevent this reaction.
How Kytril works in the bodyGranisetron works by blocking serotonin receptors that are present in the brain and stomach. Blocking these receptors prevents them from sending signals to the area of the brain responsible for vomiting, reducing the risk of nausea and vomiting.

When to interrupt dosage

The proposed portion of Kytril is contingent upon the determined disorder, for instance Nausea, Radiation Therapy and Operative Surgery. The amount of dosage fluctuates, as per the method of delivery (e.g. Solution - Oral or Injection, solution) detailed in the following table.
Condition
Dosage
Administration
Radiation Therapy
, 1.0 mg/mL, 0.1 mg/mL, 1.0 mg, 0.31 mg/hour, 4.0 mg/mL, 100.0 mg/mL, 1.12 mg/mL, 0.2 mg/mL
, Intravenous, Injection, Injection - Intravenous, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Patch, Patch - Transdermal, Transdermal, Injection, solution, Injection, solution - Intravenous, Liquid, Liquid - Intravenous, Solution, Solution - Intravenous, Subcutaneous, Injection - Subcutaneous, Solution - Oral
Chemotherapy
, 1.0 mg/mL, 0.1 mg/mL, 1.0 mg, 0.31 mg/hour, 4.0 mg/mL, 100.0 mg/mL, 1.12 mg/mL, 0.2 mg/mL
, Intravenous, Injection, Injection - Intravenous, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Patch, Patch - Transdermal, Transdermal, Injection, solution, Injection, solution - Intravenous, Liquid, Liquid - Intravenous, Solution, Solution - Intravenous, Subcutaneous, Injection - Subcutaneous, Solution - Oral
Operative Surgery
, 1.0 mg/mL, 0.1 mg/mL, 1.0 mg, 0.31 mg/hour, 4.0 mg/mL, 100.0 mg/mL, 1.12 mg/mL, 0.2 mg/mL
, Intravenous, Injection, Injection - Intravenous, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Patch, Patch - Transdermal, Transdermal, Injection, solution, Injection, solution - Intravenous, Liquid, Liquid - Intravenous, Solution, Solution - Intravenous, Subcutaneous, Injection - Subcutaneous, Solution - Oral
Nausea
, 1.0 mg/mL, 0.1 mg/mL, 1.0 mg, 0.31 mg/hour, 4.0 mg/mL, 100.0 mg/mL, 1.12 mg/mL, 0.2 mg/mL
, Intravenous, Injection, Injection - Intravenous, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Patch, Patch - Transdermal, Transdermal, Injection, solution, Injection, solution - Intravenous, Liquid, Liquid - Intravenous, Solution, Solution - Intravenous, Subcutaneous, Injection - Subcutaneous, Solution - Oral

Warnings

There are 20 known major drug interactions with Kytril.
Common Kytril Drug Interactions
Drug Name
Risk Level
Description
Anagrelide
Major
The risk or severity of QTc prolongation can be increased when Granisetron is combined with Anagrelide.
Apomorphine
Major
The risk or severity of hypotension can be increased when Granisetron is combined with Apomorphine.
Arsenic trioxide
Major
The risk or severity of QTc prolongation can be increased when Granisetron is combined with Arsenic trioxide.
Artemether
Major
The risk or severity of QTc prolongation can be increased when Granisetron is combined with Artemether.
Asenapine
Major
The risk or severity of QTc prolongation can be increased when Granisetron is combined with Asenapine.
Kytril Toxicity & Overdose RiskThe lowest toxic dose of this drug in rats has been found to be greater than 2000mg/kg when taken orally.
image of a doctor in a lab doing drug, clinical research

Kytril Novel Uses: Which Conditions Have a Clinical Trial Featuring Kytril?

85 active trials are currently being conducted to investigate the potential of Kytril to mitigate Nausea, Operative Surgery and Radiation Therapy.
Condition
Clinical Trials
Trial Phases
Operative Surgery
81 Actively Recruiting
Not Applicable, Phase 3, Phase 4, Phase 2, Phase 1
Radiation Therapy
5 Actively Recruiting
Not Applicable, Phase 1, Phase 3
Nausea
0 Actively Recruiting
Chemotherapy
2 Actively Recruiting
Not Applicable

Kytril Reviews: What are patients saying about Kytril?

5Patient Review
5/5/2010
Kytril for Nausea and Vomiting
This drug was a life-saver for me when I was going through chemotherapy. It completely alleviated my nausea and vomiting. I would highly recommend it to anyone else undergoing cancer treatment.
5Patient Review
11/20/2008
Kytril for Prevent Nausea and Vomiting from Cancer Chemotherapy
This drug helped control my nausea much more than anything else I have tried. I still had no appetite but did not feel nauseous or vomit at all.
5Patient Review
11/17/2009
Kytril for Nausea and Vomiting
This treatment has been essential for me and I can't imagine living without it.
5Patient Review
9/18/2009
Kytril for Prevent Nausea and Vomiting from Cancer Chemotherapy
This treatment is effective.
5Patient Review
11/18/2009
Kytril for Prevent Nausea and Vomiting from Cancer Chemotherapy
This was the only treatment that helped me with my severe vomiting and nausea when I was pregnant with my daughter. It allowed me to lead a normal life, which was a huge relief.
5Patient Review
7/18/2020
Kytril for Nausea and Vomiting caused by Cancer Drugs
Super effective!
4.7Patient Review
5/6/2010
Kytril for Prevent Nausea and Vomiting from Cancer Chemotherapy
This treatment has been a lifesaver. I don't know what I would do without it.
4Patient Review
11/18/2008
Kytril for Nausea and Vomiting caused by Cancer Drugs
image of drug pills surrounding a glass of water symbolizing drug consumption

Patient Q&A Section about kytril

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Is Kytril the same as Zofran?

"Glaxo's Zofran and SmithKline Beecham's Kytril are both effective in controlling chemotherapy-induced nausea and vomiting in lung cancer patients at the recommended doses."

Answered by AI

What does Kytril treat?

"This drug is used to prevent vomiting and nausea caused by cancer treatments like chemotherapy and radiation therapy. It works by blocking out serotonin, one of the body's chemicals that causes vomiting."

Answered by AI

How long does Kytril take to work?

"In the ferret animal model, a single injection of granisetron prevented vomiting due to high-dose cisplatin, or stopped vomiting within 5 to 30 seconds. In most human studies, granisetron has had little effect on blood pressure, heart rate or ECG."

Answered by AI

When should I take Kytril?

"The dosage of KYTRIL tablets for the prevention of nausea and vomiting associated with chemotherapy is typically one 2 mg tablet once a day, taken within one hour before the start of chemotherapy. This dosage may be taken for up to one week following chemotherapy."

Answered by AI

Clinical Trials for Kytril

Have you considered Kytril clinical trials? We made a collection of clinical trials featuring Kytril, we think they might fit your search criteria.
Have you considered Kytril clinical trials? We made a collection of clinical trials featuring Kytril, we think they might fit your search criteria.
Have you considered Kytril clinical trials? We made a collection of clinical trials featuring Kytril, we think they might fit your search criteria.