Nerve Block for Postoperative Pain

Overseen By Rodney A Gabriel, MD

Age: 18+

Sex: Any

Trial Phase: Phase 4

Sponsor: University of California, San Diego

Must not be taking: Opioids, Tramadol

Disqualifiers: Neuro-muscular deficit, Opioid misuse, others

No Placebo Group All trial participants will receive the active study treatment (no placebo)

Prior Safety Data This treatment has passed at least one previous human trial

Compensation: Varies

Number of Visits: 1

40 Participants Needed

What You Need to Know Before You Apply

What is the purpose of this trial?

This is a single-center pilot study to determine if an adductor canal continuous nerve block is superior to single injection nerve block following total knee arthroplasty. Investigators will randomize participants to either continuous nerve block or single injection nerve block for the adductor canal preoperatively. They will assess differences in pain (measured in numeric rating scale), opioid consumption, and physical therapy milestones from postoperative day 0 to 7.

Are You a Good Fit for This Trial?

This trial is for adults over 50 kg who are having their first knee replacement surgery and plan to receive a single-injection nerve block. It's not suitable for those with conditions that exclude them from the study, which aren't specified here.

Inclusion Criteria

I am 18 years old or older.

I am having a knee replacement surgery on one knee.

I am scheduled for a one-time nerve block in my thigh.

Exclusion Criteria

History of opioid misuse

Pregnancy

Inability to contact the investigators during the treatment period, and vice versa (e.g., lack of telephone access)

Timeline for a Trial Participant

Screening

Participants are screened for eligibility to participate in the trial

1-2 weeks

Preoperative

Participants receive either a single injection or a continuous adductor canal block with ropivacaine

1 day

1 visit (in-person)

Postoperative Treatment

Participants are monitored for pain, opioid consumption, and physical therapy milestones from postoperative day 0 to 7

7 days

Daily monitoring

Follow-up

Participants are assessed for pain scores, opioid consumption, and physical and emotional functioning at 30 days postoperatively

30 days

What Are the Treatments Tested in This Trial?

Interventions

• Adductor Canal Block

Trial Overview The study compares two types of pain control after knee surgery: one group gets a continuous nerve block through an OnQ pump, while the other receives a single injection. The goal is to see which method better reduces pain and opioid use, and helps patients reach physical therapy goals within the first week post-surgery.

How Is the Trial Designed?

Group I: Continuous adductor canal block Experimental Treatment 1 Intervention

single injection with ropivacaine (0.5%) of the adductor canal block and a 5-day continuous perineural infusion of ropivacaine (0.2%) (experimental group)

Group II: single injection adductor canal block Active Control 1 Intervention

single injection with ropivacaine (0.5%) of the adductor canal block and no continuous nerve block added

Who Is Running the Clinical Trial?

University of California, San Diego

Lead Sponsor

Trials

1,215

Recruited

1,593,000+