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Antiplatelet Agent

Cilostazol for Cerebral Small Vessel Disease

Phase 1 & 2
Recruiting
Led By Michelle P Lin, MD, MPH
Research Sponsored by Mayo Clinic
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Age ≥18 yo.
Be older than 18 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up 1 year
Awards & highlights

Study Summary

This trial will test whether a medication can help treat a disease that increases the risk of stroke and dementia in older adults.

Who is the study for?
This trial is for adults over 18 with cerebral small vessel disease (SVD) conditions like CADASIL or sporadic white matter diseases, and also includes healthy controls without SVD. It's not open to those under 18, pregnant or breastfeeding individuals, people who can't follow commands, or those unable to tolerate an MRI.Check my eligibility
What is being tested?
The study tests if cilostazol, a drug that prevents blood clots and widens blood vessels, can slow down the progression of SVD—a brain condition linked to stroke and dementia—and if changes in retina blood flow are indicators of SVD health.See study design
What are the potential side effects?
Cilostazol may cause headaches, diarrhea, palpitations (feeling your heart beat), dizziness when standing up too fast due to low blood pressure, and unusual bleeding or bruising.

Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below
Select...
I am 18 years old or older.

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~1 year
This trial's timeline: 3 weeks for screening, Varies for treatment, and 1 year for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
white matter disease volume
Secondary outcome measures
cerebrovasoreactivity
cognition
retinal vasoreactivity
+1 more

Side effects data

From 2009 Phase 4 trial • 457 Patients • NCT00130039
73%
others
27%
headache
12%
dizziness
7%
diarrhea
6%
epigastric soreness
4%
cerebral infarction
3%
depression
3%
palpitation
2%
gastroenteritis
2%
fracture or other joint pain
1%
aneurysm unruptured
1%
urticaria
1%
acute myocardial infarction
1%
GI bleeding
1%
edema
1%
diabetes complications
1%
cancer
1%
GI bleedings
1%
tachycardia
100%
80%
60%
40%
20%
0%
Study treatment Arm
Cilostazol
Clopidogrel

Trial Design

2Treatment groups
Experimental Treatment
Active Control
Group I: CilostazolExperimental Treatment1 Intervention
Cilostazol 100mg BID
Group II: No interventionActive Control1 Intervention
Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
Cilostazol
2012
Completed Phase 4
~6360

Find a Location

Logistics

Participation is compensated

You will be compensated for participating in this trial.

Who is running the clinical trial?

Mayo ClinicLead Sponsor
3,207 Previous Clinical Trials
3,767,040 Total Patients Enrolled
Michelle P Lin, MD, MPHPrincipal InvestigatorMayo Clinic
Michelle Lin, MD, MPHPrincipal InvestigatorMayo Clinic

Media Library

Cilostazol (Antiplatelet Agent) 2023 Treatment Timeline for Medical Study. Trial Name: NCT04753970 — Phase 1 & 2
Cerebral Small Vessel Disease Patient Testimony for trial: Trial Name: NCT04753970 — Phase 1 & 2

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Are there any unfilled vacancies for participants in this experiment?

"The information available on clinicaltrials.gov verifies that this study is currently looking for test subjects. This trial was originally posted on February 9th, 2021 and the most recent update was on July 26th, 2022. They are 100 patients needed from 1 location."

Answered by AI

What other research has been conducted on Cilostazol?

"Cilostazol, which is being trialled at 6 locations with 0 Phase 3 trials, is the focus of 6 active clinical studies. Most of these research sites for Cilostazol are situated in Shibīn Al Kawm, Menoufia."

Answered by AI

How many individuals are taking part in this experiment at most?

"Yes, this information is accurate. The online clinical trials database shows that the trial was originally posted on February 9th, 2021 and has since been updated on July 26th, 2022. They are looking for 100 patients to participate at 1 location."

Answered by AI

Who else is applying?

What state do they live in?
Arizona
South Carolina
Other
Massachusetts
How old are they?
18 - 65
What site did they apply to?
Mayo Clinic Florida
Mayo Clinic in Florida
What portion of applicants met pre-screening criteria?
Did not meet criteria
Met criteria
How many prior treatments have patients received?
0

What questions have other patients asked about this trial?

How long would I stay in Florida? Is there a cost to the patient? When will this take plce? Can I bring my wife? Do I get to know the results? Can I do anything feom home?
PatientReceived 2+ prior treatments

Why did patients apply to this trial?

I was told there was no treatment. I have had many tia's and strokes and I have 5 children who may also have cadasil!
PatientReceived 2+ prior treatments
I have had many tia's and strokes and I have 5 children who may also have cadasil. I.
PatientReceived 1 prior treatment
I have had many tia's and strokes and I have 5 children who may also have cadasil. I would.
PatientReceived no prior treatments
I have had many tia's and strokes and I have 5 children who may also have cadasil. I would.
PatientReceived 1 prior treatment

How responsive is this trial?

Typically responds via
Email
Most responsive sites:
  1. Mayo Clinic Florida: < 48 hours
  2. Mayo Clinic in Florida: < 48 hours
Average response time
  • < 2 Days
Recent research and studies
clinicaltrials.govStudy
Retina is a Marker for Cerebrovascular Heath
Michelle P. Lin 2021. "Retina is a Marker for Cerebrovascular Heath". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT04753970.
All > White Matter Disease > Cadasil
~40 spots leftby Jun 2026
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