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What is Zaditor
KetotifenThe Generic name of this drug
Treatment SummaryKetotifen is a medication used to treat allergies and allergic reactions. It was first developed in 1970 by Sandoz Pharmaceuticals and is now used in the U.S. as an over-the-counter ophthalmic product to relieve itchy eyes caused by allergies. In Canada, it is a prescription-only product prescribed to children with asthma. Oral ketotifen is also available in Mexico and Europe for other allergic symptoms and conditions such as hives, mastocytosis, and food allergies.
Allergy Eye Original Prescription Strengthis the brand name
Zaditor Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Allergy Eye Original Prescription Strength
Ketotifen
1995
104
Effectiveness
How Zaditor Affects PatientsKetotifen is a medication that helps to prevent asthma attacks by blocking the effects of substances that cause inflammation. It takes about 6-12 weeks for this drug to start working. Studies have found that ketotifen can reduce the number, intensity, and duration of asthma attacks, and may allow the use of fewer other medications for the condition.
How Zaditor works in the bodyKetotifen blocks allergic reactions in the body by blocking a type of cell receptor that reacts to histamine. It also helps to stabilize cells that release inflammatory mediators like histamine and leukotrienes, which can cause irritation and inflammation. Additionally, it has been observed that it helps to prevent airway hyperactivity, and stops eosinophils and platelets from accumulating in the airways. It also helps to reduce bronchoconstriction caused by leukotrienes, and suppresses priming of eosinophils.
When to interrupt dosage
The advised dosage of Zaditor is contingent upon the identified condition, including Asthma, Allergic, Allergic Conjunctivitis (AC) and Hay Fever. The measure of dosage fluctuates according to the method of delivery (e.g. Solution or Ophthalmic) featured in the table underneath.Condition
Dosage
Administration
Allergic Conjunctivitis (AC)
, 0.35 mg/mL, 0.25 mg/mL, 0.345 mg/mL, 250.0 mg/mL, 1.0 mg, 0.5 mg/mL, 1.0 mg/mL
, Ophthalmic, Solution, Solution - Ophthalmic, Solution / drops, Solution / drops - Ophthalmic, Oral, Tablet, Tablet - Oral, Syrup, Syrup - Oral, Solution / drops - Oral
Eye
, 0.35 mg/mL, 0.25 mg/mL, 0.345 mg/mL, 250.0 mg/mL, 1.0 mg, 0.5 mg/mL, 1.0 mg/mL
, Ophthalmic, Solution, Solution - Ophthalmic, Solution / drops, Solution / drops - Ophthalmic, Oral, Tablet, Tablet - Oral, Syrup, Syrup - Oral, Solution / drops - Oral
Seasonal Allergic Conjunctivitis
, 0.35 mg/mL, 0.25 mg/mL, 0.345 mg/mL, 250.0 mg/mL, 1.0 mg, 0.5 mg/mL, 1.0 mg/mL
, Ophthalmic, Solution, Solution - Ophthalmic, Solution / drops, Solution / drops - Ophthalmic, Oral, Tablet, Tablet - Oral, Syrup, Syrup - Oral, Solution / drops - Oral
Asthma, Allergic
, 0.35 mg/mL, 0.25 mg/mL, 0.345 mg/mL, 250.0 mg/mL, 1.0 mg, 0.5 mg/mL, 1.0 mg/mL
, Ophthalmic, Solution, Solution - Ophthalmic, Solution / drops, Solution / drops - Ophthalmic, Oral, Tablet, Tablet - Oral, Syrup, Syrup - Oral, Solution / drops - Oral
Warnings
Zaditor has two contraindications, so it should not be joined with the illnesses indicated in the following table.Zaditor ContraindicationsCondition
Risk Level
Notes
Severe Hypersensitivity Reactions
Do Not Combine
Ketotifen may interact with Pulse Frequency
Pulse Frequency
Do Not Combine
Common Zaditor Drug Interactions
Drug Name
Risk Level
Description
Pitolisant
Major
The therapeutic efficacy of Pitolisant can be decreased when used in combination with Ketotifen.
Benzylpenicilloyl polylysine
Moderate
Ketotifen may decrease effectiveness of Benzylpenicilloyl polylysine as a diagnostic agent.
Betahistine
Moderate
The therapeutic efficacy of Betahistine can be decreased when used in combination with Ketotifen.
Deoxyepinephrine
Moderate
The therapeutic efficacy of Deoxyepinephrine can be increased when used in combination with Ketotifen.
Droxidopa
Moderate
The therapeutic efficacy of Droxidopa can be increased when used in combination with Ketotifen.
Zaditor Toxicity & Overdose RiskTaking too much ketotifen may cause feelings of extreme drowsiness, confusion, fast heartbeat, low blood pressure, seizures, restlessness (especially in children), and unconsciousness. If the overdose occurred recently, a doctor may use stomach pumping or activated charcoal to reduce the amount of ketotifen in the body. Other treatments may include medicines to control seizures, and medicines to reduce the effects of anticholinergics.
Zaditor Novel Uses: Which Conditions Have a Clinical Trial Featuring Zaditor?
14 active clinical trials are assessing the potential of Zaditor to provide relief from Seasonal Allergic Conjunctivitis, Hay Fever, Allergic Asthma and other conditions.Condition
Clinical Trials
Trial Phases
Allergic Conjunctivitis (AC)
1 Actively Recruiting
Phase 2
Eye
0 Actively Recruiting
Asthma, Allergic
6 Actively Recruiting
Early Phase 1, Not Applicable, Phase 3, Phase 2
Seasonal Allergic Conjunctivitis
0 Actively Recruiting
Zaditor Reviews: What are patients saying about Zaditor?
5Patient Review
4/15/2013 I've had a lot of trouble in the past finding medication that works for my environmental allergies long-term, but Zaditor has been a godsend. It relieved my itchy, burning eyes almost immediately and I didn't have any pressure build-up either.
5Patient Review
1/27/2009 So far, so good! I used it for the first time 3 hours ago and was able to go outside without any problems. I feel a tiny bit scratchy but nothing compared to what it would have been without the treatment. So far one drop has worked well for me.
5Patient Review
2/21/2010 The only issue I have is that sometimes when my eyes are tearing, some of the medication gets diluted and washed away before it can be effective. I'm wondering if a gel might be better than drops in this case.
5Patient Review
4/10/2013 I've tried a lot of brands, even prescriptions, and this is the one that actually worked for me.
5Patient Review
1/2/20084.7Patient Review
9/27/2010 This medication has been a life saver for me; its the only medication that I have taken that has relieved my itchy eyes, which is the least tolerable allergy symptom for me.
4Patient Review
8/19/2010 Zaditor is a great supplement to Patanol, which can be expensive. Zaditor works well, but not as well as Patanol. I've been using Patanol for years and this is my first bottle of Zaditor.
4Patient Review
5/9/2013 This medicine did a good job of reducing my seasonal allergy-related itching, but it came at the cost of drying out my eyes and making them extra sensitive to light. Additionally, I am very sensitive to the side effects of antihistamines, and after several days of use I felt very sleepy all day long.
3.3Patient Review
8/26/2008 This drug didn't really do it for me.
Patient Q&A Section about zaditor
These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.How many times a day can I use Zaditor?
"The recommended dose of Zaditor for adults and children 3 years of age and older is 1 drop in the affected eye(s) twice daily. The medication should be taken every 8-12 hours, no more than twice per day."
Answered by AI
Whats the difference between Pataday and Zaditor?
"If you're looking for an over-the-counter medication to treat itchy eyes caused by allergies, Zaditor (ketotifen) is the first choice. However, it won't work for infections, and it may not be effective for severe allergies. It starts working in less than 30 minutes, and it's safe to use in children aged 2 or older. Another option is Pataday (olopatadine), which is a once-daily formulation."
Answered by AI
What is Zaditor used to treat?
"The medication blocks histamine to prevent and treat itching of the eyes caused by allergies."
Answered by AI
Is Zaditor prescription only?
"Zaditor is now available over-the-counter and does not require a prescription. It is an antihistamine eye drop used to relieve itchy eyes due to allergens. Zaditor is a sterile ophthalmic solution containing ketotifen for topical administration to the eyes."
Answered by AI