Zaditor

Eye, Seasonal Allergic Conjunctivitis, Asthma, Allergic + 1 more

Treatment

4 Active Studies for Zaditor

What is Zaditor

Ketotifen

The Generic name of this drug

Treatment Summary

Ketotifen is a medication used to treat allergies and allergic reactions. It was first developed in 1970 by Sandoz Pharmaceuticals and is now used in the U.S. as an over-the-counter ophthalmic product to relieve itchy eyes caused by allergies. In Canada, it is a prescription-only product prescribed to children with asthma. Oral ketotifen is also available in Mexico and Europe for other allergic symptoms and conditions such as hives, mastocytosis, and food allergies.

Allergy Eye Original Prescription Strength

is the brand name

image of different drug pills on a surface

Zaditor Overview & Background

Brand Name

Generic Name

First FDA Approval

How many FDA approvals?

Allergy Eye Original Prescription Strength

Ketotifen

1995

104

Effectiveness

How Zaditor Affects Patients

Ketotifen is a medication that helps to prevent asthma attacks by blocking the effects of substances that cause inflammation. It takes about 6-12 weeks for this drug to start working. Studies have found that ketotifen can reduce the number, intensity, and duration of asthma attacks, and may allow the use of fewer other medications for the condition.

How Zaditor works in the body

Ketotifen blocks allergic reactions in the body by blocking a type of cell receptor that reacts to histamine. It also helps to stabilize cells that release inflammatory mediators like histamine and leukotrienes, which can cause irritation and inflammation. Additionally, it has been observed that it helps to prevent airway hyperactivity, and stops eosinophils and platelets from accumulating in the airways. It also helps to reduce bronchoconstriction caused by leukotrienes, and suppresses priming of eosinophils.

When to interrupt dosage

The advised dosage of Zaditor is contingent upon the identified condition, including Asthma, Allergic, Allergic Conjunctivitis (AC) and Hay Fever. The measure of dosage fluctuates according to the method of delivery (e.g. Solution or Ophthalmic) featured in the table underneath.

Condition

Dosage

Administration

Eye

, 0.35 mg/mL, 0.25 mg/mL, 0.345 mg/mL, 250.0 mg/mL, 1.0 mg, 0.5 mg/mL, 1.0 mg/mL

, Ophthalmic, Solution, Solution - Ophthalmic, Solution / drops, Solution / drops - Ophthalmic, Syrup, Oral, Tablet - Oral, Syrup - Oral, Tablet, Solution / drops - Oral

Seasonal Allergic Conjunctivitis

, 0.35 mg/mL, 0.25 mg/mL, 0.345 mg/mL, 250.0 mg/mL, 1.0 mg, 0.5 mg/mL, 1.0 mg/mL

, Ophthalmic, Solution, Solution - Ophthalmic, Solution / drops, Solution / drops - Ophthalmic, Syrup, Oral, Tablet - Oral, Syrup - Oral, Tablet, Solution / drops - Oral

Asthma, Allergic

, 0.35 mg/mL, 0.25 mg/mL, 0.345 mg/mL, 250.0 mg/mL, 1.0 mg, 0.5 mg/mL, 1.0 mg/mL

, Ophthalmic, Solution, Solution - Ophthalmic, Solution / drops, Solution / drops - Ophthalmic, Syrup, Oral, Tablet - Oral, Syrup - Oral, Tablet, Solution / drops - Oral

Allergic Conjunctivitis (AC)

, 0.35 mg/mL, 0.25 mg/mL, 0.345 mg/mL, 250.0 mg/mL, 1.0 mg, 0.5 mg/mL, 1.0 mg/mL

, Ophthalmic, Solution, Solution - Ophthalmic, Solution / drops, Solution / drops - Ophthalmic, Syrup, Oral, Tablet - Oral, Syrup - Oral, Tablet, Solution / drops - Oral

Warnings

Zaditor has two contraindications, so it should not be joined with the illnesses indicated in the following table.

Zaditor Contraindications

Condition

Risk Level

Notes

Pulse Frequency

Do Not Combine

Severe Hypersensitivity Reactions

Do Not Combine

Ketotifen may interact with Pulse Frequency

There are 13 known major drug interactions with Zaditor.

Common Zaditor Drug Interactions

Drug Name

Risk Level

Description

Pitolisant

Major

The therapeutic efficacy of Pitolisant can be decreased when used in combination with Ketotifen.

Benzylpenicilloyl polylysine

Moderate

Ketotifen may decrease effectiveness of Benzylpenicilloyl polylysine as a diagnostic agent.

Betahistine

Moderate

The therapeutic efficacy of Betahistine can be decreased when used in combination with Ketotifen.

Deoxyepinephrine

Moderate

The therapeutic efficacy of Deoxyepinephrine can be increased when used in combination with Ketotifen.

Droxidopa

Moderate

The therapeutic efficacy of Droxidopa can be increased when used in combination with Ketotifen.

Zaditor Toxicity & Overdose Risk

Taking too much ketotifen may cause feelings of extreme drowsiness, confusion, fast heartbeat, low blood pressure, seizures, restlessness (especially in children), and unconsciousness. If the overdose occurred recently, a doctor may use stomach pumping or activated charcoal to reduce the amount of ketotifen in the body. Other treatments may include medicines to control seizures, and medicines to reduce the effects of anticholinergics.

image of a doctor in a lab doing drug, clinical research

Zaditor Novel Uses: Which Conditions Have a Clinical Trial Featuring Zaditor?

14 active clinical trials are assessing the potential of Zaditor to provide relief from Seasonal Allergic Conjunctivitis, Hay Fever, Allergic Asthma and other conditions.

Condition

Clinical Trials

Trial Phases

Seasonal Allergic Conjunctivitis

0 Actively Recruiting

Allergic Conjunctivitis (AC)

1 Actively Recruiting

Phase 2

Eye

0 Actively Recruiting

Asthma, Allergic

3 Actively Recruiting

Early Phase 1, Phase 3, Phase 2

Zaditor Reviews: What are patients saying about Zaditor?

5

Patient Review

4/15/2013

Zaditor for Allergic Conjunctivitis

I've had a lot of trouble in the past finding medication that works for my environmental allergies long-term, but Zaditor has been a godsend. It relieved my itchy, burning eyes almost immediately and I didn't have any pressure build-up either.

5

Patient Review

1/27/2009

Zaditor for Allergic Conjunctivitis

So far, so good! I used it for the first time 3 hours ago and was able to go outside without any problems. I feel a tiny bit scratchy but nothing compared to what it would have been without the treatment. So far one drop has worked well for me.

5

Patient Review

2/21/2010

Zaditor for Allergic Conjunctivitis

The only issue I have is that sometimes when my eyes are tearing, some of the medication gets diluted and washed away before it can be effective. I'm wondering if a gel might be better than drops in this case.

5

Patient Review

4/10/2013

Zaditor for Allergic Conjunctivitis

I've tried a lot of brands, even prescriptions, and this is the one that actually worked for me.

5

Patient Review

1/2/2008

Zaditor for Allergic Conjunctivitis

4.7

Patient Review

9/27/2010

Zaditor for Allergic Conjunctivitis

This medication has been a life saver for me; its the only medication that I have taken that has relieved my itchy eyes, which is the least tolerable allergy symptom for me.

4

Patient Review

8/19/2010

Zaditor for Allergic Conjunctivitis

Zaditor is a great supplement to Patanol, which can be expensive. Zaditor works well, but not as well as Patanol. I've been using Patanol for years and this is my first bottle of Zaditor.

4

Patient Review

5/9/2013

Zaditor for Allergic Conjunctivitis

This medicine did a good job of reducing my seasonal allergy-related itching, but it came at the cost of drying out my eyes and making them extra sensitive to light. Additionally, I am very sensitive to the side effects of antihistamines, and after several days of use I felt very sleepy all day long.

3.3

Patient Review

8/26/2008

Zaditor for Allergic Conjunctivitis

This drug didn't really do it for me.
image of drug pills surrounding a glass of water symbolizing drug consumption

Patient Q&A Section about zaditor

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

How many times a day can I use Zaditor?

"The recommended dose of Zaditor for adults and children 3 years of age and older is 1 drop in the affected eye(s) twice daily. The medication should be taken every 8-12 hours, no more than twice per day."

Answered by AI

Whats the difference between Pataday and Zaditor?

"If you're looking for an over-the-counter medication to treat itchy eyes caused by allergies, Zaditor (ketotifen) is the first choice. However, it won't work for infections, and it may not be effective for severe allergies. It starts working in less than 30 minutes, and it's safe to use in children aged 2 or older. Another option is Pataday (olopatadine), which is a once-daily formulation."

Answered by AI

What is Zaditor used to treat?

"The medication blocks histamine to prevent and treat itching of the eyes caused by allergies."

Answered by AI

Is Zaditor prescription only?

"Zaditor is now available over-the-counter and does not require a prescription. It is an antihistamine eye drop used to relieve itchy eyes due to allergens. Zaditor is a sterile ophthalmic solution containing ketotifen for topical administration to the eyes."

Answered by AI

Clinical Trials for Zaditor