Transcranial Electrical Stimulation for Sleep Deprivation
What You Need to Know Before You Apply
What is the purpose of this trial?
This trial explores whether transcranial electrical stimulation (TES), a special type of brain stimulation, can improve sleep quality and performance during sleep deprivation. The treatment aims to increase slow-wave brain activity, believed to enhance sleep's restorative effects. Participants will receive either the actual TES treatment or a sham (fake) version for comparison. The study seeks healthy individuals who typically sleep 6 to 9 hours per night and do not engage in excessive caffeine consumption or regular napping. As an unphased trial, it offers participants the chance to contribute to groundbreaking research on sleep enhancement.
Do I need to stop taking my current medications to join the trial?
The trial protocol does not clearly specify if you need to stop taking your current medications. However, it mentions that the use of products or drugs that cannot be safely discontinued during in-laboratory phases will be determined on a case-by-case basis by the study investigator.
What prior data suggests that transcranial electrical stimulation is safe for sleep deprivation studies?
Research has shown that transcranial electrical stimulation (TES) is generally safe. One study found TES to be safe and effective in improving memory and focus in sleep-deprived individuals, with no major safety concerns reported. Another review examined multiple studies and found that TES could influence brain activity during sleep, though effects varied. In summary, TES has been tested on both healthy individuals and patients, demonstrating safety and potential benefits for sleep and memory.12345
Why are researchers excited about this trial?
Researchers are excited about Transcranial Electrical Stimulation (TES) at Slow Oscillation (SO) Frequency because it offers a novel approach to addressing sleep deprivation, which is typically managed with medications like stimulants or behavioral therapies. Unlike these standard treatments, TES uses a non-invasive technique that directly applies electrical currents to the brain to enhance natural sleep rhythms. This method has the potential to improve cognitive performance and mood without the side effects often associated with traditional medications. Additionally, TES could offer immediate benefits during short sleep periods, which is particularly promising for situations requiring rapid recovery from sleep deprivation.
What evidence suggests that transcranial electrical stimulation is effective for sleep deprivation?
Research has shown that transcranial electrical stimulation (TES) at a slow frequency might enhance brain activity during sleep. One study found that TES increased slow-wave activity in the brain, which is linked to better recovery after sleep deprivation. Another study suggested that TES might aid memory improvement during sleep. Although the overall impact on sleep may be modest, TES shows promise in enhancing specific aspects like sleep quality and mental function. In this trial, some participants will receive TES at a slow oscillation frequency, while others will receive a sham treatment without TES. These findings suggest that TES could make sleep more restorative, especially when sleep is limited.24678
Who Is on the Research Team?
John D. Hughes, CDR, MC, USN
Principal Investigator
Naval Medical Research Center
Are You a Good Fit for This Trial?
This trial is for individuals who understand the study protocol, consume less than 400 mg of caffeine daily, have a normal sleep pattern (6-9 hours), and do not use heavy alcohol or drugs. They must not have cardiovascular disease, habitual napping, psychiatric hospitalizations in the last 2 years, abnormal blood tests, or be pregnant. Smokers and those with neurological disorders are excluded.Inclusion Criteria
Exclusion Criteria
Timeline for a Trial Participant
Screening
Participants are screened for eligibility to participate in the trial
At-home component
Participants complete a 7-day at-home component prior to the in-laboratory study
In-laboratory study period
Participants undergo TES SO or sham stimulation during a 2-hour sleep period followed by 46 hours of sleep deprivation with cognitive and mood assessments
Follow-up
Participants are monitored for safety and effectiveness after treatment
What Are the Treatments Tested in This Trial?
Interventions
- Transcranial Electrical Stimulation (TES) at Slow Oscillation (SO) Frequency
Find a Clinic Near You
Who Is Running the Clinical Trial?
U.S. Army Medical Research and Development Command
Lead Sponsor
Walter Reed Army Institute of Research (WRAIR)
Collaborator