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What is Mirvaso
BrimonidineThe Generic name of this drug
Treatment SummaryBrimonidine is a medication that was approved by the FDA in 1996 to lower eye pressure and treat glaucoma. It is also used to reduce facial redness caused by rosacea. Brimonidine works by targeting the alpha-2 adrenergic receptors in the eyes, which helps to reduce the production of aqueous humor and increase uveoscleral outflow. It is less likely to cause allergic reactions in the eyes compared to other medications in its class. It is not associated with cardiopulmonary side effects like nonselective beta-blockers, making it a safer option for people with or at risk
Alphagan Pis the brand name
Mirvaso Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Alphagan P
Brimonidine
2001
43
Approved as Treatment by the FDA
Brimonidine, commonly known as Alphagan P, is approved by the FDA for 3 uses including Increased Intra Ocular Pressure (IOP) and Open Angle Glaucoma .Increased Intra Ocular Pressure (IOP)
Helps manage Increased Intra Ocular Pressure (IOP)
Open Angle Glaucoma
Helps manage Open Angle Glaucoma (OAG)
Ocular Hypertension
Helps manage Ocular Hypertension
Effectiveness
How Mirvaso Affects PatientsBrimonidine is a drug that helps lower eye pressure and reduce inflammation. It works by targeting certain parts of the body, like the alpha-2 adrenergic receptor, which helps reduce the risk of unwanted side effects such as low blood pressure, slower heart rate, and drowsiness. It also reduces the risk of ocular side effects like red eyes and pupil constriction. After taking brimonidine, the maximum effect is usually seen two hours later with a 23% reduction in eye pressure. Studies have also shown that it can be used to reduce facial redness from rosacea and inflammation from injury. When taken systemically,
How Mirvaso works in the bodyBrimonidine works by activating alpha-2 adrenoceptors found in the eye. This causes a decrease in the production of aqueous humor, a fluid that can increase pressure within the eye. By reducing this pressure, brimonidine helps to prevent and slow the progression of vision loss caused by glaucoma. It can also be used topically on skin to reduce redness, as it causes vasoconstriction of the small arteries and veins.
When to interrupt dosage
The suggested dosage of Mirvaso is contingent upon the diagnosed condition, such as Open Angle Glaucoma, facial erythema and Ocular Hypertension. The amount of dosage is subject to the method of delivery outlined in the table down below.Condition
Dosage
Administration
Open-angle glaucoma
, 1.5 mg/mL, 1.0 mg/mL, 2.0 mg/mL, 2.0 mg/mg, 0.2 %, 0.15 %, 0.33 %, 0.003 mg/mg, 0.005 mg/mg, 0.25 mg/mL, 0.0025 mg/mg, 0.025 %
, Ophthalmic, Solution / drops, Solution / drops - Ophthalmic, Suspension / drops, Suspension / drops - Ophthalmic, Solution, Solution - Ophthalmic, Liquid, Liquid - Ophthalmic, Topical, Gel, Gel - Topical, Cutaneous, Gel - Cutaneous, Suspension - Ophthalmic, Suspension
Rosacea
, 1.5 mg/mL, 1.0 mg/mL, 2.0 mg/mL, 2.0 mg/mg, 0.2 %, 0.15 %, 0.33 %, 0.003 mg/mg, 0.005 mg/mg, 0.25 mg/mL, 0.0025 mg/mg, 0.025 %
, Ophthalmic, Solution / drops, Solution / drops - Ophthalmic, Suspension / drops, Suspension / drops - Ophthalmic, Solution, Solution - Ophthalmic, Liquid, Liquid - Ophthalmic, Topical, Gel, Gel - Topical, Cutaneous, Gel - Cutaneous, Suspension - Ophthalmic, Suspension
Open Angle Glaucoma
, 1.5 mg/mL, 1.0 mg/mL, 2.0 mg/mL, 2.0 mg/mg, 0.2 %, 0.15 %, 0.33 %, 0.003 mg/mg, 0.005 mg/mg, 0.25 mg/mL, 0.0025 mg/mg, 0.025 %
, Ophthalmic, Solution / drops, Solution / drops - Ophthalmic, Suspension / drops, Suspension / drops - Ophthalmic, Solution, Solution - Ophthalmic, Liquid, Liquid - Ophthalmic, Topical, Gel, Gel - Topical, Cutaneous, Gel - Cutaneous, Suspension - Ophthalmic, Suspension
Ocular Hypertension
, 1.5 mg/mL, 1.0 mg/mL, 2.0 mg/mL, 2.0 mg/mg, 0.2 %, 0.15 %, 0.33 %, 0.003 mg/mg, 0.005 mg/mg, 0.25 mg/mL, 0.0025 mg/mg, 0.025 %
, Ophthalmic, Solution / drops, Solution / drops - Ophthalmic, Suspension / drops, Suspension / drops - Ophthalmic, Solution, Solution - Ophthalmic, Liquid, Liquid - Ophthalmic, Topical, Gel, Gel - Topical, Cutaneous, Gel - Cutaneous, Suspension - Ophthalmic, Suspension
facial erythema
, 1.5 mg/mL, 1.0 mg/mL, 2.0 mg/mL, 2.0 mg/mg, 0.2 %, 0.15 %, 0.33 %, 0.003 mg/mg, 0.005 mg/mg, 0.25 mg/mL, 0.0025 mg/mg, 0.025 %
, Ophthalmic, Solution / drops, Solution / drops - Ophthalmic, Suspension / drops, Suspension / drops - Ophthalmic, Solution, Solution - Ophthalmic, Liquid, Liquid - Ophthalmic, Topical, Gel, Gel - Topical, Cutaneous, Gel - Cutaneous, Suspension - Ophthalmic, Suspension
inadequately controlled intraocular pressure
, 1.5 mg/mL, 1.0 mg/mL, 2.0 mg/mL, 2.0 mg/mg, 0.2 %, 0.15 %, 0.33 %, 0.003 mg/mg, 0.005 mg/mg, 0.25 mg/mL, 0.0025 mg/mg, 0.025 %
, Ophthalmic, Solution / drops, Solution / drops - Ophthalmic, Suspension / drops, Suspension / drops - Ophthalmic, Solution, Solution - Ophthalmic, Liquid, Liquid - Ophthalmic, Topical, Gel, Gel - Topical, Cutaneous, Gel - Cutaneous, Suspension - Ophthalmic, Suspension
Increased Intra Ocular Pressure (IOP)
, 1.5 mg/mL, 1.0 mg/mL, 2.0 mg/mL, 2.0 mg/mg, 0.2 %, 0.15 %, 0.33 %, 0.003 mg/mg, 0.005 mg/mg, 0.25 mg/mL, 0.0025 mg/mg, 0.025 %
, Ophthalmic, Solution / drops, Solution / drops - Ophthalmic, Suspension / drops, Suspension / drops - Ophthalmic, Solution, Solution - Ophthalmic, Liquid, Liquid - Ophthalmic, Topical, Gel, Gel - Topical, Cutaneous, Gel - Cutaneous, Suspension - Ophthalmic, Suspension
Warnings
Mirvaso ContraindicationsCondition
Risk Level
Notes
Pulse Frequency
Do Not Combine
Pulse Frequency
Do Not Combine
Severe Hypersensitivity Reactions
Do Not Combine
Brimonidine may interact with Pulse Frequency
Common Mirvaso Drug Interactions
Drug Name
Risk Level
Description
Oliceridine
Major
The risk or severity of hypotension, sedation, death, somnolence, and respiratory depression can be increased when Brimonidine is combined with Oliceridine.
Acebutolol
Minor
Brimonidine may increase the antihypertensive activities of Acebutolol.
Aliskiren
Minor
Brimonidine may increase the antihypertensive activities of Aliskiren.
Alprenolol
Minor
Brimonidine may increase the antihypertensive activities of Alprenolol.
Ambrisentan
Minor
Brimonidine may increase the antihypertensive activities of Ambrisentan.
Mirvaso Toxicity & Overdose RiskThe toxic dose of brimonidine in mice is 50 mg/kg and 100 mg/kg in rats. If a person takes too much brimonidine, they may experience low blood pressure, weakness, vomiting, drowsiness, slow heart rate, abnormal heart rhythm, constricted pupils, difficulty breathing, reduced body temperature, and seizures. Treatment for an overdose includes supportive care. Studies have found that brimonidine is not linked to birth defects when taken during pregnancy, and no effects on fertility have been seen so far. However, it is not recommended for pregnant or breastfeeding women, infants under 2 years old, or
Mirvaso Novel Uses: Which Conditions Have a Clinical Trial Featuring Mirvaso?
114 active clinical trials are currently being conducted to assess the potential of Mirvaso to reduce inadequately controlled intraocular pressure and Open Angle Glaucoma.Condition
Clinical Trials
Trial Phases
Open-angle glaucoma
84 Actively Recruiting
Phase 3, Not Applicable, Phase 1, Phase 2, Phase 4, Early Phase 1
Rosacea
0 Actively Recruiting
Ocular Hypertension
22 Actively Recruiting
Phase 1, Phase 2, Not Applicable, Phase 3, Phase 4
Open Angle Glaucoma
12 Actively Recruiting
Not Applicable, Phase 3, Phase 2
inadequately controlled intraocular pressure
0 Actively Recruiting
facial erythema
0 Actively Recruiting
Increased Intra Ocular Pressure (IOP)
0 Actively Recruiting
Mirvaso Reviews: What are patients saying about Mirvaso?
5Patient Review
5/21/2018 I found that Mirvaso worked much better for me when I mixed it with an over-the-counter hydrocortisone cream.
5Patient Review
1/7/2019 Mirvaso has really helped me when I need to get rid of redness quickly. A little goes a long way with this product, and it's definitely worth the price tag.
5Patient Review
11/9/2018 I've been using this for a while now, and it's helped me a lot. I take it every morning and it's just become part of my routine.
5Patient Review
8/23/2022 I've been using Mirvaso for a while now and it's the only medication that has reliably helped reduce the redness on my face.
5Patient Review
4/28/2017 This is the only treatment that has been effective in reducing the redness on my skin.
5Patient Review
5/23/2017 Mirvaso is an effective treatment for me. I've been using it on and off for a few years now.
5Patient Review
8/17/2017 Mirvaso was very effective for me, though it took some experimentation to get the dosage and application right.
3Patient Review
5/25/2016 I used this product for about a week with little flushing that I initially thought was just the rosacea. However, I then had the worst rebound flushing of my life. My cheeks were red and purple, and I felt like I was on fire! It took about a week to subside.
2.3Patient Review
9/28/2016 I had great results for the first week, but then on days 10 and 11 I started to experience adverse reactions. My skin would become hot, tingly, and flushed after only 5 hours of use. It's been incredibly uncomfortable, and I'm glad I didn't spend any money on this product since it was only a sample size.
2.3Patient Review
6/16/2022 Worked well for the first two days, but then I had a really bad reaction on the third morning. My face was burning and bright red. Avoid this product.
1.7Patient Review
4/8/2022 I was initially excited for this treatment, but then started experiencing some very unpleasant side effects. My face is now constantly flared up and boiling, and it's even effecting areas that weren't noticeable before! I'm hoping these side effects will go away soon.
1Patient Review
10/18/2020 I had a mild case of rosacea with redness on my nose and cheeks. Today, on the third day of using Mirvaso, I woke up to find that everywhere I applied the gel now had red bumps and my face was even more red than before. Needless to say, I won't be continuing use of this product.
Patient Q&A Section about mirvaso
These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.Can I buy Mirvaso gel over the counter?
"Can I buy Mirvaso (brimonidine) without a prescription?
No, the medication is available by prescription only. If you're looking for over-the-counter treatments for rosacea, Prosacea gel may help with redness, but talk to your provider first to see if it is the right treatment for you."
Answered by AI
How effective is Mirvaso for rosacea?
"Facial redness caused by rosacea can be significantly reduced by using MIRVASO® (brimonidine) topical gel, 0.33%. In clinical trials, subjects who used the gel saw their redness diminished for up to 12 hours. For many, the redness began to fade fast—often in as little as 30 minutes. However, results can vary from person to person."
Answered by AI
What does Mirvaso do?
"Brimonidine is a medication used to treat rosacea, a skin disorder. It works by narrowing blood vessels to reduce redness. Brimonidine belongs to a class of drugs known as alpha agonists."
Answered by AI
How long should you use Mirvaso?
"Begin treatment with a small amount of gel and slowly increase the amount based on how the patient tolerates it and how they respond to the gel. There is limited experience with Mirvaso in patients over 65 years old."
Answered by AI