Multidomain Exercise & Cognitive Training for Aging-related Cognitive Decline
(ACTIONcR Trial)
Trial Summary
What is the purpose of this trial?
The ACTIONcardioRisk trial is designed to investigate the effect of aerobic and progressive resistance training exercises combined with cognitive training, on neurocognitive functioning of sedentary older adults with and without cardiovascular risk factors.
Do I need to stop taking my current medications for the trial?
The trial information does not specify whether you need to stop taking your current medications. It's best to discuss this with the trial coordinators or your doctor.
What data supports the effectiveness of this treatment for aging-related cognitive decline?
Research shows that combining physical exercise and cognitive training can help maintain and improve cognitive functions in older adults. Studies indicate that this combined approach can enhance executive functions, balance, and overall cognitive health, making it a promising non-drug option for addressing cognitive decline in aging individuals.12345
Is the multidomain exercise and cognitive training generally safe for humans?
How does the Multidomain Exercise & Cognitive Training treatment differ from other treatments for aging-related cognitive decline?
This treatment is unique because it combines aerobic and resistance exercises with cognitive training, which may provide additive benefits for cognitive function and physical balance compared to single interventions. It targets both physical and cognitive aspects simultaneously, potentially offering broader improvements in executive functions and overall cognition.456710
Research Team
Louis Bherer, PhD
Principal Investigator
Montreal Heart Institute
Eligibility Criteria
This trial is for sedentary adults aged 60 and older who are generally healthy, with no cognitive impairment (scoring at least 25 on the MMSE), and have normal vision and hearing for their age. It's not suitable for those with severe cardiovascular or respiratory diseases, excessive alcohol consumption, certain heart conditions, uncontrolled mental health issues within the past six months, neurological diseases or dementia.Inclusion Criteria
Exclusion Criteria
Timeline
Screening
Participants are screened for eligibility to participate in the trial
Treatment
Participants undergo aerobic and resistance training, with or without cognitive training, three sessions per week for 46 weeks
Follow-up
Participants are monitored for changes in cognitive functioning and other health metrics post-intervention
Treatment Details
Interventions
- Aerobic and resistance exercises
- Cognitive Training
- Stretching and Toning
Aerobic and resistance exercises is already approved in Canada for the following indications:
- Prevention of cognitive decline in older adults with mild cognitive impairment
Find a Clinic Near You
Who Is Running the Clinical Trial?
Louis Bherer
Lead Sponsor
Canadian Institutes of Health Research (CIHR)
Collaborator
The Montreal Health Innovations Coordinating Center (MHICC)
Collaborator