Twin Block with Local Anesthetic for Acute Pain

Phase-Based Progress Estimates
1
Effectiveness
2
Safety
Acute Pain
Twin block local anesthetic nerve block using standard dental anesthetic - Drug
Eligibility
18+
All Sexes
What conditions do you have?
Select

Study Summary

This trial is testing whether using a twin block injection to numb the 'jaw-clencher' muscles can reduce pain and the need for opioids following wisdom tooth removal.

Treatment Effectiveness

Study Objectives

3 Primary · 1 Secondary · Reporting Duration: one week

15 minutes
Post-injection muscle pain
one week
Mean NRS pain score
Passive mouth opening
Total prescription opioid consumption

Trial Safety

Safety Progress

2 of 3
This is further along than 68% of similar trials

Trial Design

2 Treatment Groups

Twin Block with Local Anesthetic
1 of 2
Twin Block with sterile normal saline
1 of 2

Active Control

Non-Treatment Group

48 Total Participants · 2 Treatment Groups

Primary Treatment: Twin Block with Local Anesthetic · Has Placebo Group · Phase 2

Twin Block with sterile normal saline
Other
PlaceboComparator Group · 1 Intervention: Twin block with placebo · Intervention Types: Other
Twin Block with Local Anesthetic
Drug
ActiveComparator Group · 1 Intervention: Twin block local anesthetic nerve block using standard dental anesthetic · Intervention Types: Drug

Trial Logistics

Trial Timeline

Screening: ~3 weeks
Treatment: Varies
Reporting: one week

Who is running the clinical trial?

Rutgers, The State University of New JerseyLead Sponsor
369 Previous Clinical Trials
60,617 Total Patients Enrolled
2 Trials studying Acute Pain
116 Patients Enrolled for Acute Pain
New Jersey Health FoundationUNKNOWN
1 Previous Clinical Trials
107 Total Patients Enrolled
Gayathri Subramanian, PhD, DMDPrincipal InvestigatorRutgers School of Dental Medicine, Newark NJ

Eligibility Criteria

Age 18+ · All Participants · 7 Total Inclusion Criteria

Mark “Yes” if the following statements are true for you:
If you are over the age of 18, you have given informed consent.
You are willing to participate in the study and not be excluded by the following criteria below.
You have no cognitive/intellectual disability.
You have an electronic device with internet connection.\n

About The Reviewer

Michael Gill preview

Michael Gill - B. Sc.

First Published: October 9th, 2021

Last Reviewed: November 24th, 2022

Michael Gill holds a Bachelors of Science in Integrated Science and Mathematics from McMaster University. During his degree he devoted considerable time modeling the pharmacodynamics of promising drug candidates. Since then, he has leveraged this knowledge of the investigational new drug ecosystem to help his father navigate clinical trials for multiple myeloma, an experience which prompted him to co-found Power Life Sciences: a company that helps patients access randomized controlled trials.

References