Twin Block with Local Anesthetic for Acute Pain
Study Summary
This trial is testing whether using a twin block injection to numb the 'jaw-clencher' muscles can reduce pain and the need for opioids following wisdom tooth removal.
Treatment Effectiveness
Effectiveness Progress
Study Objectives
3 Primary · 1 Secondary · Reporting Duration: one week
Trial Safety
Safety Progress
Trial Design
2 Treatment Groups
Twin Block with Local Anesthetic
1 of 2
Twin Block with sterile normal saline
1 of 2
Active Control
Non-Treatment Group
48 Total Participants · 2 Treatment Groups
Primary Treatment: Twin Block with Local Anesthetic · Has Placebo Group · Phase 2
Trial Logistics
Trial Timeline
Who is running the clinical trial?
Eligibility Criteria
Age 18+ · All Participants · 7 Total Inclusion Criteria
Mark “Yes” if the following statements are true for you:About The Reviewer
Michael Gill - B. Sc.
First Published: October 9th, 2021
Last Reviewed: November 24th, 2022
Michael Gill holds a Bachelors of Science in Integrated Science and Mathematics from McMaster University. During his degree he devoted considerable time modeling the pharmacodynamics of promising drug candidates. Since then, he has leveraged this knowledge of the investigational new drug ecosystem to help his father navigate clinical trials for multiple myeloma, an experience which prompted him to co-found Power Life Sciences: a company that helps patients access randomized controlled trials.
- “Efficacy of the Twin Block, a Peripheral Nerve Block for the Management of Chronic Masticatory Myofascial Pain: A Case Series”. 2017. “Efficacy of the Twin Block, a Peripheral Nerve Block for the Management of Chronic Masticatory Myofascial Pain: A Case Series”. JB. Quintessence International 48 (10). DE: Quintessenz Verlags-GmbH: 829–33. doi:10.3290/j.qi.a39094.
- Quek, Samuel Y. P., Julyana Gomes-Zagury, and Gayathri Subramanian. 2020. “Twin Block in Myogenous Orofacial Pain: Applied Anatomy, Technique Update, and Safety”. Anesthesia Progress. American Dental Society of Anesthesiology (ADSA). doi:10.2344/anpr-67-01-03.
- Quek, Samuel, Andrew Young, and Gayathri Subramanian. 2014. “The Twin Block: A Simple Technique to Block Both the Masseteric and the Anterior Deep Temporal Nerves with One Anesthetic Injection”. Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology. Elsevier BV. doi:10.1016/j.oooo.2014.01.227.
- Quek SYP, Gomes-Zagury J, Subramanian G. Twin Block in Myogenous Orofacial Pain: Applied Anatomy, Technique Update, and Safety. Anesth Prog. 2020 Jun 1;67(2):103-106. doi: 10.2344/anpr-67-01-03.
- Kanti V, Ananthan S, Subramanian G, Quek SYP. Efficacy of the twin block, a peripheral nerve block for the management of chronic masticatory myofascial pain: A case series. Quintessence Int. 2017 Oct 6:725-729. doi: 10.3290/j.qi.a39094. Online ahead of print.
- Gayathri Subramanian, PhD, DMD 2022. "Twin Block, Pain Medications and Third Molar Extractions". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT04880707.