Genetic Testing for Alcohol Flushing

(AIAC Trial)

Age: 18+

Sex: Any

Trial Phase: Academic

Sponsor: Stanford University

Compensation: Varies

Number of Visits: 2

100 Participants Needed

Trial Summary

What is the purpose of this trial?

The overall aim of the study is to raise awareness of alcohol flushing and its health risks to the general population. The primary objective is to see if spreading awareness of the health risks of alcohol flushing and understanding personalized genotype information will lead to changes in alcohol consumption behavior.

Do I need to stop my current medications for this trial?

The trial information does not specify whether you need to stop taking your current medications.

What data supports the effectiveness of ALDH2 Genotyping treatment for alcohol flushing?

Research shows that people with certain ALDH2 genotypes experience more intense flushing after drinking alcohol, which suggests that ALDH2 genotyping can help predict who might have these reactions. This information can be useful in understanding and managing alcohol flushing symptoms. ^{1 2 3 4 5}

Is genetic testing for alcohol flushing safe for humans?

The research articles do not provide specific safety data for genetic testing related to alcohol flushing, but they focus on the accuracy of predicting alcohol sensitivity through genetic testing and other methods. ^{1 2 3 5 6}

How does genetic testing for alcohol flushing differ from other treatments?

Genetic testing for alcohol flushing is unique because it identifies specific genetic variations in the ADH1B and ALDH2 genes that affect how the body processes alcohol, which can lead to flushing. Unlike other treatments that might address symptoms, this approach helps understand the underlying genetic cause of alcohol sensitivity. ^{6 7 8 9 10}

Research Team

Kevin Chang, MD

Principal Investigator

Stanford University

Eligibility Criteria

This trial is open to adults over the age of 18 who are native English speakers. There are no specific exclusion criteria, so it's quite inclusive for those interested in learning about alcohol flushing and its health risks.

Inclusion Criteria

Native English speaker

I am over 18 years old.

Exclusion Criteria

Not applicable.

Timeline

Screening

Participants are screened for eligibility to participate in the trial

2-4 weeks

Education and Awareness

Participants receive education on alcohol flushing and its health risks, and some are informed of their genotype results

3 months

Baseline, 1 month, 3 month

Follow-up

Participants are monitored for changes in alcohol consumption behavior and awareness of alcohol flushing

3 months

1 month, 3 month

Treatment Details

Interventions

• ALDH2 Genotyping

Trial Overview The study focuses on whether educating people about the dangers of alcohol flushing and providing them with their personal ALDH2 genotype information can influence their drinking habits.

Participant Groups

Group I: Genotype Revealed Experimental Treatment 1 Intervention

Subjects with ALDH2 mutation will be notified of positive genotype results after testing completed.

Group II: Gentoype Not-Revealed Placebo Group 1 Intervention

Subjects with ALDH2 mutation will not be notified of positive genotype results until after study completed.

Who Is Running the Clinical Trial?

Stanford University

Lead Sponsor

Trials

2,527

Recruited

17,430,000+

Stanford Center for Asian Health Research and Education

Collaborator

Trials

1

Recruited

100+

References

1. United States pubmed.ncbi.nlm.nih.gov

Alcohol and aldehyde dehydrogenase polymorphisms and alcoholism. [2022]

2. Brazil pubmed.ncbi.nlm.nih.gov

Alcohol flushing, patch test, and ADH and ALDH genotypes in Brazilian ethnic groups. [2021]

3. Japan pubmed.ncbi.nlm.nih.gov

Evaluation of the use of self-reported facial flushing and ethanol patch test for ALDH2 genotypes. [2022]

4. England pubmed.ncbi.nlm.nih.gov

Development of a questionnaire method to discriminate between typical and atypical genotypes of low Km aldehyde dehydrogenase in a Japanese population. [2022]

5. United States pubmed.ncbi.nlm.nih.gov

Investigator-observed alcohol-induced flushing but not self-report of flushing is a valid predictor of ALDH2 genotype. [2021]

6. Japan pubmed.ncbi.nlm.nih.gov

Analysis of aldehyde dehydrogenase 2 gene polymorphism and ethanol patch test as a screening method for alcohol sensitivity. [2019]

7. Germany pubmed.ncbi.nlm.nih.gov

Simple and rapid determination of the acetaldehyde dehydrogenase (ALDH2) genotypes by nonradioactive single-strand conformation polymorphism analysis. [2013]

8. England pubmed.ncbi.nlm.nih.gov

Blood ethanol levels of nonabstinent Japanese alcoholic men in the morning after drinking and their ADH1B and ALDH2 genotypes. [2022]

9. Germany pubmed.ncbi.nlm.nih.gov

Rapid, accurate genotyping of alcohol dehydrogenase-1B and aldehyde dehydrogenase-2 based on the use of denaturing HPLC. [2016]

10. Switzerland pubmed.ncbi.nlm.nih.gov

Duplex PCR-RFLP for the Simultaneous Genotyping of Single Nucleotide Polymorphisms in ADH1B and ALDH2 Genes. [2018]