Vestibular Therapy for Alzheimer's Disease
Trial Summary
Will I have to stop taking my current medications?
If you are taking daily vestibular suppressant medications like anti-histamines or benzodiazepines, you will need to stop them to participate in the trial.
What data supports the effectiveness of the treatment Vestibular Therapy for Alzheimer's Disease?
Research suggests that vestibular therapy can improve balance and reduce the risk of falls in people with Alzheimer's disease, as it is effective in addressing vestibular impairments, which are common in these patients. Although not specifically tested in Alzheimer's patients, similar therapies have shown benefits in improving balance in individuals with cognitive impairments.12345
Is vestibular therapy safe for people with Alzheimer's disease?
How is vestibular therapy different from other treatments for Alzheimer's disease?
Vestibular therapy is unique for Alzheimer's patients because it focuses on improving balance and reducing fall risk by addressing vestibular (inner ear balance) impairments, which are common in these patients but often overlooked. Unlike other treatments that may not target balance issues directly, this therapy uses specialized exercises to enhance vestibular function and motor learning, potentially reducing falls and improving quality of life.12346
What is the purpose of this trial?
Nearly 2 out of 3 patients with Alzheimer's disease (AD) experience problems with balance and mobility, which places such patients at increased risk of falling. The vestibular (inner ear balance) system plays an important role in balance stability, and vestibular therapy (VT) is well-known to improve balance function in healthy older adults. In this study, the investigators will conduct a first-in-kind randomized clinical trial to evaluate whether vestibular therapy improves reduces falls in patients with AD, in whom this treatment has never been studied.
Research Team
Yuri Agrawal, MD
Principal Investigator
Johns Hopkins University
Eligibility Criteria
This trial is for people over 60 with mild-to-moderate Alzheimer's who have balance issues due to inner ear problems. They need a caregiver available and must be able to do certain tests and therapy sessions. Those with severe Alzheimer's, other dementias, or conditions that limit participation (like needing a cane) can't join.Inclusion Criteria
Exclusion Criteria
Timeline
Screening
Participants are screened for eligibility to participate in the trial
Treatment
Participants receive an 8-week course of vestibular therapy or active control exercises
Follow-up
Participants are monitored for incidence of falls over a 1-year period
Treatment Details
Interventions
- Active control
- Vestibular physical therapy
Find a Clinic Near You
Who Is Running the Clinical Trial?
Johns Hopkins University
Lead Sponsor
National Institute on Aging (NIA)
Collaborator