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Engage Therapy for Late-Life Depression with Executive Dysfunction

N/A
Recruiting
Research Sponsored by University of Nevada, Las Vegas
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Clinically significant symptoms of depression as evidenced by Scores > 5 on the Geriatric Depression Scale-Short Form (GDS-SF)
Age 60 or older
Timeline
Screening 3 weeks
Treatment Varies
Follow Up assessed at baseline, week 6, week 9, and week 36 follow-up.
Awards & highlights

Study Summary

This trial is testing a new mental health treatment called "Engage" to see if it's effective in treating depression in older adults with cognitive decline.

Who is the study for?
This trial is for English-speaking adults aged 60 or older in the Las Vegas area with mild cognitive impairment and depression, who can travel to UNLV campus. They should score between 18-25 on MoCA and over 5 on GDS-SF without active suicidal thoughts, history of suicide attempts, psychosis, substance abuse disorders, bipolar disorder, intellectual disability or being in psychotherapy.Check my eligibility
What is being tested?
The Engage program is being tested as a feasible treatment for late-life depression among older adults with cognitive decline. The study aims to confirm if Engage can be an effective therapy option despite the challenges posed by cognitive impairments in this demographic.See study design
What are the potential side effects?
Since Engage is a behavioral therapy approach rather than medication-based treatment, it may not have typical drug side effects. However, participants might experience emotional discomfort or fatigue related to discussing personal issues during sessions.

Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below
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I have significant depression symptoms, scoring over 5 on the GDS-SF.
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I am 60 years old or older.

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~assessed at baseline, week 6, week 9, and week 36 follow-up.
This trial's timeline: 3 weeks for screening, Varies for treatment, and assessed at baseline, week 6, week 9, and week 36 follow-up. for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Hamilton Depression Rating Scale
Secondary outcome measures
Behavioral Activation for Depression Scale (BADS)
Social Problem-Solving Inventory Revised-Short Form
World Health Organization Disability Assessment Schedule 2.0 (WHODAS 2.0)
Other outcome measures
Hopkins Verbal Learning Memory Test-Revised
Iowa Gambling Task - 2nd Edition
Stroop Color-Word Interference Test
+1 more

Trial Design

1Treatment groups
Experimental Treatment
Group I: Engage TreatmentExperimental Treatment1 Intervention
The study is a single-arm study. The single-arm will be implementation of the 9-week protocol of Engage in an older adult population with late-life depression and comorbid executive dysfunction and mild cognitive impairment.
Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
Engage
2019
N/A
~1350

Find a Location

Who is running the clinical trial?

University of Nevada, Las VegasLead Sponsor
66 Previous Clinical Trials
13,769 Total Patients Enrolled

Media Library

Engage Clinical Trial Eligibility Overview. Trial Name: NCT05356611 — N/A
Engage 2023 Treatment Timeline for Medical Study. Trial Name: NCT05356611 — N/A

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Are participants currently being enrolled in this experiment?

"According to clinicaltrials.gov, this trial is no longer recruiting new patients; the original posting on June 1st 2022 was last updated April 26th 2022. However, there are 1861 other trials that remain actively enrolling participants at this time."

Answered by AI

Who else is applying?

What state do they live in?
Pennsylvania
What portion of applicants met pre-screening criteria?
Did not meet criteria
How many prior treatments have patients received?
2

Why did patients apply to this trial?

I have heard that MCI can lead into Alzheimer's disease and I want to stop this before it turns into Alzheimers.
PatientReceived 2+ prior treatments
Recent research and studies
clinicaltrials.govStudy
Engage for Late-Life Depression and Comorbid Executive Dysfunction
Brenna Renn 2023. "Engage for Late-Life Depression and Comorbid Executive Dysfunction". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT05356611.
All > Depression Las Vegas
~3 spots leftby Jun 2024
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