Infliximab for Aneurysms
Trial Summary
Will I have to stop taking my current medications?
The trial requires that you have not used an anti-TNF or other biologic medication in the past 12 months. Other medications are not specifically mentioned, so it's best to discuss your current medications with the trial team.
What data supports the effectiveness of the drug infliximab for treating aneurysms?
Infliximab has shown effectiveness in treating conditions like Crohn's disease and rheumatoid arthritis by reducing symptoms and slowing disease progression. It has also been used in patients with Takayasu arteritis, a condition affecting blood vessels, which may suggest potential benefits for vascular-related issues like aneurysms.12345
Is infliximab generally safe for humans?
Infliximab has been studied for conditions like Crohn's disease and rheumatoid arthritis, showing an acceptable safety profile. Common side effects include infusion reactions like headache and fever, and a higher rate of infections, but no increased risk of serious infections or death. Some rare neurological side effects have been reported, and a small percentage of patients may develop mild autoantibodies, which usually resolve after stopping the drug.678910
How does the drug infliximab differ from other treatments for aneurysms?
Infliximab is unique because it is a monoclonal antibody that targets and neutralizes tumor necrosis factor-alpha (TNF-alpha), a protein involved in inflammation, which may play a role in aneurysm development. Unlike conventional treatments, infliximab offers a targeted approach by specifically addressing the inflammatory component of the disease.211121314
What is the purpose of this trial?
Patients harboring dolichoectactic vertebrobasilar (DVB) aneurysms are at risk of suffering SAH, ischemic stroke, and/or brainstem compression and many patients are not offered invasive treatment due to the futility of existing surgical methods. Consequently, there is demand for development of medical therapy for DVB aneurysms
Research Team
Daniel L Cooke, MD
Principal Investigator
University of California, San Francisco
Eligibility Criteria
This trial is for adults over 18 with a specific type of aneurysm in the brain's arteries that can't be treated with surgery or other common methods. Participants must not have severe kidney issues, recent drug abuse, certain infections like HIV or TB, or liver problems. Women who could get pregnant must use effective contraception and not be breastfeeding.Inclusion Criteria
Exclusion Criteria
Timeline
Screening
Participants are screened for eligibility to participate in the trial
Treatment
Participants receive infliximab intravenously at specified intervals for a total of 12 months
Follow-up
Participants are monitored for safety and effectiveness after treatment
Treatment Details
Interventions
- Infliximab
Infliximab is already approved in European Union, United States, Canada, Japan for the following indications:
- Ankylosing Spondylitis
- Crohn's Disease
- Ulcerative Colitis
- Psoriatic Arthritis
- Rheumatoid Arthritis
- Plaque Psoriasis
- Ankylosing Spondylitis
- Crohn's Disease
- Ulcerative Colitis
- Psoriatic Arthritis
- Rheumatoid Arthritis
- Plaque Psoriasis
- Ankylosing Spondylitis
- Crohn's Disease
- Ulcerative Colitis
- Psoriatic Arthritis
- Rheumatoid Arthritis
- Plaque Psoriasis
- Ankylosing Spondylitis
- Crohn's Disease
- Ulcerative Colitis
- Psoriatic Arthritis
- Rheumatoid Arthritis
- Plaque Psoriasis
Find a Clinic Near You
Who Is Running the Clinical Trial?
University of California, San Francisco
Lead Sponsor