EUS-guided gastrojejunostomy for Gastric Outlet Obstruction

Phase-Based Progress Estimates
1
Effectiveness
1
Safety
Orlando Health, Orlando, FL
Gastric Outlet Obstruction+1 More
Surgical gastrojejunostomy - Procedure
Eligibility
18+
All Sexes
What conditions do you have?
Select

Study Summary

Malignant gastric outlet obstruction (GOO) results from the mechanical obstruction of the duodenum or distal stomach from an underlying cancer. The consequences of GOO are abdominal pain, nausea, vomiting, anorexia, inability to maintain an oral diet and weight loss, with associated poor quality of life and inability to continue with cancer therapy. The aim of this study is to compare the clinical outcomes between surgical gastrojejunostomy and EUS-guided gastrojejunostomy in patients with malignant gastric outlet obstruction.

Eligible Conditions

  • Gastric Outlet Obstruction

Treatment Effectiveness

Effectiveness Progress

1 of 3

Other trials for Gastric Outlet Obstruction

Study Objectives

1 Primary · 13 Secondary · Reporting Duration: 6 months

1 month
Rate of clinical success
Time to diet advancement
24 hours
Procedure duration
Rate of technical success
3 days
Ability to tolerate a soft solid diet at 3 days post-procedure
6 months
Length of survival
Overall treatment costs from index procedure until 6 months post-index procedure.
Quality of life measurement
Rate of adverse events due to underlying disease or procedures performed
Rate of persistence of symptoms
Rate of reintervention
Time to recurrence of obstructive symptoms
Total length of hospital stay
Total number of readmissions

Trial Safety

Safety Progress

1 of 3

Other trials for Gastric Outlet Obstruction

Trial Design

2 Treatment Groups

EUS-guided gastrojejunostomy
1 of 2
Surgical gastrojejunostomy
1 of 2
Active Control

24 Total Participants · 2 Treatment Groups

Primary Treatment: EUS-guided gastrojejunostomy · No Placebo Group · N/A

EUS-guided gastrojejunostomy
Procedure
ActiveComparator Group · 1 Intervention: EUS-guided gastrojejunostomy · Intervention Types: Procedure
Surgical gastrojejunostomy
Procedure
ActiveComparator Group · 1 Intervention: Surgical gastrojejunostomy · Intervention Types: Procedure

Trial Logistics

Trial Timeline

Approximate Timeline
Screening: ~3 weeks
Treatment: Varies
Reporting: 6 months
Closest Location: Orlando Health · Orlando, FL
Photo of Orlando 1Photo of Orlando 2Photo of Orlando 3
2013First Recorded Clinical Trial
1 TrialsResearching Gastric Outlet Obstruction
33 CompletedClinical Trials

Who is running the clinical trial?

Orlando Health, Inc.Lead Sponsor
21 Previous Clinical Trials
10,789 Total Patients Enrolled
Ji Young Bang, MD MPHPrincipal InvestigatorOrlando Health
2 Previous Clinical Trials
110 Total Patients Enrolled

Eligibility Criteria

Age 18+ · All Participants · 3 Total Inclusion Criteria

Mark “yes” if the following statements are true for you:
Presence of gastric outlet obstruction on any imaging or endoscopy from known or suspected malignancy.
You have a gastric outlet obstruction.

About The Reviewer

Michael Gill preview

Michael Gill - B. Sc.

First Published: October 9th, 2021

Last Reviewed: August 12th, 2022

Michael Gill holds a Bachelors of Science in Integrated Science and Mathematics from McMaster University. During his degree he devoted considerable time modeling the pharmacodynamics of promising drug candidates. Since then, he has leveraged this knowledge of the investigational new drug ecosystem to help his father navigate clinical trials for multiple myeloma, an experience which prompted him to co-found Power Life Sciences: a company that helps patients access randomized controlled trials.