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Behavioural Intervention

Cognitive Rehabilitation for Post-COVID Syndrome

N/A

Recruiting

Led By Anna E Boone, PhD, OTR/L

Research Sponsored by University of Missouri-Columbia

Eligibility Criteria Checklist

Specific guidelines that determine who can or cannot participate in a clinical trial

Must have

Self-reported cognitive symptoms persisting for at least 6 weeks following COVID-19 infection (Cognitive Failures Questionnaire (CFQ) score >43)

Be between 18 and 65 years old

Timeline

Screening 3 weeks

Treatment Varies

Follow Up pre-intervention (week 0), week 2, week 4, week 6, week 8, and post-intervention (week 12)

Awards & highlights

Study Summary

This trial will assess if a remote therapy called CO-OP can help people with PCS and cognitive impairments with activity performance, cognition, and quality of life.

Who is the study for?

This trial is for individuals who have had COVID-19 and are struggling with cognitive issues at least 6 weeks after infection. Participants should be able to set personal goals, speak English fluently, give informed consent electronically, and have a past diagnosis of COVID-19. People with severe depression, untreated sleep apnea, prior cancer treatment, serious neurological or psychiatric conditions, or signs of dementia are not eligible.Check my eligibility

What is being tested?

The study tests if CO-OP (Cognitive Orientation to daily Occupational Performance) delivered remotely can help improve everyday activity performance, cognition and quality of life in people with Post-COVID Syndrome compared to an inactive control group.See study design

What are the potential side effects?

Since the intervention involves cognitive rehabilitation procedures rather than medication or invasive therapy, significant side effects are not anticipated. However, participants may experience fatigue or frustration during cognitive tasks.

Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below

Select...

I've had memory or thinking problems for over 6 weeks after COVID-19.

Timeline

Screening ~ 3 weeks3 visits

Treatment ~ Varies

Follow Up ~ pre-intervention (week 0), week 2, week 4, week 6, week 8, and post-intervention (week 12)

Screening ~ 3 weeks

Treatment ~ Varies

Follow Up ~pre-intervention (week 0), week 2, week 4, week 6, week 8, and post-intervention (week 12)

This trial's timeline: 3 weeks for screening, Varies for treatment, and pre-intervention (week 0), week 2, week 4, week 6, week 8, and post-intervention (week 12) for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.

Primary outcome measures

Acceptability of Intervention Measure (AIM)

Canadian Occupational Performance Measure (COPM)

Feasibility measures

+3 more

Secondary outcome measures

CANTAB Delayed Matching to Sample Subtest

CANTAB Paired Associates Learning Subtest

CANTAB Spatial Working Memory Subtest

+5 more

Trial Design

2Treatment groups

Experimental Treatment

Active Control

Group I: Cognitive Orientation to daily Occupational Performance (CO-OP)Experimental Treatment1 Intervention

Each CO-OP session will last 45 minutes and subjects will complete one session per week over the course of 10 weeks. All sessions will be delivered remotely via the Zoom platform.

Group II: Inactive Control GroupActive Control1 Intervention

Subjects will complete one session per week over the course of 10 weeks. All sessions will be delivered remotely via the Zoom platform.

0 / 1Eligibility criteria met

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Who is running the clinical trial?

Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)NIH

1,965 Previous Clinical Trials

2,672,732 Total Patients Enrolled

University of Missouri-ColumbiaLead Sponsor

362 Previous Clinical Trials

628,049 Total Patients Enrolled

Anna E Boone, PhD, OTR/LPrincipal InvestigatorUniversity of Missouri Occupational Therapy

2 Previous Clinical Trials

72 Total Patients Enrolled

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Who qualifies for participation in this research program?

"To be considered for this clinical trial, individuals must meet the criteria of having post-covid syndrome and being aged between 18 to 60. A total number of 65 people are accepted in this research program."

Answered by AI

Is there an open invitation for participants to join this clinical experiment?

"According to clinicaltrials.gov, the trial is not actively searching for patients; although it was initially posted on December 1st 2023 and last updated November 14th 2023. Despite this news, there are a plethora of other trials recruiting participants at this time - 2141 in total!"

Answered by AI

Does this trial extend to minors under the age of 20?

"This trial exclusively seeks participants between the ages of 18 and 60. As an alternative, there are 476 trials catering to minors and 1609 clinical studies for those aged 65 or over."

Answered by AI

What objectives are researchers attempting to achieve with this medical experiment?

"This clinical trial seeks to evaluate its main objective, Telehealth Usability Questionnaire (TUQ), via data collection over a 12-week period. Additionally, Patient-Reported Outcome Measurement Information System (PROMIS) Cognitive Function will be evaluated using self-report measurements with higher scores indicating fewer perceived cognitive deficits. Other secondary objectives include World Health Organization Quality of Life Assessment Instrument (WHOQOL-100) and Cambridge Neuropsychological Test Automated Battery (CANTAB). The former uses self-reported responses while the latter is an objective measure of sustained attention which includes parameters such as latency, false alarms, sensitivity"

Answered by AI

Recent research and studies

Neurorehabilitation and Neural RepairJournal

Combined Cognitive-strategy and Task-specific Training Improve Transfer to Untrained Activities in Subacute Stroke

McEwen, Sara, Helene Polatajko, Carolyn Baum, Jorge Rios, Dianne Cirone, Meghan Doherty, and Timothy Wolf. 2014. “Combined Cognitive-strategy and Task-specific Training Improve Transfer to Untrained Activities in Subacute Stroke”. Neurorehabilitation and Neural Repair. SAGE Publications. doi:10.1177/1545968314558602.

The American Journal of Occupational TherapyJournal

Combined Cognitive-strategy and Task-specific Training Affects Cognition and Upper-extremity Function in Subacute Stroke: An Exploratory Randomized Controlled Trial

Wolf, Timothy J., Helene Polatajko, Carolyn Baum, Jorge Rios, Dianne Cirone, Meghan Doherty, and Sara McEwen. 2016. “Combined Cognitive-strategy and Task-specific Training Affects Cognition and Upper-extremity Function in Subacute Stroke: An Exploratory Randomized Controlled Trial”. The American Journal of Occupational Therapy. AOTA Press. doi:10.5014/ajot.2016.017293.

clinicaltrials.govStudy

Cognitive Rehabilitation in Post-COVID-19 Syndrome

Anna Boone 2024. "Cognitive Rehabilitation in Post-COVID-19 Syndrome". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT06136871.

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