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Tivozanib + Enzalutamide for Prostate Cancer
Study Summary
This trial is testing whether a combination of two drugs, one of which is already approved to treat prostate cancer, is more effective in delaying the progression of disease than the approved drug used alone. The drugs work in different ways to fight the cancer.
Eligibility Criteria
Inclusion Criteria
You may be eligible if you check “Yes” for the criteria belowTimeline
Treatment Details
Study Objectives
Outcome measures can provide a clearer picture of what you can expect from a treatment.Trial Design
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Who is running the clinical trial?
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- I have previously been treated with enzalutamide, TOK-001, or ARN-509.I have had more than two chemotherapy treatments for advanced prostate cancer.I have cancer that has spread to my brain.I am allergic to medications similar to tivozanib or enzalutamide.I haven't had major surgery in the last 4 weeks or minor surgery in the last 2 weeks.I have a history of seizures or a condition that could lead to seizures.I have a serious heart condition.I cannot take pills properly due to my stomach or bowel issues.My prostate cancer has spread, as shown on scans.I stopped any hormonal treatments like antiandrogens or ketoconazole 2 weeks ago.I do not have a serious infection or one needing IV antibiotics.I do not have active stomach ulcers, severe bowel conditions, or recent serious abdominal issues.I haven't had serious blood clots or vascular issues in the last 6 months.I have another active cancer besides non-melanoma skin cancer, in situ cervical cancer, or certain breast cancers.I have a condition or take medication that weakens my immune system.My prostate cancer has spread and cannot be surgically removed or cured with standard treatments.My prostate cancer is worsening despite hormone therapy.I had docetaxel chemotherapy for prostate cancer within the last year and stopped it at least 3 weeks ago.I haven't had any major bleeding issues in the last 6 months.I have a wound, bone fracture, or skin ulcer that is not healing.
- Group 1: Experimental Treatment Arm
- All Individual Drugs Already Approved - Therapies where all constituent drugs have already been approved are likely to have better-understood side effect profiles.
- No Placebo-Only Group - All patients enrolled in this study will receive some form of active treatment.
- Screening: It may take up to 3 Weeks to process to see if you qualify in this trial.
- Treatment: The duration you will receive the treatment varies.
- Follow Ups: You may be asked to continue sharing information regarding the trial for 6 Months after you stop receiving the treatment.
Frequently Asked Questions
What is the primary reason for taking Enzalutamide?
"Enzalutamide is typically used to battle disease progression after prior cytokine therapy and can be taken for various purposes like treating advanced renal cell carcinoma (arcc), krn 951, castration."
Is enrollment still open for this experiment?
"Unfortunately, recruitment for this trial has ceased. It was first posted on September 3rd 2013 and its last update occured on October 25th 2021. However, there are a total of 1422 active clinical trials related to prostate cancer and Enzalutamide which may still be available to join."
What prior studies have been conducted with Enzalutamide?
"Presently, 101 studies are running for Enzalutamide with 31 of them in their third phase. Most trials are occurring out of Germantown, Tennessee but 5941 other sites also have active clinical research underway."
Are there known risks associated with Enzalutamide use?
"Based on the data available, our team at Power gave Enzalutamide a safety rating of 2. This is because while there is some evidence of its security, no clinical studies have been conducted to assess efficacy yet."
How many participants are contributing to this research endeavor?
"Unfortunately, no more candidates are being accepted for this medical trial. It was originally listed on September 3rd 2013 and last edited October 25th 2021. However, if you're looking into other studies related to prostate cancer there are 1321 active trials currently recruiting patients, with 101 of those pertaining specifically to Enzalutamide treatment."
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