Frova

Migraine without Aura, Migraine with Aura, Menstruation
Treatment
4 FDA approvals
5 Active Studies for Frova

What is Frova

FrovatriptanThe Generic name of this drug
Treatment SummaryFrovatriptan is a medication used to relieve migraine headaches, especially those related to menstruation. It works by narrowing the blood vessels in the head to reduce blood flow and reduce pain.
Frovais the brand name
Frova Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Frova
Frovatriptan
2001
9

Approved as Treatment by the FDA

Frovatriptan, commonly known as Frova, is approved by the FDA for 4 uses like Migraine With Aura and Migraine Without Aura .
Migraine With Aura
Migraine Without Aura
Migraine without Aura
Migraine with Aura

Effectiveness

How Frova Affects PatientsFrovatriptan is a medication used to treat migraines. It works by targeting certain receptors in the brain and narrowing the blood vessels around the brain that can cause headaches. It does not affect other receptors or have any significant affinity for other sites. Frovatriptan is believed to be more effective than other similar medications because it has one of the highest affinities for the 5-HT1B receptor.
How Frova works in the bodyTriptans are used to treat migraines by stimulating specific receptors in the brain. This helps to reduce inflammation and dilation of blood vessels, inhibit cell excitability, and constrict meningeal and cerebral vessels. All of these actions work together to reduce the intensity of migraines.

When to interrupt dosage

The suggested measure of Frova is contingent on the recognized condition, such as Menstruation, Migraine Without Aura and Migraine With Aura. The dosage might be seen in the table underneath, in accordance with the procedure of delivery (e.g. Tablet or Tablet, film coated).
Condition
Dosage
Administration
Menstruation
, 2.5 mg
, Tablet, film coated - Oral, Tablet, film coated, Oral, Tablet, Tablet - Oral
Migraine without Aura
, 2.5 mg
, Tablet, film coated - Oral, Tablet, film coated, Oral, Tablet, Tablet - Oral
Migraine with Aura
, 2.5 mg
, Tablet, film coated - Oral, Tablet, film coated, Oral, Tablet, Tablet - Oral

Warnings

Frova has fifteen contraindications and should not be utilized in combination with any of the situations detailed in the following table.Frova Contraindications
Condition
Risk Level
Notes
Stroke
Do Not Combine
Migraine Disorders
Do Not Combine
Pulse Frequency
Do Not Combine
Atrioventricular Block
Do Not Combine
Pulse Frequency
Do Not Combine
Vasospastic Angina
Do Not Combine
Transient Ischemic Attack
Do Not Combine
Pulse Frequency
Do Not Combine
Coronary Vasospasm
Do Not Combine
Coronary Artery Disease
Do Not Combine
intestinal ischemia
Do Not Combine
Peripheral Vascular Disease
Do Not Combine
Atrial Fibrillation
Do Not Combine
Hypertensive disease
Do Not Combine
Basilar-Type Migraine
Do Not Combine
There are 20 known major drug interactions with Frova.
Common Frova Drug Interactions
Drug Name
Risk Level
Description
Azelastine
Major
Frovatriptan may increase the central nervous system depressant (CNS depressant) activities of Azelastine.
Ethanol
Major
Frovatriptan may increase the central nervous system depressant (CNS depressant) activities of Ethanol.
Methylene blue
Major
Frovatriptan may increase the serotonergic activities of Methylene blue.
Mirtazapine
Major
Frovatriptan may increase the serotonergic activities of Mirtazapine.
Oliceridine
Major
The risk or severity of hypotension, sedation, death, somnolence, and respiratory depression can be increased when Frovatriptan is combined with Oliceridine.
Frova Toxicity & Overdose RiskTaking an overdose of Frovatriptan has not been reported in any patients, but in testing, doses up to 40 times the usual dose were given to migraine patients and up to 100 times the usual dose was given to healthy male subjects without major side effects.
image of a doctor in a lab doing drug, clinical research

Frova Novel Uses: Which Conditions Have a Clinical Trial Featuring Frova?

4 active studies are currently examining the potential of Frova to provide relief from Migraine Without Aura, Migraine With Aura and Menstrual-related issues.
Condition
Clinical Trials
Trial Phases
Menstruation
2 Actively Recruiting
Phase 4, Phase 3
Migraine with Aura
0 Actively Recruiting
Migraine without Aura
3 Actively Recruiting
Not Applicable

Frova Reviews: What are patients saying about Frova?

5Patient Review
10/1/2013
Frova for Migraine Headache
I had a stroke when I was 8 and tried many different treatments over the years, but either I was allergic to them or they had major side effects. Frova is the first treatment that has worked for me with no side effects.
5Patient Review
5/13/2014
Frova for Migraine Headache
Frova is an expensive but very effective migraine medication. I've tried everything else on the market, and this is by far the best option available. If you can afford it, it's definitely worth trying!
5Patient Review
9/20/2014
Frova for Migraine Headache
This medication has been fantastic for me in regards to alleviating migraines brought on by allergies. It almost always works within thirty minutes, and I haven't experienced any negative side effects.
5Patient Review
5/12/2014
Frova for Migraine Headache
Though it's very effective, the cost is unfortunately prohibitive. I can't afford $536 for just 12 pills, and my insurance won't cover it. So sadly, I have to go without this medication.
5Patient Review
8/31/2015
Frova for Migraine Headache
I've been using Frova for a few years now and it's been really successful in treating my migraines. It takes longer to start working than other medications, but it lasts for 24 hours, which is great. I rarely have to take a second dose. The sooner you take it, the better the results will be. However, it is very expensive and insurance companies often don't want to cover it as a first choice treatment option. This is frustrating because usually you have to try other treatments first before they'll cover Frova.
View All Reviews
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Patient Q&A Section about frova

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Is there a generic for frova?

"The U.S. Food and Drug Administration (FDA) has approved Mylan N.V.’s (NASDAQ: MYL) Abbreviated New Drug Application (ANDA) for frovatriptan succinate tablets, 2.5 mg, the generic version of Endo Pharmaceuticals’ Frova® tablets.

Mylan N.V. has launched the generic equivalent of Endo Pharmaceuticals' Frova tablets, frovatriptan succinate tablets, 2.5 mg. The U.S. Food and Drug Administration (FDA) has approved Mylan N.V.'s Abbreviated New Drug Application (ANDA) for the product."

Answered by AI

What is frova used for?

"This medication is used to treat migraines and relieve symptoms including headache, pain, nausea, vomiting, and sensitivity to light/sound. It is most effective when taken at the first sign of a migraine."

Answered by AI

What is a common side effects of frovatriptan?

"You may experience dizziness, headache, dry mouth, indigestion, drowsiness, excessive tiredness, flushing, or a hot or cold feeling."

Answered by AI

How long does it take for frova to work?

"25% of patients who took frovatriptan reported feeling relief from their headaches within 1.3 to 1.7 hours. The median time it took frovatriptan to provide relief was 2.3 to 3.8 hours, as opposed to 4.4 to 8.5 hours for placebo."

Answered by AI

Clinical Trials for Frova

Have you considered Frova clinical trials? We made a collection of clinical trials featuring Frova, we think they might fit your search criteria.
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