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What is Frova
FrovatriptanThe Generic name of this drug
Treatment SummaryFrovatriptan is a medication used to relieve migraine headaches, especially those related to menstruation. It works by narrowing the blood vessels in the head to reduce blood flow and reduce pain.
Frovais the brand name
Frova Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Frova
Frovatriptan
2001
9
Approved as Treatment by the FDA
Frovatriptan, commonly known as Frova, is approved by the FDA for 2 uses like Migraine Without Aura and Migraine With Aura .Migraine Without Aura
Migraine With Aura
Effectiveness
How Frova Affects PatientsFrovatriptan is a medication used to treat migraines. It works by targeting certain receptors in the brain and narrowing the blood vessels around the brain that can cause headaches. It does not affect other receptors or have any significant affinity for other sites. Frovatriptan is believed to be more effective than other similar medications because it has one of the highest affinities for the 5-HT1B receptor.
How Frova works in the bodyTriptans are used to treat migraines by stimulating specific receptors in the brain. This helps to reduce inflammation and dilation of blood vessels, inhibit cell excitability, and constrict meningeal and cerebral vessels. All of these actions work together to reduce the intensity of migraines.
When to interrupt dosage
The suggested measure of Frova is contingent on the recognized condition, such as Menstruation, Migraine Without Aura and Migraine With Aura. The dosage might be seen in the table underneath, in accordance with the procedure of delivery (e.g. Tablet or Tablet, film coated).Condition
Dosage
Administration
Menstruation
, 2.5 mg
, Tablet, film coated - Oral, Tablet, film coated, Oral, Tablet, Tablet - Oral
Migraine With Aura
, 2.5 mg
, Tablet, film coated - Oral, Tablet, film coated, Oral, Tablet, Tablet - Oral
Migraine Without Aura
, 2.5 mg
, Tablet, film coated - Oral, Tablet, film coated, Oral, Tablet, Tablet - Oral
Warnings
Frova has fifteen contraindications and should not be utilized in combination with any of the situations detailed in the following table.Frova ContraindicationsCondition
Risk Level
Notes
history of stroke
Do Not Combine
Migraine Disorders
Do Not Combine
Pulse Frequency
Do Not Combine
Anomalous atrioventricular excitation
Do Not Combine
Pulse Frequency
Do Not Combine
Vasospastic Angina
Do Not Combine
Transient Ischemic Attack
Do Not Combine
Pulse Frequency
Do Not Combine
Coronary Artery Vasospasm
Do Not Combine
Ischaemic coronary artery disorders
Do Not Combine
intestinal ischemia
Do Not Combine
Peripheral Vascular Disease
Do Not Combine
Atrial Fibrillation
Do Not Combine
Hypertensive disease
Do Not Combine
Basilar-Type Migraine
Do Not Combine
Common Frova Drug Interactions
Drug Name
Risk Level
Description
Azelastine
Major
Frovatriptan may increase the central nervous system depressant (CNS depressant) activities of Azelastine.
Ethanol
Major
Frovatriptan may increase the central nervous system depressant (CNS depressant) activities of Ethanol.
Methylene blue
Major
Frovatriptan may increase the serotonergic activities of Methylene blue.
Mirtazapine
Major
Frovatriptan may increase the serotonergic activities of Mirtazapine.
Oliceridine
Major
The risk or severity of hypotension, sedation, death, somnolence, and respiratory depression can be increased when Frovatriptan is combined with Oliceridine.
Frova Toxicity & Overdose RiskTaking an overdose of Frovatriptan has not been reported in any patients, but in testing, doses up to 40 times the usual dose were given to migraine patients and up to 100 times the usual dose was given to healthy male subjects without major side effects.
Frova Novel Uses: Which Conditions Have a Clinical Trial Featuring Frova?
4 active studies are currently examining the potential of Frova to provide relief from Migraine Without Aura, Migraine With Aura and Menstrual-related issues.Condition
Clinical Trials
Trial Phases
Menstruation
1 Actively Recruiting
Phase 4
Migraine Without Aura
2 Actively Recruiting
Not Applicable
Migraine With Aura
3 Actively Recruiting
Not Applicable
Frova Reviews: What are patients saying about Frova?
5Patient Review
10/1/2013 I had a stroke when I was 8 and tried many different treatments over the years, but either I was allergic to them or they had major side effects. Frova is the first treatment that has worked for me with no side effects.
5Patient Review
5/13/2014 Frova is an expensive but very effective migraine medication. I've tried everything else on the market, and this is by far the best option available. If you can afford it, it's definitely worth trying!
5Patient Review
9/20/2014 This medication has been fantastic for me in regards to alleviating migraines brought on by allergies. It almost always works within thirty minutes, and I haven't experienced any negative side effects.
5Patient Review
5/12/2014 Though it's very effective, the cost is unfortunately prohibitive. I can't afford $536 for just 12 pills, and my insurance won't cover it. So sadly, I have to go without this medication.
5Patient Review
8/31/2015 I've been using Frova for a few years now and it's been really successful in treating my migraines. It takes longer to start working than other medications, but it lasts for 24 hours, which is great. I rarely have to take a second dose. The sooner you take it, the better the results will be. However, it is very expensive and insurance companies often don't want to cover it as a first choice treatment option. This is frustrating because usually you have to try other treatments first before they'll cover Frova.
5Patient Review
7/27/2015 I've been using this medication for years to great success. It's always worked quickly for me and I haven't needed to take a second dose very often. The side effects are practically nonexistent, which is amazing. Yes, it's expensive; however, the relief it brings is worth every penny.
5Patient Review
11/26/20115Patient Review
2/20/2014 Frova is an excellent medication for migraines, however the COST IS OUTRAGEOUS! There are other drugs that have generics and work just as well.
5Patient Review
3/2/2014 This medication is expensive, but it completely relieved a five-day migraine the first time I took it.
5Patient Review
3/21/2014 Frova is the best medication I have taken for my chronic migraines; however it is $50 per pill. I can't afford it, I hope a generic comes out soon.
4.7Patient Review
3/14/2015 I find that Frova is most effective when taken at the first sign of a migraine. However, it can be expensive to use on a regular basis.
4.7Patient Review
4/25/2015 I've tried many treatments before this one, and this is by far the best. I very rarely have to take a second dose in 24 hours. However, it is expensive. My insurance company does cover it, but I still have to pay $60 for 12 pills.
4.7Patient Review
9/2/2013 I've had migraines for fifteen years and this is the only medication that has provided any relief. Sometimes I need a second dose, but it's better than nothing.
4.3Patient Review
1/17/2012 This drug has been effective in making migraines manageable. I can usually take it at the beginning of a migraine and have it work relatively quickly. The drowsiness and increased urination are annoying, but tolerable side effects.
2Patient Review
10/21/2013 This medication was way too expensive and it didn't even work. I had to spend quite a bit of money on this, and as a result my kids missed out on some meals. This was a terrible trade-off that I wouldn't recommend to anyone.
1Patient Review
11/6/2014 Frova was a complete disappointment and did nothing to help my migraines. Imitrex is the only thing that works for me.
Patient Q&A Section about frova
These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.Is there a generic for frova?
"The U.S. Food and Drug Administration (FDA) has approved Mylan N.V.’s (NASDAQ: MYL) Abbreviated New Drug Application (ANDA) for frovatriptan succinate tablets, 2.5 mg, the generic version of Endo Pharmaceuticals’ Frova® tablets.
Mylan N.V. has launched the generic equivalent of Endo Pharmaceuticals' Frova tablets, frovatriptan succinate tablets, 2.5 mg. The U.S. Food and Drug Administration (FDA) has approved Mylan N.V.'s Abbreviated New Drug Application (ANDA) for the product."
Answered by AI
What is a common side effects of frovatriptan?
"You may experience dizziness, headache, dry mouth, indigestion, drowsiness, excessive tiredness, flushing, or a hot or cold feeling."
Answered by AI
How long does it take for frova to work?
"25% of patients who took frovatriptan reported feeling relief from their headaches within 1.3 to 1.7 hours. The median time it took frovatriptan to provide relief was 2.3 to 3.8 hours, as opposed to 4.4 to 8.5 hours for placebo."
Answered by AI