Darvocet

Chronic Pain
Treatment
2 FDA approvals
20 Active Studies for Darvocet

What is Darvocet

DextropropoxypheneThe Generic name of this drug
Treatment SummaryAcetaminophen, also known as Tylenol, is a widely-used pain relief medication. It can also be used to reduce fever. Acetaminophen is available in many different forms, such as syrup, regular tablets, effervescent tablets, injection, suppository, and other forms. It is also often combined with other drugs in over 600 over-the-counter allergy, cold, sleep, and pain relief medications. It is important to follow dosing guidelines when taking acetaminophen, as incorrect use can lead to fatal overdose or liver failure.
Propoxypheneis the brand name
image of different drug pills on a surface
Darvocet Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Propoxyphene
Dextropropoxyphene
1973
64

Approved as Treatment by the FDA

Dextropropoxyphene, also known as Propoxyphene, is approved by the FDA for 2 uses like Chronic Pain and Pain .
Chronic Pain
Helps manage Pain
Pain
Helps manage Pain

Effectiveness

How Darvocet Affects PatientsAcetaminophen has been found to reduce fever and pain, but does not reduce inflammation. It does not interfere with the body's uric acid balance like some other painkillers, and it does not stop blood clotting or make it harder for platelets to form clots. Allergic reactions to acetaminophen are rare.
How Darvocet works in the bodyAcetaminophen is thought to reduce pain by blocking an enzyme called cyclooxygenase (COX). This enzyme is involved in the production of pain-causing chemicals called prostaglandins. Acetaminophen does not block COX in all parts of the body, so it does not have the same anti-inflammatory effects as NSAIDs. It is also believed to work on brain centers that regulate body temperature, causing you to sweat and lose heat. The exact way acetaminophen works is still not fully understood.

When to interrupt dosage

The measure of Darvocet is contingent upon the diagnosed affliction, such as Pain, Spasm and Inflammation. The amount of dosage also relies on the approach of administration detailed in the table beneath.
Condition
Dosage
Administration
Chronic Pain
, 65.0 mg, 100.0 mg, 50.0 mg
, Oral, Tablet, film coated, Tablet, film coated - Oral, Capsule, Capsule - Oral, Tablet, Tablet - Oral

Warnings

Darvocet Contraindications
Condition
Risk Level
Notes
Hypercarbia
Do Not Combine
Asthma
Do Not Combine
Mental Depression
Do Not Combine
Intestinal Pseudo-Obstruction
Do Not Combine
Asthma
Do Not Combine
There are 20 known major drug interactions with Darvocet.
Common Darvocet Drug Interactions
Drug Name
Risk Level
Description
7,8-Dichloro-1,2,3,4-tetrahydroisoquinoline
Major
The risk or severity of adverse effects can be increased when Dextropropoxyphene is combined with 7,8-Dichloro-1,2,3,4-tetrahydroisoquinoline.
Abemaciclib
Major
The metabolism of Abemaciclib can be decreased when combined with Dextropropoxyphene.
Acalabrutinib
Major
The metabolism of Acalabrutinib can be decreased when combined with Dextropropoxyphene.
Alectinib
Major
The metabolism of Alectinib can be decreased when combined with Dextropropoxyphene.
Alpelisib
Major
The metabolism of Alpelisib can be decreased when combined with Dextropropoxyphene.
Darvocet Toxicity & Overdose RiskAcetaminophen is toxic in large doses and can cause kidney damage, low blood sugar, low platelet count, and liver failure. In rare cases, it has been linked to cancer in female rats. It can also cause chromosome disruption at high doses, but no evidence of this has been seen in humans. Acetaminophen has not been linked to fertility issues, but it is still categorized as a pregnancy category C drug, meaning it has shown adverse effects in animals. It can be found in breast milk in small amounts and should be used cautiously by nursing mothers.
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Darvocet Novel Uses: Which Conditions Have a Clinical Trial Featuring Darvocet?

698 active studies are currently in progress to investigate the efficacy of Darvocet in alleviating Chronic Pain, Rheumatoid Arthritis and Allergic Symptoms.
Condition
Clinical Trials
Trial Phases
Chronic Pain
129 Actively Recruiting
Not Applicable, Phase 2, Phase 4, Phase 3, Early Phase 1, Phase 1

Darvocet Reviews: What are patients saying about Darvocet?

5Patient Review
2/19/2014
Darvocet for Pain
I found this to be the most effective pain medication I've ever tried. My doctor was very surprised that it was no longer available on the market.
5Patient Review
12/3/2012
Darvocet for Pain
Darvocet-N 100 is the only medication I've found that doesn't make me nauseous, have abdominal discomfort, or go into anaphylactic shock (as I'm allergic to Codiene). Dealing with all the medication is tough, but this at least makes it manageable.
5Patient Review
1/18/2013
Darvocet for Pain
This treatment has been life-changing for me. It's helped me to walk and live again.
5Patient Review
12/29/2012
Darvocet for Pain
I found this treatment to be successful and hope there is something similar on the market now.
5Patient Review
3/9/2013
Darvocet for Pain
This is by far the best pain medication I've ever taken. Most others give me terrible rashes and itchiness, but this one doesn't.
5Patient Review
7/2/2014
Darvocet for Pain
This was the only pain medication that put a dent in my agony during an infected wisdom tooth issue. Only on it a short time.
5Patient Review
3/15/2012
Darvocet for Pain
5Patient Review
5/19/2012
Darvocet for Pain
5Patient Review
6/10/2012
Darvocet for Pain
5Patient Review
9/17/2012
Darvocet for Pain
5Patient Review
1/31/2013
Darvocet for Pain
I never felt like I took too much.
4.7Patient Review
6/8/2012
Darvocet for Pain
4Patient Review
6/19/2012
Darvocet for Pain
3.7Patient Review
11/18/2013
Darvocet for Pain
I saw great results from this treatment, but I'm wondering if there are any side effects for people with high blood pressure?
3Patient Review
6/2/2014
Darvocet for Pain
This is the only pain medication I can take without any side effects or problems with aspirin allergy.
1.3Patient Review
2/12/2013
Darvocet for Pain
I have terrible arthritis and fibromylgia. This was the best pain med I ever took.
image of drug pills surrounding a glass of water symbolizing drug consumption

Patient Q&A Section about darvocet

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

What has replaced Darvocet?

"The drugs most commonly used as replacements for Darvocet are Buprenorphine and Suboxone."

Answered by AI

Why did Darvocet get recalled?

"The FDA has recalled the popular painkillers Darvocet and Darvon because they pose an unreasonable risk of heart problems."

Answered by AI

Do they still make the drug Darvocet?

"Propoxyphene, one of the most commonly prescribed medications in America, has been removed from the market following a thorough review by the FDA which concluded that the risks associated with propoxyphene outweigh the benefits."

Answered by AI

Clinical Trials for Darvocet

Image of Vanderbilt University Medical Center in Nashville, United States.

Lidocaine Infusions for Postoperative Pain

18+
All Sexes
Nashville, TN
The goal of this single-center, pragmatic, randomized, blinded, placebo-controlled trial is to evaluate the impact of intravenous (IV) lidocaine within the existing Enhanced Recovery After Surgery (ERAS)program on outcomes in patients after major abdominal surgery. The main questions the trial aims to answer are: The primary hypothesis is that utilization of IV lidocaine as part of a perioperative multimodal pain regimen will result in a reduction in hospital Case Mix Index-Adjusted Resource Length of Stay (CARLOS). The secondary hypotheses are that lidocaine infusion will result in a reduction in total inpatient opioid consumption (oral morphine milligram equivalents, oMMEs) and pain scores, and improved surgical outcomes (including return of bowel function, ileus, nausea, rapid responses called, surgical site infections, and ICU transfers), while also having minimal incidence of side effects (including double/blurry vision, tinnitus, sedation, and adverse events requiring early cessation).
Phase 4
Waitlist Available
Vanderbilt University Medical CenterDanial Shams, MD
Have you considered Darvocet clinical trials? We made a collection of clinical trials featuring Darvocet, we think they might fit your search criteria.Go to Trials
Image of University Hospitals Cleveland Medical Center in Cleveland, United States.

Erector Spinae Plane Block for Pain

21 - 75
All Sexes
Cleveland, OH
As per usual care for spine surgery, participants will have their back cleaned with alcohol and a needle will be placed using ultrasound for the ESP block. Through the needle, a small catheter will be placed in the participants back and the needle removed. Approximately one hour prior to the start of surgery, a numbing medication (ropivacaine, similar to Novocaine) in combination with dexmedetomidine (a pain medicine that is used in nerve block and that is not a narcotic) and contrast dye (iohexol) will be injected through the catheter. Participants will then go through the QST procedure (test of buzzing sensation and temperature sensation through pads applied to their skin) to assess the numb areas and then head to the operating room. In the operating room, the catheter will be removed after the surgeon obtains baseline CT scan images of the spine. Once surgery is completed, investigators will record pain scores over the next four days in the hospital and the amount of pain medication needed for controlling pain related to the surgery.
Recruiting
Has No Placebo
University Hospitals Cleveland Medical CenterSalim Hayek, MD
Have you considered Darvocet clinical trials? We made a collection of clinical trials featuring Darvocet, we think they might fit your search criteria.Go to Trials
Image of BC Children's Hospital in Vancouver, Canada.

Digital Media for Anxiety in Children

5 - 23
All Sexes
Vancouver, Canada
The goal of this clinical trial is to learn whether different forms of media (2D, 360, or 360 in virtual reality) have different impacts on pre-procedural anxiety and post-procedural pain in children. The main questions it aims to answer are: Does one type (and richness) of media reduce pre-procedural anxiety and post-procedural pain more than another type of media? For example, will learning about an upcoming procedure by watching a 360 video in virtual reality reduce pre-procedural anxiety more than learning about the same upcoming procedure by watching it in a 2D video or 360 video? The second question is whether watching a 360 video in VR about an upcoming procedure more effective in reducing pre-procedural anxiety and post-procedural pain compared to the 2D video or the 360 video without VR groups for specific procedures? For example, is watching an explanation of a procedure in VR always more effective in reducing pre-procedural anxiety and post-procedural pain, or is it procedure specific (i.e., watching a video about surgery preparation is more effective in VR, but for cast removal it doesn't matter whether participants learn about their procedure viewed through VR, 360 video, or 2D)?
Recruiting
Has No Placebo
BC Children's Hospital
Image of Active Aging Research Team, Robert H. N. Ho Research Centre in Vancouver, Canada.

Choose to Move Replacement Ready for Osteoarthritis

18+
All Sexes
Vancouver, Canada
Choose to Move (CTM) is a 3-month, choice-based health-promoting program for low active older adults being scaled-up across British Columbia (BC), Canada. Recently, the investigators adapted CTM for the \>14000 people in BC who are on surgical waitlists for total knee replacement or total hip replacement (TKR/THR) for osteoarthritis (OA). The primary goal of this observational study is to learn if the adapted program, Choose to Move Replacement Ready (CTM-RR), is feasible to deliver to people with hip and/or knee osteoarthritis who are on surgical waitlists for TKR/THR. Participants who enrol in CTM-RR will answer online survey questions about the program and about their physical activity, mobility, pain, function, quality of life, willingness to undergo surgery, overall perception of their joint condition, psychosocial health, self-efficacy, social isolation, loneliness, and sedentary time. CTM-RR activity coaches will also answer online survey questions about the program. CTM-RR participants, activity coaches, and referral partners will also participate in interviews about the program.
Recruiting
Has No Placebo
Active Aging Research Team, Robert H. N. Ho Research CentreHeather A. McKay, PhD
Have you considered Darvocet clinical trials? We made a collection of clinical trials featuring Darvocet, we think they might fit your search criteria.Go to Trials
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