Buffered Injection for Pain

Phase-Based Progress Estimates
1
Effectiveness
1
Safety
Pain
Buffered Injection - Procedure
Eligibility
18+
All Sexes
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Study Summary

This trial will collect data from multiple academic institutions to study the effect of anesthetic injection rate and temperature on pain perception during dermatologic procedures, as well as if buffering the anesthetic solution alters pain perception.

Treatment Effectiveness

Study Objectives

1 Primary · 0 Secondary · Reporting Duration: intraoperative

intraoperative
Pain on a Visual Analog Scale (VAS)

Trial Safety

Trial Design

6 Treatment Groups

Slow, Room Temperature
1 of 6
Slow, Warmed
1 of 6
Rapid, Room Temperature
1 of 6
Buffered
1 of 6
Rapid, Warmed
1 of 6
Non-Buffered
1 of 6

Experimental Treatment

Non-Treatment Group

26 Total Participants · 6 Treatment Groups

Primary Treatment: Buffered Injection · Has Placebo Group · N/A

Slow, Room TemperatureExperimental Group · 3 Interventions: Buffer, Slow, Room Temperature Injection, Lidocaine · Intervention Types: Drug, Procedure, Drug
Slow, WarmedExperimental Group · 3 Interventions: Buffer, Slow, Warm Temperature Injection, Lidocaine · Intervention Types: Drug, Procedure, Drug
Rapid, Room TemperatureExperimental Group · 3 Interventions: Buffer, Lidocaine, Rapid, Room Temperature Injection · Intervention Types: Drug, Drug, Procedure
BufferedExperimental Group · 3 Interventions: Buffer, Buffered Injection, Lidocaine · Intervention Types: Drug, Procedure, Drug
Rapid, WarmedExperimental Group · 3 Interventions: Buffer, Rapid, Warm Temperature Injection, Lidocaine · Intervention Types: Drug, Procedure, Drug
Non-BufferedPlaceboComparator Group · 2 Interventions: Non-Buffered Injection, Lidocaine · Intervention Types: Procedure, Drug
Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
Buffer
2012
N/A
~310
Lidocaine
FDA approved

Trial Logistics

Trial Timeline

Screening: ~3 weeks
Treatment: Varies
Reporting: intraoperative

Who is running the clinical trial?

Northwestern UniversityLead Sponsor
1,432 Previous Clinical Trials
769,502 Total Patients Enrolled
44 Trials studying Pain
3,830 Patients Enrolled for Pain
Murad Alam, MDPrincipal InvestigatorNorthwestern University
69 Previous Clinical Trials
2,653 Total Patients Enrolled
3 Trials studying Pain
175 Patients Enrolled for Pain

Eligibility Criteria

Age 18+ · All Participants · 3 Total Inclusion Criteria

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About The Reviewer

Michael Gill preview

Michael Gill - B. Sc.

First Published: October 21st, 2021

Last Reviewed: November 27th, 2022

Michael Gill holds a Bachelors of Science in Integrated Science and Mathematics from McMaster University. During his degree he devoted considerable time modeling the pharmacodynamics of promising drug candidates. Since then, he has leveraged this knowledge of the investigational new drug ecosystem to help his father navigate clinical trials for multiple myeloma, an experience which prompted him to co-found Power Life Sciences: a company that helps patients access randomized controlled trials.