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Local Anesthetic

Varied Lidocaine Injection Methods for Pain Management

N/A

Waitlist Available

Led By Murad Alam, MD

Research Sponsored by Northwestern University

Eligibility Criteria Checklist

Specific guidelines that determine who can or cannot participate in a clinical trial

Must have

Be older than 18 years old

Timeline

Screening 3 weeks

Treatment Varies

Follow Up intraoperative

Awards & highlights

Study Summary

This trial will collect data from multiple academic institutions to study the effect of anesthetic injection rate and temperature on pain perception during dermatologic procedures, as well as if buffering the anesthetic solution alters pain perception.

Who is the study for?

This trial is for individuals aged 18-89 who are about to undergo dermatologic procedures and can understand and agree to the study's terms. It's not suitable for those who don't meet these age requirements or cannot give informed consent.Check my eligibility

What is being tested?

The study tests how pain perception changes with different lidocaine injections during skin procedures. Part A examines the effect of injection speed and temperature, while Part B looks at whether adding a buffer to the anesthetic alters pain levels.See study design

What are the potential side effects?

Potential side effects may include discomfort or pain at the injection site, possible bruising or bleeding, allergic reactions to lidocaine, or temporary numbness in the area treated.

Timeline

Screening ~ 3 weeks3 visits

Treatment ~ Varies

Follow Up ~ intraoperative

Screening ~ 3 weeks

Treatment ~ Varies

Follow Up ~intraoperative

This trial's timeline: 3 weeks for screening, Varies for treatment, and intraoperative for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.

Primary outcome measures

Pain on a Visual Analog Scale (VAS)

Trial Design

6Treatment groups

Experimental Treatment

Placebo Group

Group I: Slow, WarmedExperimental Treatment3 Interventions

In Part A, subject will be randomized to receive an injection of lidocaine that is slow at room temperature, rapid at room temperature, slow at warm temperature, or rapid at warm temperature.

Group II: Slow, Room TemperatureExperimental Treatment3 Interventions

In Part A, subject will be randomized to receive an injection of lidocaine that is slow at room temperature, rapid at room temperature, slow at warm temperature, or rapid at warm temperature.

Group III: Rapid, WarmedExperimental Treatment3 Interventions

In Part A, subject will be randomized to receive an injection of lidocaine that is slow at room temperature, rapid at room temperature, slow at warm temperature, or rapid at warm temperature.

Group IV: Rapid, Room TemperatureExperimental Treatment3 Interventions

In Part A, subject will be randomized to receive an injection of lidocaine that is slow at room temperature, rapid at room temperature, slow at warm temperature, or rapid at warm temperature.

Group V: BufferedExperimental Treatment3 Interventions

In Part B, subject will be randomized to receive an injection of lidocaine that is buffered or non-buffered.

Group VI: Non-BufferedPlacebo Group2 Interventions

In Part B, subject will be randomized to receive an injection of lidocaine that is buffered or non-buffered.

Treatment

First Studied

Drug Approval Stage

How many patients have taken this drug

Lidocaine

2011

Completed Phase 4

~1360

Buffer

2012

N/A

~310

Do I qualify?Apply below to find out

Find a Location

Who is running the clinical trial?

Northwestern UniversityLead Sponsor

1,585 Previous Clinical Trials

917,205 Total Patients Enrolled

46 Trials studying Pain

3,734 Patients Enrolled for Pain

Murad Alam, MDPrincipal InvestigatorNorthwestern University

69 Previous Clinical Trials

2,554 Total Patients Enrolled

3 Trials studying Pain

175 Patients Enrolled for Pain

Media Library

Lidocaine (Local Anesthetic) Clinical Trial Eligibility Overview. Trial Name: NCT02823002 — N/A

Pain Research Study Groups: Slow, Room Temperature, Rapid, Room Temperature, Slow, Warmed, Rapid, Warmed, Buffered, Non-Buffered

Pain Clinical Trial 2023: Lidocaine Highlights & Side Effects. Trial Name: NCT02823002 — N/A

Lidocaine (Local Anesthetic) 2023 Treatment Timeline for Medical Study. Trial Name: NCT02823002 — N/A

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

What prior investigations have been conducted concerning Buffered Injection?

"At the moment, 118 studies are researching Buffered Injection with 31 of them being in phase 3. Calgary, Alberta is conducting multiple trials on this medication while 1094 sites across the world are participating as well."

Answered by AI

Would I be eligible to enroll in this scientific experiment?

"Eligibility criteria for this research requires participants to exhibit signs of pain and be aged between 18-89 years old. The total patient count of the trial is set at 26 persons."

Answered by AI

Are there opportunities to join this clinical investigation at the present time?

"The clinical trial database indicates that this study is not presently recruiting new patients. It was initially posted on June 1st 2016, and the most recent update occurred on March 2nd 2022. Although no longer seeking participants for this particular investigation, 462 other trials are currently accepting enrollees."

Answered by AI

Is this research open to octogenarians?

"The parameters for enrolment dictate that prospective participants must be between 18 to 89 years old. As a corollary, there are 81 studies recruiting minors and 348 trials targeting seniors."

Answered by AI

What types of ailments can Buffered Injection ameliorate?

"Buffered Injection is often utilized to alleviate cervical syndrome, however it can also be administered for patients with osteoporosis, minor burns and post-transplantation care."

Answered by AI

How many participants are being considered for inclusion into this trial?

"This clinical trial is no longer actively recruiting. It was initially posted on June 1st 2016, and its last edit occurred March 2nd 2022. However, if you are still seeking to participate in a study there exist 344 trials related to pain research and 118 studies for Buffered Injection that are currently enrolling patients."

Answered by AI

Recent research and studies

clinicaltrials.govStudy

Pain Perception: Lidocaine Rate/Temp/Buffer

Murad Alam 2016. "Pain Perception: Lidocaine Rate/Temp/Buffer". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT02823002.

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