Aerobic Training for Hypermetria

Phase-Based Progress Estimates
1
Effectiveness
1
Safety
Columbia University Irving Medical Center, New York, NY
Hypermetria+2 More
Aerobic Training - Behavioral
Eligibility
18+
All Sexes
Eligible conditions
Select

Study Summary

This study is evaluating whether balance training or aerobic training is more effective for treating degenerative cerebellar diseases.

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Eligible Conditions

  • Hypermetria

Treatment Effectiveness

Effectiveness Estimate

1 of 3

Study Objectives

This trial is evaluating whether Aerobic Training will improve 1 primary outcome and 6 secondary outcomes in patients with Hypermetria. Measurement will happen over the course of 6 months.

6 months
Prevalence of desired changes in Diffuse Tensor Imaging
Prevalence of desired changes in Resting State fMRI scans
Month 12
Average gait speed
Change in Assessment and Rating of Ataxia (SARA) Score
Dynamic Gait Index score
Prevalence of Cerebellar Volume
Timed Up and Go

Trial Safety

Safety Estimate

1 of 3

Trial Design

2 Treatment Groups

Balance Training
1 of 2
Aerobic Training
1 of 2
Active Control
Experimental Treatment

This trial requires 48 total participants across 2 different treatment groups

This trial involves 2 different treatments. Aerobic Training is the primary treatment being studied. Participants will all receive the same treatment. There is no placebo group. The treatments being tested are not being studied for commercial purposes.

Aerobic Training
Behavioral
Participants will be given a stationary exercise bike for home use. They will be instructed to use the exercise bike five times a week for thirty-minute sessions. The exercise intensity prescription will be based on the subject's VO2max determined on pre-test day. The exercise program will start at 60% of intensity per session, and then will be increased by steps of 5% intensity every 2 sessions until participants reach 30 minutes of training at 80% intensity. Participants will be contacted weekly by e-mail or phone to answer any questions about the exercise protocol and will be instructed to log each training session. Subjects will record duration of exercise, perceived exertion, average heart rate, maximum heart rate, and distance.
Balance Training
Behavioral
A physical therapist will tailor a home balance training program for each participant based on pre- training capabilities. Subjects will be asked to perform exercises five times a week for thirty-minute sessions. Both dynamic and static exercises will be performed in sitting and standing positions. Exercises will start with stabilizing in a challenging static position and progress to dynamic arm and leg movements in the same or modified position. Participants will be contacted weekly by e-mail or phone to answer any questions about the exercise protocol and will be required to log their exercise effort in terms of frequency and level of balance challenge.
Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
Aerobic Training
2020
N/A
~770

Trial Logistics

Trial Timeline

Approximate Timeline
Screening: ~3 weeks
Treatment: Varies
Reporting: baseline, 6 months, 9 months, 12 months
This trial has the following approximate timeline: 3 weeks for initial screening, variable treatment timelines, and roughly baseline, 6 months, 9 months, 12 months for reporting.

Who is running the study

Principal Investigator
S. B.
Prof. Scott Barbuto, Assistant Professor of Rehabilitation and Regenerative Medicine
Columbia University

Closest Location

Columbia University Irving Medical Center - New York, NY

Eligibility Criteria

This trial is for patients born any sex aged 18 and older. There are 4 eligibility criteria to participate in this trial as listed below.

Mark “yes” if the following statements are true for you:
Diagnosed with spinocerebellar ataxia
Cerebellar atrophy on MRI
Prevalence of ataxia on clinical exam
Ability to safely ride a stationary exercise bike

Patient Q&A Section

What is cerebellar diseases?

"Cerebellar diseases are a common group of brain disorders that result in motor and gait disorders and often have symptoms similar to those of Parkinson's disease and Alzheimer's disease. The cerebellum's main functions include balance and coordination, as well as fine motor skills and processing sensory information. Cerebellar diseases manifest themselves as gait disorders. Patients with either cerebellar disease or a subtype of the cerebellar disorders often present with ataxia, incoordination, slowed movement, dysarthria (excessive noise in speech), and dysdiadochokinesia (a form of dysmetria, irregularity of movement)." - Anonymous Online Contributor

Unverified Answer

What are the signs of cerebellar diseases?

"Signs and symptoms of cerebellar diseases include neck rigidity, abnormal balance when standing, and gait abnormality when walking. Some forms of cerebellar diseases cause unsteady gait or staggering. Hearing loss is another sign. In some cases, the signs and symptoms of cerebellar diseases are quite subtle. If all of those signs are present in a patient’s history and on physical exam, medical professionals should consider an underlying cerebellar disease." - Anonymous Online Contributor

Unverified Answer

How many people get cerebellar diseases a year in the United States?

"Based on the present analysis the number of new cases in the USA per year is about 30/100,000. Approximately, 2 cases per 100,000 are diagnosed in people over 50 years of age. Of the 40,000 reported cases, 15,000 are new. However, 2 cases in 10,000 people die from cerebellar diseases. More information is needed to explain some of puzzling phenomena reported." - Anonymous Online Contributor

Unverified Answer

What causes cerebellar diseases?

"The most common causes of cerebellar diseases are congenital trauma and neurodegenerative disorders. Both congenital and neurodegenerative disorders cause cerebellar diseases, while neurodegenerative disorders often cause many kinds of cerebrovascular-related diseases as well and are therefore the main causes of cerebellar diseases. Patients with cerebellar diseases and their parents must be followed up and made aware on the proper way to prevent or treat diseases." - Anonymous Online Contributor

Unverified Answer

What are common treatments for cerebellar diseases?

"More than 40% of the patients had no medication prescription before beginning medical treatment for cerebellar diseases. In the current study, only a considerable minority used at-home physical and/or occupational therapy. The prescribed treatment depended significantly on the initial severity and a few other factors. The most common therapy was at-home physical, occupational and/or speech therapy. The prescribed treatment differed significantly between the disorders." - Anonymous Online Contributor

Unverified Answer

Can cerebellar diseases be cured?

"In a recent study, findings shows the necessity of a strict definition of "cure" for rehabilitation studies and their application in the clinical management of both patients and families." - Anonymous Online Contributor

Unverified Answer

What is the primary cause of cerebellar diseases?

"The most common cause of cerebellar diseases is idiopathic and its frequency is similar in all age groups. A definite correlation has been shown between the onset of cerebellar disease and the occurrence of hypertension and obesity which are frequently encountered in patients with cerebellar diseases." - Anonymous Online Contributor

Unverified Answer

Has aerobic training proven to be more effective than a placebo?

"Data from a recent study, which utilized double-blind random assignment, revealed that aerobic training was more effective than a placebo. This information deserves attention when designing and conducting large prospective trials on chronic degenerative diseases, if it is applicable that chronic degenerative diseases result from physical inactivity. However, it is still unknown whether the prevention or improvement programs of chronic degenerative diseases by exercise could be conducted, and exercise should be chosen according to the disease condition." - Anonymous Online Contributor

Unverified Answer

Is aerobic training safe for people?

"Aerobic training is safe and can lead to a clinically relevant response in selected patients with neurological conditions such as stroke. The underlying mechanisms should be further studied in order to develop exercise programs for patients with neurological conditions." - Anonymous Online Contributor

Unverified Answer

Is aerobic training typically used in combination with any other treatments?

"The present studies show that one of the benefits of the aerobic exercise is the recovery of brain function and that, consequently, more and more patients can have a complete recovery." - Anonymous Online Contributor

Unverified Answer

Have there been any new discoveries for treating cerebellar diseases?

"Current therapies are effective in treating cerebellar diseases; however, new technologies are needed in the development of treatments because cerebellar diseases are challenging to treat due to the brain's resilience." - Anonymous Online Contributor

Unverified Answer

What are the latest developments in aerobic training for therapeutic use?

"The current literature includes a large amount of high quality randomized controlled trials comparing aerobic exercise to no exercise in various patient groups. The scope of the methodological limitations included in both primary research and reviews is broadened by the use of more specific and high-quality techniques, such as meta-analyses rather than systematic reviews. The effect of confounding variables including treatment intensity, type of exercise, and lifestyle behaviors cannot be ruled out. The current scope of methodological limitations in the scientific literature on aerobic exercise for therapeutic use is widened by careful consideration of the methodological quality of primary and recent reviews. Further prospective trials in well-defined patient groups are needed to establish the effect of exercise in cardiovascular, cardiovascular risk, neurological and psychiatric, and musculoskeletal conditions." - Anonymous Online Contributor

Unverified Answer
Please Note: These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.
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