Ear Stimulation for Brain Activity
Trial Summary
What is the purpose of this trial?
The purpose of this study is to explore whether stimulating different outer parts of the ear using a non-invasive form of ear stimulation called transcutaneous auricular vagus nerve stimulation (taVNS) will create different brain activation images. Investigators will recruit 24 healthy participants. The ear stimulation will be delivered while taking brain images using a magnetic resonance imaging (MRI) machine.
Will I have to stop taking my current medications?
The trial does not specify if you need to stop taking your current medications, but you cannot participate if you use medications that lower the seizure threshold, like olanzapine or lithium.
What data supports the effectiveness of the treatment Transcutaneous Auricular Vagus Nerve Stimulation (taVNS)?
Research shows that taVNS is a non-invasive and cost-effective treatment that has been used to help with various conditions, including disorders of consciousness and gastric symptoms. It works by applying a small electrical current to the ear, which can influence the vagus nerve and potentially improve health outcomes.12345
Is ear stimulation for brain activity safe for humans?
How does the treatment Transcutaneous Auricular Neurostimulation (tAN) differ from other treatments for brain activity?
Transcutaneous Auricular Neurostimulation (tAN) is unique because it is a non-invasive treatment that uses low-intensity electrical currents applied to the ear to stimulate the vagus nerve, unlike other treatments that may require surgery or medication. This method is appealing due to its safety, portability, and cost-effectiveness, making it a promising alternative for various conditions without the need for invasive procedures.13489
Research Team
Xiaolong Peng
Principal Investigator
Medical University of South Carolina
Eligibility Criteria
This trial is for 24 healthy individuals interested in participating in a study to explore brain activation. Participants will undergo non-invasive ear stimulation while their brain images are taken using MRI.Inclusion Criteria
Exclusion Criteria
Timeline
Screening
Participants are screened for eligibility to participate in the trial
Treatment
Participants receive transcutaneous auricular vagus nerve stimulation (taVNS) at different ear sites while undergoing MRI scanning
Follow-up
Participants are monitored for safety and effectiveness after treatment
Treatment Details
Interventions
- Transcutaneous Auricular Neurostimulation (tAN)
Transcutaneous Auricular Neurostimulation (tAN) is already approved in United States for the following indications:
- Relief of opioid withdrawal symptoms
Find a Clinic Near You
Who Is Running the Clinical Trial?
Medical University of South Carolina
Lead Sponsor