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Exercise for Obesity Management (LG Trial)

N/A
Recruiting
Led By Jeffrey F Horowitz, PhD
Research Sponsored by University of Michigan
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Women must have regularly occurring menses and must be premenopausal
Age: 18-40
Timeline
Screening 3 weeks
Treatment Varies
Follow Up 30 minutes
Awards & highlights

LG Trial Summary

This trial is testing whether exercise helps people keep weight off after they lose it.

Who is the study for?
This trial is for adults aged 18-40 with a BMI of 27-45 who haven't been exercising regularly. Women should have regular menstrual cycles and not be pregnant or breastfeeding. People can't join if they've had heart or metabolic diseases, take meds affecting metabolism, had recent weight fluctuations, or use tobacco products.Check my eligibility
What is being tested?
The study is testing the impact of exercise on body fat and how it functions after weight loss. Participants will either follow an exercise program or no exercise while losing and then regaining weight. Their metabolic health will be tested before and after these changes.See study design
What are the potential side effects?
Since this trial involves standard physical activity as the intervention, side effects may include typical exercise-related issues such as muscle soreness, fatigue, or injury. The high-calorie diet phase could potentially lead to temporary weight gain.

LG Trial Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below
Select...
I am a woman who has regular menstrual cycles and am not in menopause.
Select...
I am between 18 and 40 years old.

LG Trial Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~30 minutes
This trial's timeline: 3 weeks for screening, Varies for treatment, and 30 minutes for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Adipose Capillarization
Adipose Tissue Fibrosis
Fat Cell Size
+2 more
Secondary outcome measures
Blood Lipid Profile
Blood Pressure

LG Trial Design

2Treatment groups
Experimental Treatment
Group I: No exerciseExperimental Treatment1 Intervention
Subjects assigned to this group are to remain sedentary (no planned physical exercise) throughout the duration of the study.
Group II: ExerciseExperimental Treatment1 Intervention
This exercise prescription represents a common or "conventional" form of physical activity (e.g., moderate/brisk walking). If assigned to this group, participants will perform 45 minutes of moderate intensity continuous steady-state exercise at 70% maximal heart rate (HRmax) to expend 250 calories 4 days per week.
Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
No exercise
2021
N/A
~550
Exercise
2016
Completed Phase 1
~760

Find a Location

Who is running the clinical trial?

University of MichiganLead Sponsor
1,797 Previous Clinical Trials
6,378,012 Total Patients Enrolled
13 Trials studying Weight Loss
6,127 Patients Enrolled for Weight Loss
Jeffrey F Horowitz, PhDPrincipal Investigator - University of Michigan, School of Kinesiology
University of Michigan
2 Previous Clinical Trials
65 Total Patients Enrolled

Media Library

Exercise Clinical Trial Eligibility Overview. Trial Name: NCT04812314 — N/A
Weight Loss Research Study Groups: Exercise, No exercise
Weight Loss Clinical Trial 2023: Exercise Highlights & Side Effects. Trial Name: NCT04812314 — N/A
Exercise 2023 Treatment Timeline for Medical Study. Trial Name: NCT04812314 — N/A
Weight Loss Patient Testimony for trial: Trial Name: NCT04812314 — N/A

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Does this trial allow for the inclusion of participants aged 18 or older?

"This clinical trial is seeking participants aged 18 to 40."

Answered by AI

How many subjects are participating in this clinical experiment?

"Affirmative. Information available on clinicaltrials.gov demonstrate that this medical investigation, which was originally posted on March 1st 2021, is presently enlisting candidates. Approximately 46 participants need to be enrolled from a single research facility."

Answered by AI

Who would qualify to enroll in this clinical investigation?

"Acceptance into this trial is contingent upon participants having a metabolic disorder and being between 18 to 40 years old. Currently, the project requires 46 enrollees."

Answered by AI

Is it possible to join the clinical trial currently?

"As per the clinicaltrials.gov page, this experiment was initially announced on March 1st 2021 and has recently undergone a refresh on September 7th 2022. At present, it is recruiting participants for its trials."

Answered by AI

Who else is applying?

What state do they live in?
Michigan
What site did they apply to?
University of Michigan
What portion of applicants met pre-screening criteria?
Did not meet criteria
Met criteria
How many prior treatments have patients received?
0

Why did patients apply to this trial?

Difficult to lose weight. Pre-diabetic and borderline high blood pressure.
PatientReceived 1 prior treatment
Recent research and studies
clinicaltrials.govStudy
Exercise Effects on Adipose Tissue Structure and Function
Jeffrey F Horowitz 2021. "Exercise Effects on Adipose Tissue Structure and Function". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT04812314.
All > Weight Gain > Weight Loss
~17 spots leftby Mar 2026
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