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Exercise for Obesity Management (LG Trial)

N/A
Recruiting
Led By Jeffrey F Horowitz, PhD
Research Sponsored by University of Michigan
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Women must have regularly occurring menses and must be premenopausal
Age: 18-40
Must not have
Women must not be pregnant or actively lactating
Evidence/history of cardiovascular or metabolic disease
Timeline
Screening 3 weeks
Treatment Varies
Follow Up 30 minutes
Awards & highlights

Summary

This trial is testing whether exercise helps people keep weight off after they lose it.

Who is the study for?
This trial is for adults aged 18-40 with a BMI of 27-45 who haven't been exercising regularly. Women should have regular menstrual cycles and not be pregnant or breastfeeding. People can't join if they've had heart or metabolic diseases, take meds affecting metabolism, had recent weight fluctuations, or use tobacco products.Check my eligibility
What is being tested?
The study is testing the impact of exercise on body fat and how it functions after weight loss. Participants will either follow an exercise program or no exercise while losing and then regaining weight. Their metabolic health will be tested before and after these changes.See study design
What are the potential side effects?
Since this trial involves standard physical activity as the intervention, side effects may include typical exercise-related issues such as muscle soreness, fatigue, or injury. The high-calorie diet phase could potentially lead to temporary weight gain.

Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below
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I am a woman who has regular menstrual cycles and am not in menopause.
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I am between 18 and 40 years old.

Exclusion Criteria

You may be eligible for the trial if you check “No” for criteria below:
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I am not pregnant or breastfeeding.
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I have a history of heart or metabolic disease.

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~30 minutes
This trial's timeline: 3 weeks for screening, Varies for treatment, and 30 minutes for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Adipose Capillarization
Adipose Tissue Fibrosis
Fat Cell Size
+2 more
Secondary outcome measures
Blood Lipid Profile
Blood Pressure

Trial Design

2Treatment groups
Experimental Treatment
Group I: No exerciseExperimental Treatment1 Intervention
Subjects assigned to this group are to remain sedentary (no planned physical exercise) throughout the duration of the study.
Group II: ExerciseExperimental Treatment1 Intervention
This exercise prescription represents a common or "conventional" form of physical activity (e.g., moderate/brisk walking). If assigned to this group, participants will perform 45 minutes of moderate intensity continuous steady-state exercise at 70% maximal heart rate (HRmax) to expend 250 calories 4 days per week.
Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
No exercise
2021
N/A
~550
Exercise
2016
Completed Phase 1
~760

Find a Location

Who is running the clinical trial?

University of MichiganLead Sponsor
1,817 Previous Clinical Trials
6,387,316 Total Patients Enrolled
13 Trials studying Weight Loss
6,127 Patients Enrolled for Weight Loss
Jeffrey F Horowitz, PhDPrincipal Investigator - University of Michigan, School of Kinesiology
University of Michigan
2 Previous Clinical Trials
65 Total Patients Enrolled

Media Library

Exercise Clinical Trial Eligibility Overview. Trial Name: NCT04812314 — N/A
Weight Loss Research Study Groups: Exercise, No exercise
Weight Loss Clinical Trial 2023: Exercise Highlights & Side Effects. Trial Name: NCT04812314 — N/A
Exercise 2023 Treatment Timeline for Medical Study. Trial Name: NCT04812314 — N/A
Weight Loss Patient Testimony for trial: Trial Name: NCT04812314 — N/A
~15 spots leftby Mar 2026
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