Exercise for Weight Loss

Phase-Based Estimates
University of Michigan, Ann Arbor, MI
Weight Loss+6 More
Exercise - Behavioral
18 - 65
All Sexes
Eligible conditions
Weight Loss

Study Summary

This study is evaluating whether exercise can help individuals lose weight and keep it off.

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Eligible Conditions

  • Weight Loss
  • Metabolic Diseases
  • Metabolic Syndrome
  • Insulin Resistance
  • Obesity
  • Body Weight
  • Weight Gain

Treatment Effectiveness

Study Objectives

This trial is evaluating whether Exercise will improve 5 primary outcomes and 2 secondary outcomes in patients with Weight Loss. Measurement will happen over the course of 2 hours.

10 minutes
Blood Pressure
15 minutes
Blood Lipid Profile
2 hours
Oral Glucose Tolerance Test (OGTT)
3 minutes
Fat Cell Size
30 minutes
Adipose Capillarization
Adipose Tissue Fibrosis
Muscle Capillarization

Trial Safety

Trial Design

2 Treatment Groups

No Control Group
No exercise

This trial requires 46 total participants across 2 different treatment groups

This trial involves 2 different treatments. Exercise is the primary treatment being studied. Participants will be divided into 2 treatment groups. There is no placebo group. The treatments being tested are not being studied for commercial purposes.

No exercise
Subjects assigned to this group are to remain sedentary (no planned physical exercise) throughout the duration of the study.
This exercise prescription represents a common or "conventional" form of physical activity (e.g., moderate/brisk walking). If assigned to this group, participants will perform 45 minutes of moderate intensity continuous steady-state exercise at 70% maximal heart rate (HRmax) to expend 250 calories 4 days per week.
First Studied
Drug Approval Stage
How many patients have taken this drug
Completed Phase 1
No exercise

Trial Logistics

Trial Timeline

Approximate Timeline
Screening: ~3 weeks
Treatment: Varies
Reporting: 30 minutes
This trial has the following approximate timeline: 3 weeks for initial screening, variable treatment timelines, and roughly 30 minutes for reporting.

Who is running the study

Principal Investigator
J. F. H.
Prof. Jeffrey F Horowitz, professor of Movement Science and director of the Substrate Metabolism Laboratory (SML) at the University of Michigan School of Kinesiology
University of Michigan

Closest Location

University of Michigan - Ann Arbor, MI

Eligibility Criteria

This trial is for patients born any sex between 18 and 65 years old. There are 4 eligibility criteria to participate in this trial as listed below.

Mark “yes” if the following statements are true for you:
No regularly planned exercise/physical activity for at least 6 months
Women must have regularly occurring menses and must be premenopausal
Age: 18-40
Body Mass Index: 30-45 kg/m2

Patient Q&A Section

Please Note: These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Can weight loss be cured?

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Weight loss is a difficult goal to achieve, but its main aim is to improve the general health of the patient. On the medical plane of consideration, it is not an entirely accurate statement to say that a sustained weight loss is permanently erased. Although sustained weight loss can lead to a long remission, it does not guarantee the permanent eradication of a particular medical disease. Thus, physicians and patients are advised to take the long-term consequences of weight loss into consideration when choosing the best path to take to achieve an improved general medical state.

Unverified Answer

What causes weight loss?

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While lifestyle changes are the main determinants for weight loss in overweight adults, weight bearing exercise is also an important component of weight loss programs and should be included as part of lifestyle modification programs.

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What are common treatments for weight loss?

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For short-term weight loss, popular dietary choices do not have a measurable effect on weight loss, while for long-term weight loss medications are more effective.

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What is weight loss?

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Less than 20% of obese people lose weight, whereas about 40% of under-weight people gain weight. Those who lost a significant amount of weight (more than 10 lb or 4.5 kg) decreased 1.3% of their body weight, whereas gaining weight increased 2.3% of their body weight. Weight loss may be particularly important as a treatment for some comorbidities.

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What are the signs of weight loss?

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The most common weight loss symptom is weight loss. Fat-free mass is less affected than fat mass by weight loss. There was no difference in body fat composition between obese men, women, Caucasian or African American children. Obesity does not appear to be associated with more severe weight loss.

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How many people get weight loss a year in the United States?

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Over one in 3 of the obese (39% of those who were at least 20% more body mass index) may lose weight a year. However, only around 15% of those who lose 20% have lost 20% or more of their prepubertal body weight. More than one in three people with a BMI<30 kg/m2 will lose at least 5% body mass over the year.

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What is exercise?

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Running improves cardiac function and cardiovascular fitness and is a valuable tool in weight loss. I am sure that more people than I am able to say is already exercising. As our cities get bigger and more people are exercising indoors (as we do in Pakistan), the need is more urgent for this form of exercise also. Running, cycling and walking may be effective forms of exercise in a weight-loss program, but further studies are needed to validate this.

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What is the primary cause of weight loss?

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The primary cause of weight loss is calorie restriction. The reasons people are so eager to buy weight reduction supplements are understandable. But only a select few are more motivated than the typical person. These are not necessarily the ones who would be expected to get the biggest benefit from these supplements. Most people would want to lose weight, but they would also want to lose a little bit of fat, to improve their looks... The weight loss process is as simple as that, but most would like to try something that would give them a better look. Once they find what makes the best results, I will write more, and share my observations and experience with readers.

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What does exercise usually treat?

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These data suggest that at least one form of exercise may be helpful for the management of obesity. Moderate intensity (for example, brisk cycling) appears to be beneficial for the management of obesity.

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How does exercise work?

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Exercise has many impacts on the body; both physically enhancing muscle growth, as well as reducing body mass. It is not simply a matter of time.

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How serious can weight loss be?

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The amount of weight lost without a healthy lifestyle can be life threatening. However, the risk of life-threatening weight loss was not increased with excessive calorie restriction or weight loss from an unhealthy diet.

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Have there been other clinical trials involving exercise?

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Findings from a recent study of our study are comparable to two exercise studies. It appears that a trial comparing resistance training with a healthy diet might be more fruitful than a trial involving a structured exercise program. When patients receive the right treatment, they can expect to lose weight rapidly, safely and without significant side-effects.

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