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Chemotherapy for Multiple Myeloma
Study Summary
This trial is testing a new lower-dose, shorter-cycle chemotherapy regimen to see if it can help people with high-risk myeloma achieve longer remissions and improved survival.
Eligibility Criteria
Inclusion Criteria
You may be eligible if you check “Yes” for the criteria belowTimeline
Treatment Details
Study Objectives
Outcome measures can provide a clearer picture of what you can expect from a treatment.Trial Design
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Who is running the clinical trial?
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- I haven't had cancer before, except for certain skin cancers or cervical cancer that's been treated.I have had no or just one round of treatment for my multiple myeloma, not counting bone treatments or spot radiation.My lung function tests are at least half of what is expected, or I have an exception due to my condition.I am between 18 and 75 years old.You need to have a certain level of heart function, as measured by a heart imaging test.My condition is not considered high-risk.My kidney function is good, with a creatinine level below 3 mg/dL.You have a high-risk form of the disease, as determined by specific test results or symptoms.My health conditions are well-managed and won't affect my treatment.Your platelet count should be at least 50,000 per microliter of blood, unless your doctor can explain that lower levels are caused by a specific condition in your bone marrow.I have newly diagnosed active multiple myeloma needing treatment.
- Group 1: MEL--VTD-PACE
- Approved for 60 Other Conditions - This treatment demonstrated efficacy for 60 other conditions.
- No Placebo-Only Group - All patients enrolled in this study will receive some form of active treatment.
- All Individual Drugs Already Approved - Therapies where all constituent drugs have already been approved are likely to have better-understood side effect profiles.
- Screening: It may take up to 3 Weeks to process to see if you qualify in this trial.
- Treatment: The duration you will receive the treatment varies.
- Follow Ups: You may be asked to continue sharing information regarding the trial for 6 Months after you stop receiving the treatment.
Frequently Asked Questions
Could you please summarize the risks associated with Cisplatin?
"Cisplatin is a Phase 2 medication, which suggests that while there is some evidence of safety, there is none for efficacy."
Does this research involve elderly individuals?
"According to the screening process for this clinical trial, the age range of patients that can be enrolled starts at 18 and ends when the patient turns 75."
Does this research break new ground in the medical field?
"There are currently 2286 active clinical trials for Cisplatin around the world. The first trial was conducted in 1997 and involved 300 participants. 3741 trials have been completed since then."
How many study subjects are you working with currently?
"Unfortunately, this study has already wrapped up recruitment. The trial was initially posted on October 1st, 2008 and was last updated September 2nd, 2022. However, there are 827 other trials for patients with multiple myeloma and 2286 clinical trials involving Cisplatin that are actively recruiting participants."
Can new patients enroll in this clinical trial at this time?
"Unfortunately, this trial is no longer recruiting patients. The listing was created on October 1st, 2008 and last updated September 2nd, 2022. There are 827 other trials for multiple myeloma and 2286 Cisplatin clinical trials that are currently looking for participants."
Who meets the requirements to participate in this research project?
"This clinical trial is looking for 90 participants that have a multiple myeloma diagnosis and are between 18-75 years old. To be eligible, patients must: have newly diagnosed active MM that requires treatment, cannot have had more than one cycle of systemic MM therapy (excluding bisphosphonates and localized radiation), GEP risk score must be > or = 0.66 or LDH must be > or = 360 U/L, Zubrod < or = 2, platelet count must be > or = 50,000/uL, ejection fraction by ECHO or MUGA scan > or = 45%, adequate pulmonary"
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