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Exercise for Fat Tissue Health

N/A

Recruiting

Led By Hawley Kunz, PhD

Research Sponsored by Mayo Clinic

Eligibility Criteria Checklist

Specific guidelines that determine who can or cannot participate in a clinical trial

Must have

Sedentary men and women

Normal weight (BMI 18.5-28 kg/m^2) older adults

Timeline

Screening 3 weeks

Treatment Varies

Follow Up pre-exercise, immediately post-exercise, and 3 hours after exercise

Awards & highlights

Study Summary

This trial studies how exercise affects fat tissue and how this can improve health in aging and obesity.

Who is the study for?

This trial is for sedentary adults who are either normal weight or obese. It includes older adults (65-85 years) and young adults (18-35 years). Participants should not be active smokers, heavy drinkers, pregnant, or have chronic diseases that could interfere with the study.Check my eligibility

What is being tested?

The study is looking at how exercise affects fat tissue in both aging and obesity. Participants will undergo an exercise regimen and have their adipose tissue biopsied to see the changes that occur due to physical activity.See study design

What are the potential side effects?

While there's no mention of side effects from exercising or biopsy in the provided information, general risks may include muscle soreness from exercise and discomfort or bruising at the biopsy site.

Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below

Select...

I lead a mostly inactive lifestyle.

Select...

I am an older adult with a BMI between 18.5 and 28.

Timeline

Screening ~ 3 weeks3 visits

Treatment ~ Varies

Follow Up ~ pre-exercise, immediately post-exercise, and 3 hours after exercise

Screening ~ 3 weeks

Treatment ~ Varies

Follow Up ~pre-exercise, immediately post-exercise, and 3 hours after exercise

This trial's timeline: 3 weeks for screening, Varies for treatment, and pre-exercise, immediately post-exercise, and 3 hours after exercise for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.

Primary outcome measures

Adipose Immune Cell Populations

Adipose tissue gene expression of adhesion G-protein coupled receptor E (ADGRE) measured by PCR.

Adipose tissue gene expression of adiponectin (ADIPOQ) measured by PCR.

+13 more

Secondary outcome measures

Adipocyte cell size

Plasma inflammatory cytokine concentrations measured using the Olink Target Inflammation Panel (includes 96 inflammation-associated proteins)

Protein cargo of plasma extracellular vesicles measured using mass spectrometry extracellular vesicles

Other outcome measures

Body fat percentage

Cardiorespiratory Fitness

Fasting plasma glucose

+3 more

Trial Design

4Treatment groups

Experimental Treatment

Group I: Young adults without obesityExperimental Treatment2 Interventions

Participants with a BMI between 18.5 and 28 and aged 18-35 years will have an adipose tissue biopsy taken from the abdomen before and after exercise.

Group II: Young adults with obesityExperimental Treatment2 Interventions

Participants with a BMI between 30 and 40 and aged 18-35 years will have an adipose tissue biopsy taken from the abdomen before and after exercise.

Group III: Older adults without obesityExperimental Treatment2 Interventions

Participants with a BMI between 18.5 and 28 and aged 65-85 years will have an adipose tissue biopsy taken from the abdomen before and after exercise.

Group IV: Older adults with obesityExperimental Treatment2 Interventions

Participants with a body mass index (BMI) between 30 and 40 and aged 65-85 years will have an adipose tissue biopsy taken from the abdomen before and after exercise.

Treatment

First Studied

Drug Approval Stage

How many patients have taken this drug

Adipose Tissue Biopsy

2015

N/A

~120

Exercise

2016

Completed Phase 1

~760

0 / 2Eligibility criteria met

Find a Location

Who is running the clinical trial?

Mayo ClinicLead Sponsor

3,216 Previous Clinical Trials

3,767,428 Total Patients Enrolled

National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)NIH

2,359 Previous Clinical Trials

4,314,532 Total Patients Enrolled

Hawley Kunz, PhDPrincipal InvestigatorMayo Clinic

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Am I eligible to contribute to this clinical research?

"Candidates should have robust health and be between the ages of 18-85 to qualify for this clinical trial, which is seeking roughly 60 participants."

Answered by AI

Does this investigation accept participants who are below 65 years of age?

"This trial has an age range requirement of 18 to 85 years old. For those under the legal age, 247 studies are available and 1029 for elderly patients."

Answered by AI

Are there still opportunities to participate in this investigation?

"According to clinicaltrials.gov, this trial is not presently recruiting patients; it was first posted on September 1st 2023 and most recently edited on the 19th of that same month. Despite their lack of recruitment, there are still 1821 other studies searching for participants right now."

Answered by AI

Recent research and studies

clinicaltrials.govStudy

A Study of Adipose Tissue in Adaptive Responses to Exercise

Hawley E. Kunz 2023. "A Study of Adipose Tissue in Adaptive Responses to Exercise". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT06053125.