60 Participants Needed

Exercise for Fat Tissue Health

RD
HK
RM
RP
Overseen ByRachel Passehl
Age: 18+
Sex: Any
Trial Phase: Academic
Sponsor: Mayo Clinic
No Placebo GroupAll trial participants will receive the active study treatment (no placebo)

What You Need to Know Before You Apply

What is the purpose of this trial?

The purpose of this research is to determine how exercise affects fat (adipose) tissue and how changes to adipose tissue that occur during and after exercise might improve health in aging and obesity.

Will I have to stop taking my current medications?

The trial requires that you do not use medications known to influence the main outcomes of the study. It's best to discuss your current medications with the study team to see if they are allowed.

Is it safe to participate in a clinical trial involving adipose tissue biopsy and exercise?

Adipose tissue biopsies, when performed using a mini-liposuction technique or a non-diathermy surgical method, are generally safe with minimal side effects. Participants can resume most everyday activities shortly after the procedure, although they should avoid swimming and strenuous activities for 48 hours to prevent excessive bleeding.12345

How does exercise as a treatment for fat tissue health differ from other treatments?

Exercise is unique because it not only helps reduce fat mass but also improves the function of fat tissue by enhancing blood flow and fat mobilization, directing fatty acids to muscles instead of storing them. Unlike other treatments that might focus solely on reducing fat, exercise also contributes to overall metabolic health through these dynamic changes in fat tissue.678910

What data supports the effectiveness of the treatment involving exercise and adipose tissue biopsy for fat tissue health?

Research shows that exercise can reduce abdominal fat and improve metabolic health, which may help in treating conditions related to excess fat tissue. Exercise is known to increase insulin sensitivity and improve blood lipid profiles, making it a useful non-drug treatment for managing fat tissue health.911121314

Who Is on the Research Team?

HK

Hawley Kunz, PhD

Principal Investigator

Mayo Clinic

Are You a Good Fit for This Trial?

This trial is for sedentary adults who are either normal weight or obese. It includes older adults (65-85 years) and young adults (18-35 years). Participants should not be active smokers, heavy drinkers, pregnant, or have chronic diseases that could interfere with the study.

Inclusion Criteria

I lead a mostly inactive lifestyle.
I am a young adult with a normal weight.
I am an older adult with a BMI between 18.5 and 28.
See 2 more

Exclusion Criteria

Participation in ≥ 30 minutes of structured physical activity ≥ 2 days per week
You currently smoke or use tobacco products.
You have a history of alcohol or drug abuse.
See 10 more

Timeline for a Trial Participant

Screening

Participants are screened for eligibility to participate in the trial

2-4 weeks

Baseline Assessment

Baseline measurements including HbA1c, white blood count, body fat percentage, cardiorespiratory fitness, fasting plasma insulin, and fasting plasma glucose are taken

1 week
1 visit (in-person)

Exercise Intervention

Participants undergo a 30-minute bout of cycling exercise at 70% of VO2max. Adipose tissue biopsies and various measurements are taken pre-exercise, immediately post-exercise, and 3 hours post-exercise

1 day
1 visit (in-person)

Follow-up

Participants are monitored for changes in adipose tissue and systemic responses post-exercise

4 weeks

What Are the Treatments Tested in This Trial?

Interventions

  • Adipose Tissue Biopsy
  • Exercise
Trial Overview The study is looking at how exercise affects fat tissue in both aging and obesity. Participants will undergo an exercise regimen and have their adipose tissue biopsied to see the changes that occur due to physical activity.
How Is the Trial Designed?
4Treatment groups
Experimental Treatment
Group I: Young adults without obesityExperimental Treatment2 Interventions
Participants with obesity as determined by the principal investigator and aged 18-35 years will have an adipose tissue biopsy taken from the abdomen before and after exercise.
Group II: Young adults with obesityExperimental Treatment2 Interventions
Participants with obesity as determined by the principal investigator and aged 18-35 years will have an adipose tissue biopsy taken from the abdomen before and after exercise.
Group III: Older adults without obesityExperimental Treatment2 Interventions
Participants with obesity as determined by the principal investigator and aged 65-85 years will have an adipose tissue biopsy taken from the abdomen before and after exercise.
Group IV: Older adults with obesityExperimental Treatment2 Interventions
Participants with obesity as determined by the principal investigator and aged 65-85 years will have an adipose tissue biopsy taken from the abdomen before and after exercise.

Find a Clinic Near You

Who Is Running the Clinical Trial?

Mayo Clinic

Lead Sponsor

Trials
3,427
Recruited
3,221,000+

National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)

Collaborator

Trials
2,513
Recruited
4,366,000+

Published Research Related to This Trial

Physical activity plays a crucial role in treating obesity not just by reducing overall body weight or fat mass, but also by targeting harmful fat deposits in the abdomen, liver, and muscle, which are linked to obesity-related health risks.
This review emphasizes that physical activity can be beneficial for obesity treatment even when there is minimal or no weight loss, highlighting its importance beyond just weight management.
Physical activity in the treatment of obesity: beyond body weight reduction.Janiszewski, PM., Ross, R.[2016]
A systematic review of 27 trials (19 randomized controlled trials and 8 non-randomized) found that physical activity can significantly reduce abdominal and visceral fat in overweight or obese individuals, even without changes in overall body weight or waist circumference.
Imaging techniques were crucial in measuring these fat changes, but the review highlighted the need for more rigorous studies to confirm the benefits of exercise on abdominal fat reduction.
The influence of physical activity on abdominal fat: a systematic review of the literature.Kay, SJ., Fiatarone Singh, MA.[2018]
In a study of 152 participants over 24 weeks, higher amounts and intensities of exercise led to a greater proportion of individuals achieving significant reductions in visceral adipose tissue (AT) compared to a control group.
Clinically meaningful reductions in waist circumference or body weight were found to predict significant reductions in abdominal adiposity, with 76% to 93% of those achieving these changes also showing meaningful reductions in visceral AT.
Individual Response to Standardized Exercise: Total and Abdominal Adipose Tissue.Brennan, AM., Day, AG., Cowan, TE., et al.[2021]

Citations

Physical activity in the treatment of obesity: beyond body weight reduction. [2016]
The influence of physical activity on abdominal fat: a systematic review of the literature. [2018]
Individual Response to Standardized Exercise: Total and Abdominal Adipose Tissue. [2021]
Individual Response to Standardized Exercise: Total and Abdominal Adipose Tissue. [2019]
Effects of exercise training on abdominal obesity and related metabolic complications. [2018]
Human Subcutaneous Adipose Tissue Sampling using a Mini-liposuction Technique. [2021]
A Technique for Subcutaneous Abdominal Adipose Tissue Biopsy via a Non-diathermy Method. [2019]
Optimizing adipose tissue extract isolation with stirred suspension culture. [2020]
The mechanisms involved in the increased adiposity induced by interruption of regular physical exercise practice. [2019]
10.United Statespubmed.ncbi.nlm.nih.gov
Percutaneous adipose tissue biopsy by mini-liposuction for metabolic studies. [2017]
Exercise and ectopic fat in type 2 diabetes: A systematic review and meta-analysis. [2018]
12.United Statespubmed.ncbi.nlm.nih.gov
Physical activity and exercise in the regulation of human adipose tissue physiology. [2022]
Effect of exercise on abdominal fat loss in men and women with and without type 2 diabetes. [2021]
Remodeling of white adipose tissue metabolism by physical training prevents insulin resistance. [2014]
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