Exercise for Fat Tissue Health
What You Need to Know Before You Apply
What is the purpose of this trial?
The purpose of this research is to determine how exercise affects fat (adipose) tissue and how changes to adipose tissue that occur during and after exercise might improve health in aging and obesity.
Will I have to stop taking my current medications?
The trial requires that you do not use medications known to influence the main outcomes of the study. It's best to discuss your current medications with the study team to see if they are allowed.
Is it safe to participate in a clinical trial involving adipose tissue biopsy and exercise?
Adipose tissue biopsies, when performed using a mini-liposuction technique or a non-diathermy surgical method, are generally safe with minimal side effects. Participants can resume most everyday activities shortly after the procedure, although they should avoid swimming and strenuous activities for 48 hours to prevent excessive bleeding.12345
How does exercise as a treatment for fat tissue health differ from other treatments?
Exercise is unique because it not only helps reduce fat mass but also improves the function of fat tissue by enhancing blood flow and fat mobilization, directing fatty acids to muscles instead of storing them. Unlike other treatments that might focus solely on reducing fat, exercise also contributes to overall metabolic health through these dynamic changes in fat tissue.678910
What data supports the effectiveness of the treatment involving exercise and adipose tissue biopsy for fat tissue health?
Research shows that exercise can reduce abdominal fat and improve metabolic health, which may help in treating conditions related to excess fat tissue. Exercise is known to increase insulin sensitivity and improve blood lipid profiles, making it a useful non-drug treatment for managing fat tissue health.911121314
Who Is on the Research Team?
Hawley Kunz, PhD
Principal Investigator
Mayo Clinic
Are You a Good Fit for This Trial?
This trial is for sedentary adults who are either normal weight or obese. It includes older adults (65-85 years) and young adults (18-35 years). Participants should not be active smokers, heavy drinkers, pregnant, or have chronic diseases that could interfere with the study.Inclusion Criteria
Exclusion Criteria
Timeline for a Trial Participant
Screening
Participants are screened for eligibility to participate in the trial
Baseline Assessment
Baseline measurements including HbA1c, white blood count, body fat percentage, cardiorespiratory fitness, fasting plasma insulin, and fasting plasma glucose are taken
Exercise Intervention
Participants undergo a 30-minute bout of cycling exercise at 70% of VO2max. Adipose tissue biopsies and various measurements are taken pre-exercise, immediately post-exercise, and 3 hours post-exercise
Follow-up
Participants are monitored for changes in adipose tissue and systemic responses post-exercise
What Are the Treatments Tested in This Trial?
Interventions
- Adipose Tissue Biopsy
- Exercise
Find a Clinic Near You
Who Is Running the Clinical Trial?
Mayo Clinic
Lead Sponsor
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Collaborator