Browse 64 Medulloblastoma Medical Studies Across 158 Cities
5 Phase 3 Trial · 1888 Medulloblastoma Clinics
What Are Medulloblastoma Clinical Trials?
Medulloblastoma is a pediatric (cancerous) brain tumor. The condition is progressive and fast-growing. Hence, it is categorized as a Grade IV tumor. It begins from the cerebellum (responsible for controlling complex cognitive and motor functions) and spreads fast to other body parts. Symptoms include problems with walking and maintaining balance. However, if a Medulloblastoma tumor blocks the CSF, it can put pressure on the skull. This problem is characterized by headaches, vomiting, extreme sleepiness, and blurred vision. When Medulloblastoma spreads to the spine, the symptoms are spinal pain and a change in bladder habits.
Medulloblastoma clinical trials are studies performed to identify the best treatments, efficacy, and safety. These studies help understand the effects of Medulloblastoma on people and how it impacts their quality of life.
Why Is Medulloblastoma Being Studied Through Clinical Trials?
Statistics show that approximately 500 children in the United States are diagnosed with this condition each year. However, only 200 adults in the US are diagnosed each year with Medulloblastoma. Furthermore, the condition only represents 1 percent of all cancerous brain tumors. It predominantly affects children and younger adults between 20 and 40 years.
The exact cause of Medulloblastoma is unknown. However, research shows that a small percentage of Medulloblastoma that occurs in childhood may be linked to changes in the gene. Therefore, Medulloblastoma clinical trials are still underway. The condition is being studied through trials to determine the actual cause of the brain tumor, which may be the best treatment to cure, prevent and treat Medulloblastoma in children and adults with minimal pain and the best outcomes.
What Are the Types of Treatments Available for Medulloblastoma?
People with Medulloblastoma may have to undergo surgery. Surgery may be carried out to relieve fluid buildup or remove Medulloblastoma. The type of surgery is determined by age, patient's health, tumor subtype, extent, and tumor grade. If the Medulloblastoma blocks the flow of CSF (cerebrospinal fluid), surgery is required to ensure the smooth flow of fluid to the brain.
Likewise, removing Medulloblastoma may be needed if it develops deep inside. However, sometimes complete removal of Medulloblastoma isn't possible if the tumor is near the critical structures in the brain. Therefore, surgery is accompanied by radiation and chemotherapy.
What Are Some Recent Breakthrough Clinical Trials for Medulloblastoma?
1990: The treatment of Medulloblastoma. Results of a prospective randomized trial- The trial studied the effectiveness of chemotherapy after surgery and radiation therapy. Two hundred thirty-three patients participated in the trial. They were randomly assigned radiation with or without chemotherapy. The study concluded that patients with advanced stages of Medulloblastoma benefited more from the chemotherapy than those in low stages.
2022: A Phase 1 Trial of TB-403 in Relapsed Medulloblastoma-The study focused on TB-403 (a monoclonal antibody) that blocks PIGF (placental growth factor), inhibiting the growth of the tumor. This research concluded that TB-403 is both well-tolerated and safe at all doses. Hence, more research is being carried out to determine the efficacy of Medulloblastoma.
Who Are Some Key Opinion Leaders / Researchers / Institutions Conducting Medulloblastoma Clinical Trial Research?
This program by the Children's National organization is focused on developing a solid understanding of the causative mechanism to improve Medulloblastoma treatment.
It is an organization dedicated to providing cures for cancer in children through innovative treatment approaches and research.