Reviewed by Michael Gill, B. Sc.
25 Medulloblastoma Clinical Trials Near Me
Top Hospitals for Medulloblastoma Clinical Trials
Top Cities for Medulloblastoma Clinical Trials
Image of Saint Louis in Missouri.
Saint Louis
54Active Trials
Washington University School of MedicineTop Active Site
Medulloblastoma Clinical Trials by Phase of Trial
Phase < 1 Medulloblastoma Clinical Trials
3Active Medulloblastoma Clinical Trials
3Number of Unique Treatments
21Number of Active Locations
Medulloblastoma Clinical Trials by Age Group
Most Recent Medulloblastoma Clinical Trials
Top Treatments for Medulloblastoma Clinical Trials
Treatment Name
Active Medulloblastoma Clinical Trials
All Time Trials for Medulloblastoma
First Recorded Medulloblastoma Trial
Cyclophosphamide
3
16
2001
Cisplatin
3
10
2001
Palbociclib
2
3
2017
Pharmacological Study
2
9
2009
PEP-CMV
2
2
2018
Recently Completed Studies with FDA Approved Treatments for Medulloblastoma
Treatment
Year
Sponsor
Nivolumab
2021
Bristol-Myers Squibb

What Are Medulloblastoma Clinical Trials?

Medulloblastoma is a pediatric (cancerous) brain tumor. The condition is progressive and fast-growing. Hence, it is categorized as a Grade IV tumor. It begins from the cerebellum (responsible for controlling complex cognitive and motor functions) and spreads fast to other body parts. Symptoms include problems with walking and maintaining balance. However, if a Medulloblastoma tumor blocks the CSF, it can put pressure on the skull. This problem is characterized by headaches, vomiting, extreme sleepiness, and blurred vision. When Medulloblastoma spreads to the spine, the symptoms are spinal pain and a change in bladder habits.

Medulloblastoma clinical trials are studies performed to identify the best treatments, efficacy, and safety. These studies help understand the effects of Medulloblastoma on people and how it impacts their quality of life.

Why Is Medulloblastoma Being Studied Through Clinical Trials?

Statistics show that approximately 500 children in the United States are diagnosed with this condition each year. However, only 200 adults in the US are diagnosed each year with Medulloblastoma. Furthermore, the condition only represents 1 percent of all cancerous brain tumors. It predominantly affects children and younger adults between 20 and 40 years.

The exact cause of Medulloblastoma is unknown. However, research shows that a small percentage of Medulloblastoma that occurs in childhood may be linked to changes in the gene. Therefore, Medulloblastoma clinical trials are still underway. The condition is being studied through trials to determine the actual cause of the brain tumor, which may be the best treatment to cure, prevent and treat Medulloblastoma in children and adults with minimal pain and the best outcomes.

What Are the Types of Treatments Available for Medulloblastoma?

People with Medulloblastoma may have to undergo surgery. Surgery may be carried out to relieve fluid buildup or remove Medulloblastoma. The type of surgery is determined by age, patient's health, tumor subtype, extent, and tumor grade. If the Medulloblastoma blocks the flow of CSF (cerebrospinal fluid), surgery is required to ensure the smooth flow of fluid to the brain.

Likewise, removing Medulloblastoma may be needed if it develops deep inside. However, sometimes complete removal of Medulloblastoma isn't possible if the tumor is near the critical structures in the brain. Therefore, surgery is accompanied by radiation and chemotherapy.

What Are Some Recent Breakthrough Clinical Trials for Medulloblastoma?

1990: The treatment of Medulloblastoma. Results of a prospective randomized trial- The trial studied the effectiveness of chemotherapy after surgery and radiation therapy. Two hundred thirty-three patients participated in the trial. They were randomly assigned radiation with or without chemotherapy. The study concluded that patients with advanced stages of Medulloblastoma benefited more from the chemotherapy than those in low stages.

2022: A Phase 1 Trial of TB-403 in Relapsed Medulloblastoma-The study focused on TB-403 (a monoclonal antibody) that blocks PIGF (placental growth factor), inhibiting the growth of the tumor. This research concluded that TB-403 is both well-tolerated and safe at all doses. Hence, more research is being carried out to determine the efficacy of Medulloblastoma.

Who Are Some Key Opinion Leaders / Researchers / Institutions Conducting Medulloblastoma Clinical Trial Research?

Neuro-Oncology Research

This program by the Children's National organization is focused on developing a solid understanding of the causative mechanism to improve Medulloblastoma treatment. 

Emily Whitehead Foundation

It is an organization dedicated to providing cures for cancer in children through innovative treatment approaches and research.

About The Author

Michael Gill preview

Michael Gill - B. Sc.

First Published: October 11th, 2021

Last Reviewed: November 14th, 2022

Michael Gill holds a Bachelors of Science in Integrated Science and Mathematics from McMaster University. During his degree he devoted considerable time modeling the pharmacodynamics of promising drug candidates. Since then, he has leveraged this knowledge of the investigational new drug ecosystem to help his father navigate clinical trials for multiple myeloma, an experience which prompted him to co-found Power Life Sciences: a company that helps patients access randomized controlled trials.