Mesothelioma Clinical Trials 2022

Mesothelioma studies recruiting patients for novel treatments. Filter by phase, distance, and inclusion criteria to find your perfect mesothelioma clinical trial in 2022.

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Study of NGM438 as Monotherapy and in Combination with Pembrolizumab in Advanced or Metastatic Solid Tumors

This is a Phase 1/2, open-label, multicenter, study of the safety, tolerability, PK, PD, and anti-tumor activity of MRTX1719 patients with advanced, unresectable or metastatic solid tumor malignancy with homozygous deletion of the MTAP gene.

NGM831 plus pembrolizumab

Study of NGM831 as Monotherapy and in Combination with Pembrolizumab in Advanced or Metastatic Solid Tumors

This study is about TAK-500, given either alone or with pembrolizumab, in adults with select locally advanced or metastatic solid tumors. The aims of the study are: to assess the safety profile of TAK-500 when given alone and when given with pembrolizumab. to assess the effects of TAK-50…

The purpose of this study is to characterize the safety and tolerability of IAG933 in patients with mesothelioma, NF2/LATS1/LATS2 mutated tumors and tumors with functional YAP/TAZ fusions and to identify the maximum tolerated dose and/or recommended dose.

This study is evaluating whether a drug may help treat pleural mesothelioma and other cancers.

This study is evaluating whether a drug may be safe for use in humans.

This study is evaluating whether a drug may help patients with mesothelioma.

This study is evaluating whether a new supportive care program can help individuals with lung cancer improve their quality of life after cancer treatment is over.

Patients with malignant pleural mesothelioma (MPM) that cannot be surgically removed will receive first-line treatment with standard chemotherapy of cisplatin or carboplatin and pemetrexed. Two-thirds of the participants in the study will be randomly assigned to also receive a new treatmen…

This study is evaluating whether a drug may help treat cancer.

This study is evaluating whether a drug called INCB099318 is safe and well tolerated in people with cancer.

This study is evaluating whether a drug may help treat solid tumors.

This study is evaluating whether a combination of two immunotherapy drugs may help treat multiple myeloma.

Gavocabtagene autoleucel (gavo-cel; TC-210) is a novel cell therapy that consists of autologous genetically engineered T cells expressing a single-domain antibody that recognizes human Mesothelin, fused to the CD3-epsilon subunit which, upon expression, is incorporated into the endogenous …

VMD-928 300 mg Tablets or 100 mg Capsules

This study is evaluating whether a drug may help treat cancer.

Pemetrexed and cisplatin

This study is evaluating whether a drug may help treat lung cancer.

This study is evaluating whether bosutinib may be effective in combination with pemetrexed for treating cancer.

This study is evaluating whether INCB001158 is safe and has activity in people with advanced/metastatic solid tumors.

This study is evaluating whether tazemetostat is effective as a single agent.

This study is evaluating whether a new treatment for malignant pleural mesothelioma is safe and effective.

Questionnaires & online virtual support group

This study is evaluating whether mesothelioma affects patients' emotional and physical well-being.

Intensity Modulated Radiation Therapy

This study is evaluating whether a new radiation technique may help treat mesothelioma.

This study is evaluating whether a new drug called Milataxel can be used to treat people with Mesothelioma.

The purpose of this study is to test the safety and tolerability of HFB200301 in patients with advanced cancers. There are two parts in this study. During the escalation part, groups of participants will receive increasing doses until a safe and tolerable dose of HFB200301 is determined. D…

This study is for individuals who have peritoneal mesothelioma, a cancer of the lining of your abdominal wall and organs (the peritoneum). Doctors leading the study would like to determine the effects of treating this cancer with immunotherapy drugs (nivolumab and ipilimumab - the two stud…

This study is evaluating whether a drug called NGM707 can be used to treat cancer.

Background: Mesothelioma is a type of cancer. It originates in cells that line human body cavities. Most people have advanced disease when they are diagnosed. Researchers want to see if a combination of drugs can help. Objective: To find a safe dose of LMB-100 in combination with ipilim…

This study is evaluating whether a drug may help treat cancer.

This is a master prospective Phase I-II trial evaluating feasibility and efficacy of stereotactic magnetic resonance (MR) guided adaptive radiation therapy (SMART) in patients with cancer. The phase 1 study will evaluate the feasibility and safety of delivering SMART in patients with canc…

This study is evaluating whether a combination of two drugs may help treat mesothelioma.

Fludarabine + Cyclophosphamide combination

This study is evaluating whether a new treatment regimen may help individuals with certain types of cancer.

This study is evaluating whether a new method for determining stage and prognosis of individuals with malignant pleural mesothelioma is accurate.

This study is evaluating whether a drug may help treat solid tumors.

This study is evaluating whether a drug called niraparib can be used to treat patients with tumors that have mutations in BAP1 and other DNA damage response genes.

This study is evaluating whether a combination of two drugs can be more effective than one drug alone.

This study is evaluating whether a drug called durvalumab can improve survival for people with pleural mesothelioma.

ADI-PEG 20 plus Pem Cis

This study is evaluating whether a drug which restricts the amount of arginine in the body may help treat mesothelioma.

This study is evaluating whether a drug may help treat advanced solid tumors.

This study is evaluating whether a drug may help treat cancer.

This study is evaluating whether a drug or combination of drugs can improve the immune system in people with mesothelioma.

The purpose of this Phase I study is to test the safety of different doses of specially prepared immune cells (called "T cells") collected from blood. The Investigators want to find a safe dose of these modified T cells for patients who have malignant pleural disease. They want to find out…

The goal of this clinical research study is to learn how dasatinib affects biomarker levels in patients with malignant pleural mesothelioma that may be able to be removed by surgery. The safety and effectiveness of this drug will also be studied. This research study is financially support…

This study is evaluating whether a drug called Onconase plus doxorubicin is more effective than doxorubicin alone in treating patients with malignant mesothelioma.

This study is evaluating whether CPI-0209 may be an effective treatment for cancer.

Mesothelin Expression

Background: The protein mesothelin is found on many kinds of tumors. The drug LMB-100 targets cancer cells that make this protein. Researchers want to see if LMB-100 combined with another drug can help people with these tumors. Objective: To find a safe dose of LMB-100 plus tofacitinib …

This study is evaluating whether a combination of chemotherapy and a drug called pembrolizumab may help treat malignant pleural mesothelioma.

This study is evaluating whether a new drug may help treat cancer.

Light Dosimetry for Intranoperative Therapy

This study is evaluating whether a light dosimetry system can be used to help doctors determine how much light is delivered during photodynamic therapy.

This study is evaluating whether a combination of two drugs may help treat mesothelioma.

Cord Blood-derived Expanded Allogeneic Natural Killer Cells

This study is evaluating whether a combination of cord blood-derived expanded allogeneic natural killer cells and chemotherapy may help treat children and young adults with solid tumors.

This study is evaluating whether a combination of avelumab and radiation therapy is safe and what effect avelumab has on mesothelioma when given in combination with radiation therapy.

Background: Non-small cell lung cancer (NSCLC) is the most common type of lung cancer. Lung cancer is the leading cause of cancer-related death in the United States. Most people with lung cancer are already in the advanced stages of the disease by the time they see a doctor. Researchers w…

Extrapleural Pneumonectomy

This study is evaluating how well atezolizumab, pemetrexed disodium, cisplatin, and surgery with or without radiation therapy works in treating patients with stage I-III pleural malignant mesothelioma.

This study is evaluating whether a combination of two treatments may help treat pleural mesothelioma.

Laboratory Biomarker Analysis

This phase II trial studies how well atezolizumab and bevacizumab work in treating patients with rare solid tumors. Immunotherapy with monoclonal antibodies, such as atezolizumab and bevacizumab, may help the body's immune system attack the cancer, and may interfere with the ability of tum…

This study is evaluating whether a drug may help treat malignant mesothelioma.

This study is evaluating whether a new treatment for mesothelioma may help patients live longer.

This phase II trial studies nivolumab and ipilimumab in treating patients with rare tumors. Immunotherapy with monoclonal antibodies, such as nivolumab and ipilimumab, may help the body's immune system attack the cancer, and may interfere with the ability of tumor cells to grow and spread.…

This is a single institution, single-arm, window of opportunity pilot trial of pembrolizumab in patients with resectable malignant pleural mesothelioma. All patients will undergo a pretreatment PET/CT scan for clinical staging and a VATS procedure to acquire pretreatment tissue. Three cyc…

This study is evaluating whether a drug called IPI-549 can be used to treat cancer.

This study is evaluating whether methoxyamine can be safely given together with cisplatin and pemetrexed disodium to treat patients with solid tumors or mesothelioma that have spread to other places in the body and usually cannot be cured

Autologous tumor infiltrating lymphocytes (TILs)

This study is evaluating whether a treatment for mesothelioma is safe and useful.

This study is evaluating whether a drug called pembrolizumab can help treat people with malignant mesothelioma.

This study is evaluating whether a combination of surgery and a drug which is activated by light may help treat a type of lung cancer.

This study is evaluating whether a drug called tremelimumab can help people with mesothelioma.

This study is evaluating whether a virus can be used to treat a malignant pleural effusion.

This study is evaluating whether a combination of cediranib maleate and pemetrexed disodium and cisplatin is safe and effective in treating patients with malignant pleural mesothelioma.

The SMARTEST trial is a phase II non-blinded randomized trial designed to evaluate the benefit of low dose cyclophosphamide in sequential combination with sub-ablative radiation (Arm A) versus sub-ablative radiation alone (Arm B) before surgery as well as the safety and efficacy of consoli…

Immunohistochemical Assay for Mesothelin

Background: Cancers that spread into the thin tissue lining your lungs (pleura) cause serious illness. They often recur when removed. These tumors include malignant pleural mesothelioma (MPM), caused by exposure to asbestos and related fibers. Malignant pleural effusions (MPEs) are caused…

To test the safety of and effectiveness of XmAb20717 for participants with advanced rare cancers.

This is a first in human study in patients with advanced or metastatic solid tumors known to have an MTAP deletion. The first part of the study is an open-label, dose escalation and the second part is an open label dose expansion in specific MTAP-deleted tumor types. The study drug, TNG908…

This is a Phase 1, first-in-human (FIH) clinical study to evaluate the safety, tolerability, pharmacokinetics (PK), pharmacodynamics (PD), and preliminary antitumor activity of IK-930, an oral TEAD inhibitor, administered orally (PO) as monotherapy in subjects with advanced solid tumors wi…

This study is evaluating whether a combination of pembrolizumab and cryoablation is a safe treatment that causes few or mild side effects in people with mesothelioma. The researchers will also look at whether the combination of pembrolizumab and cryoablation

This study is evaluating whether a new drug can be safely given to people with cancer.

This study is evaluating whether immunotherapy (atezolizumab) plus the usual treatment is better than the usual treatment alone in treating patients with peritoneal mesothelioma.

Stereotactic Body Radiation Therapy

This study is evaluating whether stereotactic body radiation therapy and immunotherapy are safe and effective for treating patients with mesothelioma.

Primary Objective: -To determine the antitumor activity of SAR444245 in combination with other anticancer therapies. Secondary Objectives: To confirm the dose and to assess the safety profile of SAR444245 when combined with other anticancer therapies. To assess other indicators of antit…

This study is evaluating whether a combination of two drugs may be effective for treating malignant pleural mesothelioma.

Heated Intraperitonial Chemotherapy

Background: Cytoreductive surgery (CRS) removes tumors in the abdomen. HIPEC is heated chemotherapy that washes the abdomen. CRS and HIPEC may help people with peritoneal carcinomatosis. These are tumors that have spread to the lining of the abdomen from other cancers. Researchers think t…

This study is evaluating whether a new type of CAR-T cell treatment may be safe for people with a certain type of cancer.

This study is evaluating whether poly-ICLC may help reduce the size of pleural mesothelioma tumors prior to surgery.

This study is evaluating whether heated intra-peritoneal chemotherapy with doxorubicin and cisplatin works for the treatment of abdominal or pelvic tumors that can be removed by surgery (resectable), does not respond to treatment (ref

This study is evaluating whether a combination of two drugs may be more effective than either drug alone.

This study is evaluating whether a combination of drugs may help treat mesothelioma.

This study is evaluating whether the addition of targeted radiation therapy to surgery and the usual chemotherapy treatment works for the treatment of stage I-IIIA malignant pleural mesothelioma.

Varying Doses of Background and Boost RT

This study is evaluating whether a boost radiation dose can be tolerated in patients with malignant pleural mesothelioma.

This study is evaluating whether a virus may help treat malignant pleural mesothelioma.

This study is evaluating whether a drug may help treat tumors with a specific genetic mutation.

This study is evaluating whether a drug may help treat solid tumors.

Velcade (bortezomib) plus Eloxatin (oxaliplatin)

Study chemotherapy will consist of four treatments with Velcade (days 1, 4, 15, and 18) and two treatments with Eloxatin(days 4 and 18). Patients will be undergo standard of care blood work and Quality of Life (QOL) questionnaires at each visit and will be have repeat CT scans performed to…

Pre-op RT +/- chemotherapy

This study is evaluating whether a short course of radiation therapy (RT) can reduce the risk of tumour cells spreading outside the chest cavity during surgery.

SGN-CD228A