Mesothelioma Clinical Trials
Here are the 6 most popular medical studies for mesothelioma
Chemotherapy
APG-5918 for Cancer
This trial will test the safety and effectiveness of a new drug, APG-5918, in people with cancer. The drug will be given orally in 28-day cycles. The trial will have two parts: first, a dose escalation to test safety, and second, a dose expansion to test effectiveness.
Popular filter options for mesothelioma trials
NSCLC Clinical Trials
View 30 NSCLC medical studies.
CAR T-cell Therapy
Gavo-cel for Mesothelioma
This trial is testing a new cell therapy that consists of T cells that have been genetically engineered to express a single-domain antibody that recognizes human Mesothelin. The T cells are fused to the CD3-epsilon subunit, which is incorporated into the endogenous T cell receptor (TCR) complex. The aim of the trial is to establish the recommended Phase 2 dose and to evaluate the efficacy of the therapy in patients with advanced mesothelin-expressing cancers.
Non-Small Cell Lung Cancer Clinical Trials
View 29 Non-Small Cell Lung Cancer medical studies.
CAR T-cell Therapy
Gavo-cel for Mesothelioma
This trial is testing a new cell therapy that consists of T cells that have been genetically engineered to express a single-domain antibody that recognizes human Mesothelin. The T cells are fused to the CD3-epsilon subunit, which is incorporated into the endogenous T cell receptor (TCR) complex. The aim of the trial is to establish the recommended Phase 2 dose and to evaluate the efficacy of the therapy in patients with advanced mesothelin-expressing cancers.
Metastatic Mesothelioma Clinical Trials
View 97 metastatic mesothelioma medical studies.
CAR T-cell Therapy
TIL + Fludarabine + Cyclophosphamide for Advanced Solid Cancers
This trial is testing a new treatment for cancer that involves removing some lymph nodes, infusing the patient with their own tumor cells, and then giving them a high dose of aldesleukin. The goal is to see if this can help patients with locally advanced, recurrent, or metastatic cancer.
PD-L1 Positive Clinical Trials
View 16 PD-L1 positive medical studies.
Chemotherapy
Durvalumab + Tremelimumab with or without Chemotherapy for Mesothelioma
This trial will test if combination chemoimmunotherapy or dual agent immunotherapy alone improve efficacy for mesothelioma patients. It will assess safety & efficacy and explore biomarkers.
PD-1 Positive Clinical Trials
View 13 PD-1 positive medical studies.
Chemotherapy
Durvalumab + Tremelimumab with or without Chemotherapy for Mesothelioma
This trial will test if combination chemoimmunotherapy or dual agent immunotherapy alone improve efficacy for mesothelioma patients. It will assess safety & efficacy and explore biomarkers.
PD-1 Inhibitor
Pembrolizumab for Malignant Mesothelioma
This trial is testing how well pembrolizumab works in treating patients with malignant mesothelioma. Pembrolizumab is a monoclonal antibody that works by blocking PD-1, which may stimulate an immune response and kill tumor cells.
Checkpoint Inhibitor
Tremelimumab for Mesothelioma
This trial is testing a new cancer drug for people with mesothelioma who can't have surgery. 564 people will be enrolled and randomly assigned to either receive the drug or a placebo. There will be follow-ups to check safety and long-term effects.
Mesothelioma Clinical Trials With No Placebo
View 97 mesothelioma medical studies that do not have a placebo group.
CAR T-cell Therapy
TIL + Fludarabine + Cyclophosphamide for Advanced Solid Cancers
This trial is testing a new treatment for cancer that involves removing some lymph nodes, infusing the patient with their own tumor cells, and then giving them a high dose of aldesleukin. The goal is to see if this can help patients with locally advanced, recurrent, or metastatic cancer.
View More Mesothelioma Trials
See another 70 many medical studies focused on mesothelioma.
Frequently Asked Questions
Introduction to mesothelioma
What are the top hospitals conducting mesothelioma research?
When it comes to advancing treatment options for mesothelioma, certain hospitals have emerged as leaders in clinical trials. Memorial Sloan Kettering Cancer Center in New York has taken the lead with ten ongoing trials and a total of 25 trials dedicated to this rare cancer. Their first recorded mesothelioma trial dates back to 2006, showcasing their commitment to pushing boundaries in research. Meanwhile, Massachusettsr mesothelioma, certain hospitals have emerged as leaders in clinical trials. Memorial Sloan Kettering Cancer Center in New York has taken the lead with ten ongoing trials and a total of 25 trials dedicated to this rare cancer. Their first recorded mesothelioma trial dates back to 2006, showcasing their commitment to pushing boundaries in research. Meanwhile, Massachusetts General Hospital in Boston has been making notable strides with eight active trials and a history of 17 completed studies since initiating their first mesothelioma trial in 2004.
Heading south to Houston, MD Anderson Cancer Center stands out with seven active clinical trials focused on mesothelioma and a cumulative total of 14 trials conducted thus far. They began their journey into researching this challenging condition in 2007. Similarly, Dana Farber Cancer Institute shares the spotlight with seven ongoing mesothelioma trials and an impressive record of 13 previously conducted studies since launching their inaugural trial in 2009.
Lastly but certainly not least is Mayo Clinic located in Rochester which also shoulders responsibility by conducting seven concurrent clinical tests for patients living with mesothelioma while contributing towards eleven prior investigations; they embarked on this journey just six years ago from2015.Mesothelioma presents its unique challenges due to its rarity and aggressive nature; however, these top-tier hospitals are forging ahead through innovative research efforts aimed at improving outcomes for those affected by this deadly disease.
Through collaboration between medical professionals across different locations and specialties, advancements are being made every day that bring us closer to finding more effective treatments or even potential cures for mesothelioma. The dedication displayed by these leading institutions highlights our collective determination to combat this challenging cancer head-on
Which are the best cities for mesothelioma clinical trials?
When it comes to mesothelioma clinical trials, several cities stand out as major hubs for research and treatment. New York City leads the way with 39 active trials investigating treatments like INBRX-109, ASTX295, and gavo-cel. Houston, Texas is also a prominent location with 37 ongoing studies focused on interventions such as Intensity-Modulated Radiation Therapy and NGM831. Boston, Massachusettso mesothelioma clinical trials, several cities stand out as major hubs for research and treatment. New York City leads the way with 39 active trials investigating treatments like INBRX-109, ASTX295, and gavo-cel. Houston, Texas is also a prominent location with 37 ongoing studies focused on interventions such as Intensity-Modulated Radiation Therapy and NGM831. Boston, Massachusetts follows closely behind with 35 active trials exploring therapies like pembrolizumab and Lurbinectedin. Lastly, Los Angeles in California and Las Vegas in Nevada each offer 28 clinical trials examining various treatment approaches for mesothelioma patients. These cities provide individuals diagnosed with mesothelioma access to cutting-edge clinical trials that aim to improve outcomes and bring hope for better quality of life.
Which are the top treatments for mesothelioma being explored in clinical trials?
Mesothelioma, a challenging cancer to treat, is witnessing advancements in clinical trials as researchers explore potential breakthrough treatments. Leading the pack is pembrolizumab, with five active trials and an impressive 26 all-time mesothelioma trials since its introduction in 2015. Another contender making waves is LMB-100, which has shown promise with two ongoing trials and six total mesothelioma studies since its listing in 2016. Additionally, a pharmacological study has sparked interest with two active and three all-time mesothelioma trials recorded thus far. These innovative therapies offer hope for improved outcomes for patients battling this relentless disease.
What are the most recent clinical trials for mesothelioma?
Recent clinical trials for mesothelioma offer hope in the battle against this aggressive form of cancer. One promising trial is exploring a Part B Dose Expansion Combination, which aims to determine the effectiveness and safety of a new treatment approach for mesothelioma patients. Another study focuses on OT-101, investigating its potential benefits as a therapeutic option in mesothelioma cases. Additionally, researchers are evaluating the efficacy and tolerability of dose expansion strategies in solid tumors associated with mesothelioma. In another trial, magnesium sulfate is being investigated as a potential treatment option for managing symptoms related to this challenging disease. Furthermore, SynKIR-110 holds promise as an innovative therapy that could improve outcomes for those affected by mesothelioma. These recent clinical trials provide optimism and may pave the way towards more effective treatments for individuals battling this devastating condition.
What mesothelioma clinical trials were recently completed?
In the quest to combat mesothelioma, several clinical trials have recently concluded, showcasing significant progress in the field. Noteworthy among these is a trial sponsored by the University of Chicago that wrapped up in December 2021, examining the potential of Nivolumab as a treatment option. Another promising study was completed in July 2021 and focused on Magnesium Sulfate under the sponsorship of Dana-Farber Cancer Institute. Additionally, Epizyme, Inc., successfully completed a trial investigating Tazemetostat's efficacy against mesothelioma back in April 2020. These recent advancements highlight ongoing efforts to advance treatments for this challenging disease and offer hope to those affected by it.