Study Summary
This trial is testing a new drug, CPI-0209, to see if it's safe and effective in treating patients with advanced solid tumors and lymphomas. CPI-0209 is a small molecule inhibitor of EZH2.
- Mesothelioma
- T-Cell Lymphoma
- Advanced Solid Tumors
- Castration-resistant Prostate Cancer
- Non-Hodgkin's Lymphoma
Treatment Effectiveness
Study Objectives
2 Primary · 3 Secondary · Reporting Duration: 18 months
Trial Safety
Trial Design
8 Treatment Groups
Phase 2 Cohort M1
1 of 8
Phase 2 Cohort M4
1 of 8
Phase 2 Cohort M6
1 of 8
Phase 2: Combination Therapy
1 of 8
Phase 2 Cohort M5
1 of 8
Phase 2 Cohort M3
1 of 8
Phase 2 Cohort M2
1 of 8
Phase 2: Monotherapy
1 of 8
Experimental Treatment
213 Total Participants · 8 Treatment Groups
Primary Treatment: CPI-0209 · No Placebo Group · Phase 1 & 2
Trial Logistics
Trial Timeline
Who is running the clinical trial?
Eligibility Criteria
Age 18+ · All Participants · 8 Total Inclusion Criteria
Mark “Yes” if the following statements are true for you:Frequently Asked Questions
What are the conditions that CPI-0209 has been shown to be most effective against?
"CPI-0209 is most commonly used to treat malignant neoplasms of the pancreas. It can also be effective in treating other conditions like neoplasm metastasis, malignant neoplasm of stomach, and rhabdomyosarcoma." - Anonymous Online Contributor
Does CPI-0209 have a history of successful clinical trials?
"514 clinical trials have been completed for CPI-0209 since it was first studied in 2002 at Mayo Clinic. At the present moment, there are 275 active studies being conducted all over the world, with a notable concentration in Cincinnati, Ohio." - Anonymous Online Contributor
Are there any available positions for volunteers in this experiment?
"This research is ongoing, as indicated by the listing on clinicaltrials.gov. The original posting was on September 18th, 2019 with a most recent edit taking place on October 4th, 2022." - Anonymous Online Contributor
How many different medical clinics are participating in this study?
"Presently, there are 14 sites enrolling patients for this clinical trial. To name a few locations, these sites are in Cincinnati, New York and Chicago. If you participate in this trial, it is important to select the site nearest you to cut down on travel time." - Anonymous Online Contributor