Regadenoson for Heart Transplant Rejection
Trial Summary
What is the purpose of this trial?
The investigators will evaluate for early evidence of cardiac allograft dysfunction by cardiac MRI and single cell sequencing to determine underlying molecular and macroscopic causes.
Do I need to stop my current medications for the trial?
The trial information does not specify whether you need to stop taking your current medications. Please consult with the trial coordinators for more details.
Is Regadenoson generally safe for humans?
How does the drug Regadenoson differ from other treatments for heart transplant rejection?
Regadenoson is unique because it is primarily used as a stress agent in cardiac imaging, and its application for heart transplant rejection is novel. Unlike traditional immunosuppressive drugs like cyclosporine or prednisone, Regadenoson works by affecting blood flow and heart rate, which may offer a different approach to managing rejection.678910
Research Team
Paul Kim, MD
Principal Investigator
UC San Diego
Eligibility Criteria
This trial is for adults over 18 who had a heart transplant at least three months ago. It's not for those with recent heart issues, uncontrolled lung diseases like asthma or COPD, seizure history, recent organ rejection, certain heart rhythm problems, MRI contraindications (like pacemakers), severe kidney issues, past bad reactions to regadenoson or gadolinium contrast agents, extreme blood pressure or pulse rates.Inclusion Criteria
Exclusion Criteria
Timeline
Screening
Participants are screened for eligibility to participate in the trial
Baseline Assessment
Cardiac MRI and single cell sequencing are performed to evaluate cardiac allograft function
Follow-up
Participants are monitored for major adverse cardiovascular events (MACE) and other outcomes
Long-term Follow-up
Participants are monitored for long-term outcomes including stenotic microvasculopathy and MACE
Treatment Details
Interventions
- Regadenoson
Find a Clinic Near You
Who Is Running the Clinical Trial?
Paul Kim
Lead Sponsor