Drug Resistance Research for Osteosarcoma
What You Need to Know Before You Apply
What is the purpose of this trial?
This trial examines why some bone cancers, such as osteosarcoma, respond differently to drug treatments. Researchers aim to understand why certain tumors resist treatment and how high pressure inside tumors might affect drug effectiveness. They will also analyze blood samples to find clues about tumor behavior. Individuals who have had or will have a biopsy or surgery for bone or other solid tumors might be suitable candidates for this study. As an unphased trial, this study offers a unique opportunity to contribute to groundbreaking research that could improve future cancer treatments.
Will I have to stop taking my current medications?
The trial information does not specify whether you need to stop taking your current medications. It's best to discuss this with the trial coordinators or your doctor.
What prior data suggests that this study's methods are safe?
Research has shown that this study aims to understand how tumors respond to different drug treatments. The trial does not test new drugs on people, so no specific safety data exists for participants. Instead, the study examines tumor samples in the lab.
While there are no direct safety concerns for participants in this trial, it's important to note that it doesn't test a drug's effects on humans. Participants will provide tissue and blood samples, which are generally safe procedures with low risk.
Why are researchers excited about this trial?
Researchers are excited about this trial because it focuses on understanding drug resistance in osteosarcoma, a bone cancer that often affects teenagers and young adults. Unlike standard treatments such as surgery, chemotherapy, and radiation, this trial involves tissue procurement to study the cancer at a molecular level. By analyzing tumor tissues, researchers aim to uncover why some osteosarcoma cells become resistant to existing drugs. This could lead to the development of more effective, targeted therapies in the future, providing hope for patients who do not respond well to current treatment options.
What evidence suggests that this trial's treatments could be effective for osteosarcoma?
Research shows that osteosarcoma, a type of bone cancer, can sometimes stop responding to drug treatments, meaning the medicines that usually help no longer work. Studies suggest that high pressure inside tumors might be one reason for reduced drug effectiveness. In this trial, researchers will examine this pressure and other factors from tumor samples to better understand drug resistance. Although this study focuses on understanding tumors, it could lead to more effective treatments in the future.
Who Is on the Research Team?
John Healey, MD
Principal Investigator
Memorial Sloan Kettering Cancer Center
Are You a Good Fit for This Trial?
This trial is for individuals with a presumed or confirmed diagnosis of bone cancer (osteosarcoma) or other solid tumors who are undergoing biopsy or surgery. It's open to adults and minors; adults must consent, while minors give assent and have parental consent.Inclusion Criteria
Exclusion Criteria
Timeline for a Trial Participant
Screening
Participants are screened for eligibility to participate in the trial
Sample Collection
Tumor and blood samples are collected for laboratory analysis to study chemotherapy resistance and oncogenesis
Laboratory Analysis
Tumor samples are analyzed in vitro to determine chemotherapy resistance and correlate with clinical outcomes
Follow-up
Participants are monitored for safety and effectiveness after sample collection and analysis
What Are the Treatments Tested in This Trial?
Interventions
- NA
- Tissue Procurement
Find a Clinic Near You
Who Is Running the Clinical Trial?
Memorial Sloan Kettering Cancer Center
Lead Sponsor
Hospital for Special Surgery, New York
Collaborator
Weill Medical College of Cornell University
Collaborator
Columbia University
Collaborator
Rockefeller University
Collaborator