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CBD for Opioid Use Disorder
Study Summary
This trial will test if CBD can help reduce craving and anxiety in people abstaining from heroin. Brain scans will be taken before and after CBD administration to see how it affects neural circuits and transmitters.
Eligibility Criteria
Inclusion Criteria
You may be eligible if you check “Yes” for the criteria belowTimeline
Treatment Details
Study Objectives
Outcome measures can provide a clearer picture of what you can expect from a treatment.Trial Design
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- I am experiencing withdrawal symptoms from opioids.I am not using any reliable birth control methods.My kidney function or liver enzymes have never been more than twice the normal limit.You have significant physical health problems, such as trouble sleeping, difficulty communicating, mental health conditions, heart disease, abnormal heart rhythms, head injuries, or seizures.I am between 18 and 65 years old.I have been on methadone treatment of 40mg or more for over 14 days and have take-home doses.You recently took too much of a medication or drug, as determined by a doctor's evaluation.My drug screen may show substances other than THC or opioids, but I'm not actively using opioids or abusing cannabis.I am between 18 and 65 years old.I do not speak English.You have a disorder where you use heroin but are not currently seeking treatment. However, you have been abstinent from using heroin for at least 7 days before joining the study.I do not have any medical or mental health conditions that would prevent me from safely taking CBD.
- Group 1: Control
- Group 2: CBD 800mg
- Screening: It may take up to 3 Weeks to process to see if you qualify in this trial.
- Treatment: The duration you will receive the treatment varies.
- Follow Ups: You may be asked to continue sharing information regarding the trial for 6 Months after you stop receiving the treatment.
Frequently Asked Questions
Does this research endeavour currently accept participants?
"As of August 29th 2022, this clinical trial has ceased recruiting participants. Initially posted on November 12th 2020, the study is now inactive; nonetheless, there are still 1341 opioid abuse studies and 79 Cannabidiol (CBD) trials accepting patients."
How many participants are eligible for this trial?
"This trial is no longer enrolling participants, having first been posted on November 12th 2020 and last edited on August 29th 2022. As an alternative, there are 1341 trials for opioid abuse and 79 studies involving Cannabidiol (CBD) which are still recruiting patients."
What aims are scientists hoping to achieve through this clinical trial?
"This clinical trial will assess its primary outcome, a change in fMRI BOLD signal during restful connectivity, over two 30-minute MRI scans. Secondary objectives include assessing changes to cue-induced drug cravings (measured on the Visual Analogue Scale for Craving), Clinical Opiate Withdrawal Scores and anxiety levels (also measured using VAS) about 10 days after enrolling."
What are the eligibility requirements to take part in this research?
"This clinical trial is aimed at individuals who are afflicted with opioid abuse, and have an age between 18-65. An approximate of 200 patients will be accepted into this study."
What further studies have been conducted using Cannabidiol (CBD) as a basis?
"Presently, a total of 79 separate clinical trials are being conducted with 16 reaching Phase 3. These studies span across 290 locations worldwide yet the majority is centered around Ribeirao Preto in Sao Paulo."
Has the U.S. Food and Drug Administration granted clearance to Cannabidiol (CBD)?
"We rate Cannabidiol's safety at a 2, as there is evidence to suggest it has passed the initial testing phase but efficacy still needs to be proven."
Is the age range for this clinical trial inclusive of those over 35 years old?
"The requirements for accepting participants into this medical study are that they must be between 18 and 65 years of age."
Who else is applying?
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What portion of applicants met pre-screening criteria?
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