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Procedure

OCT-Guided Phototherapeutic Keratectomy for Corneal Opacity

N/A

Recruiting

Led By David Huang, MD, PhD

Research Sponsored by Oregon Health and Science University

Eligibility Criteria Checklist

Specific guidelines that determine who can or cannot participate in a clinical trial

Must have

Patients with vision primarily limited by superficial opacities and irregularities that could be removed by PTK while leaving at least 250 µm.

Be older than 18 years old

Timeline

Screening 3 weeks

Treatment Varies

Follow Up 12 months post-procedure

Awards & highlights

Study Summary

This trial will test whether using an OCT machine to guide a laser results in better vision for patients with corneal scars or defects.

Who is the study for?

This trial is for individuals with vision problems due to superficial corneal opacities and irregularities that can be treated with PTK, leaving at least 250 µm of the cornea. It's not suitable for those who can't stay still for OCT imaging, commit to follow-up visits, have deep corneal issues, or other eye conditions like cataracts or glaucoma.Check my eligibility

What is being tested?

The study tests if using OCT to guide laser settings improves vision in patients undergoing phototherapeutic keratectomy (PTK) for removing scars and defects on the front part of the cornea.See study design

What are the potential side effects?

Potential side effects may include discomfort in the eye, temporary visual disturbances, sensitivity to light, and a risk of infection or inflammation post-procedure.

Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below

Select...

My vision issues can potentially be corrected by a specific eye surgery.

Timeline

Screening ~ 3 weeks3 visits

Treatment ~ Varies

Follow Up ~ 12 months post-procedure

Screening ~ 3 weeks

Treatment ~ Varies

Follow Up ~12 months post-procedure

This trial's timeline: 3 weeks for screening, Varies for treatment, and 12 months post-procedure for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.

Primary outcome measures

Improvement in best spectacle-corrected visual acuity (BSCVA) after PTK

Secondary outcome measures

Improvement in uncorrected visual acuity (UCVA), refractive error, and higher order aberrations

Trial Design

1Treatment groups

Experimental Treatment

Group I: SurgeryExperimental Treatment1 Intervention

OCT is assisting in surgery guidance.

0 / 1Eligibility criteria met

Find a Location

Who is running the clinical trial?

Oregon Health and Science UniversityLead Sponsor

973 Previous Clinical Trials

6,845,949 Total Patients Enrolled

5 Trials studying Corneal Opacity

655 Patients Enrolled for Corneal Opacity

National Eye Institute (NEI)NIH

546 Previous Clinical Trials

1,401,848 Total Patients Enrolled

5 Trials studying Corneal Opacity

221 Patients Enrolled for Corneal Opacity

David Huang, MD, PhD5.01 ReviewsPrincipal Investigator - Casey Eye Institute, Oregon Health & Science University

Oregon Health and Science University

10 Previous Clinical Trials

2,847 Total Patients Enrolled

1 Trials studying Corneal Opacity

150 Patients Enrolled for Corneal Opacity

Media Library

OCT-guided laser phototherapeutic keratectomy (Procedure) Clinical Trial Eligibility Overview. Trial Name: NCT01243931 — N/A

Corneal Opacity Research Study Groups: Surgery

Corneal Opacity Clinical Trial 2023: OCT-guided laser phototherapeutic keratectomy Highlights & Side Effects. Trial Name: NCT01243931 — N/A

OCT-guided laser phototherapeutic keratectomy (Procedure) 2023 Treatment Timeline for Medical Study. Trial Name: NCT01243931 — N/A

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

What is the current scope of recruitment for this experiment?

"Affirmative. Clinicaltrials.gov shows that the experiment is still open for recruitment, with its initial posting date being June 1st 2011 and last updated on September 20th 2022. The research requires 80 participants to be sourced from one site in total."

Answered by AI

Are there any open enrolment opportunities in this experiment?

"Affirmative, the details published on clinicaltrials.gov affirms that this trial is actively looking for volunteers. The study was first announced in June 2011 and most recently revised in September 2022- it seeks to enrol 80 patients from a single centre."

Answered by AI

Recent research and studies

clinicaltrials.govStudy

Optical Coherence Tomography Guided Transepithelial Phototherapeutic Keratectomy

David Huang 2011. "Optical Coherence Tomography Guided Transepithelial Phototherapeutic Keratectomy". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT01243931.

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