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Virus Therapy

[18F]DPA714 PET Imaging for Brain Inflammation

Phase 2
Recruiting
Led By Asim Bag, MD
Research Sponsored by St. Jude Children's Research Hospital
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Participant is at least 8 years of age
Participants with histologically confirmed medulloblastoma and are scheduled to receive 36 Gy craniospinal irradiation
Timeline
Screening 3 weeks
Treatment Varies
Follow Up follow up 3: up to 2 years after radiation therapy
Awards & highlights

Study Summary

This trial is studying a brain inflammation marker called TSPO using a PET scan. They will also be doing MRI's to study microstructure damages caused by neuroinflammation in different parts of the brain.

Who is the study for?
This trial is for individuals at least 8 years old with confirmed medulloblastoma, scheduled for craniospinal irradiation. They must understand and sign consent forms, have specific TSPO gene binding sites (not low-affinity), and not require sedation for PET scans. Pregnant or lactating women and those with certain complications from previous surgeries are excluded.Check my eligibility
What is being tested?
[18F]DPA714 PET tracer is being tested to measure brain inflammation after whole brain radiation therapy in patients with brain tumors. The study will scan participants' brains multiple times over two years to assess changes in inflammation related to radiation doses received.See study design
What are the potential side effects?
Potential side effects may include discomfort from the injection of the radioactive tracer used during PET scans, reactions related to lying still during imaging procedures, and exposure to radiation beyond normal levels due to the imaging techniques.

Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below
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I am at least 8 years old.
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I have medulloblastoma and will get 36 Gy of radiation to my brain and spine.
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My genetic test shows I have a specific variant in the TSPO gene.

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~follow up 3: up to 2 years after radiation therapy
This trial's timeline: 3 weeks for screening, Varies for treatment, and follow up 3: up to 2 years after radiation therapy for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
SUVr

Trial Design

1Treatment groups
Experimental Treatment
Group I: ParticipantsExperimental Treatment1 Intervention
Participants who meet the eligibility criteria in the study will receive Translocation Protein (TSPO) Positron Emission Tomography (PET) for longitudinal, quantitative assessment of brain neuroinflammation following whole brain radiation therapy.

Find a Location

Who is running the clinical trial?

St. Jude Children's Research HospitalLead Sponsor
427 Previous Clinical Trials
5,306,555 Total Patients Enrolled
13 Trials studying Medulloblastoma
2,874 Patients Enrolled for Medulloblastoma
Asim Bag, MDPrincipal InvestigatorSt. Jude Children's Research Hospital
1 Previous Clinical Trials
5 Total Patients Enrolled

Media Library

[18F]DPA714 (Virus Therapy) Clinical Trial Eligibility Overview. Trial Name: NCT05128903 — Phase 2
Medulloblastoma Research Study Groups: Participants
Medulloblastoma Clinical Trial 2023: [18F]DPA714 Highlights & Side Effects. Trial Name: NCT05128903 — Phase 2
[18F]DPA714 (Virus Therapy) 2023 Treatment Timeline for Medical Study. Trial Name: NCT05128903 — Phase 2

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Who qualifies to register for this medical research project?

"This clinical trial seeks out 22 participants between the ages of 8 and 39 who are suffering from medulloblastoma. Principally, candidates must be at least 8 years old to qualify."

Answered by AI

Is this research initiative welcoming elderly participants?

"The criteria for participation in this trial stipulates that all candidates must fall between 8 and 39 years of age."

Answered by AI

Is there an opportunity to participate in this experiment for those seeking treatment?

"Affirmative. According to records posted on clinicaltrials.gov, this medical research is still recruiting participants since its inception on July 5th 2022. The study is looking for 22 individuals at a single location."

Answered by AI

To what extent could [18F]DPA714 potentially harm patients?

"Analysts working for Power have rated [18F]DPA714 a 2 on their safety scale, as there is some research indicating its security but no evidence of effectiveness from Phase 2 trials."

Answered by AI

How many individuals are actively engaging in this research project?

"Affirmative. According to the information hosted on clinicaltrials.gov, this medical study is currently recruiting volunteers. It was first posted on July 5th 2022 and last updated on August 17th 2022 with a goal of obtaining 22 participants from one site."

Answered by AI
~10 spots leftby Oct 2025