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Procedure

Tissue Preservation for Glioblastoma

N/A
Waitlist Available
Led By Alireza Mohammadi, MD
Research Sponsored by Case Comprehensive Cancer Center
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Be older than 18 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up 1 year
Awards & highlights

Study Summary

This trial is testing if taking multiple samples of a brain tumor during surgery can help researchers understand the changes that occur in the tumor cells.

Who is the study for?
This trial is for individuals with a high-grade brain tumor called glioblastoma, visible on MRI scans. They must have a significant amount of tumor tissue (at least 15 cc), be in good physical condition (Karnofsky score ≥70), and have normal blood, kidney, and coagulation lab values. Pregnant individuals or those with conditions that could affect the study's outcome are excluded.Check my eligibility
What is being tested?
The trial is using the NICO Myriad device and Tissue Preservation System to collect multiple samples from different areas of brain tumors during surgery. The goal is to understand how mutations vary within the tumor which may improve diagnosis and treatment strategies.See study design
What are the potential side effects?
While specific side effects aren't listed for this procedure-focused trial, potential risks may include typical surgical complications such as infection, bleeding, reaction to anesthesia, or changes in brain function.

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~1 year
This trial's timeline: 3 weeks for screening, Varies for treatment, and 1 year for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Feasibility, as measured by percentage of the sample deemed viable by flow cytometry
Other outcome measures
DNA methylation status in tumor regions
Gene expression in tumor regions
Number of somatic mutations per region

Trial Design

1Treatment groups
Experimental Treatment
Group I: Tissue Preservation System (TPS)Experimental Treatment1 Intervention
Tumor tissue will be obtained, processed, and then transported remotely to undergo multiple tests, including gene panel DNA sequencing, DNA methylation array, and bulk as well as single-cell transcriptome analyses (RNA-seq)

Find a Location

Who is running the clinical trial?

Case Comprehensive Cancer CenterLead Sponsor
452 Previous Clinical Trials
31,892 Total Patients Enrolled
15 Trials studying Glioblastoma
428 Patients Enrolled for Glioblastoma
Alireza Mohammadi, MDPrincipal InvestigatorCleveland Clinic Taussig Cancer institute, Case Comprehensive Cancer Center

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.
Recent research and studies
clinicaltrials.govStudy
Improving Understanding of Brain Tumors Through Preservation of Biologically Active Brain Tissue
2020. "Improving Understanding of Brain Tumors Through Preservation of Biologically Active Brain Tissue". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT04545177.
All > Brain Tumor
~4 spots leftby Apr 2025
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