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18F-TFB PET Imaging for Thyroid Cancer
N/A
Waitlist Available
Led By Ravinder Grewal, MD
Research Sponsored by Memorial Sloan Kettering Cancer Center
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial Must have
Age ≥ 18 years
Patients must have histologically or cytologically confirmed thyroid carcinoma of follicular origin (including papillary and its respective variants)
Timeline
Screening 3 weeks
Treatment Varies
Follow Up up to 2 day following scan
Awards & highlights
Study Summary
This trial is testing a new imaging method to see if it can more quickly than the current standard predict whether radioactive iodine will be taken up by thyroid cancer cells. This would help with treatment planning.
Who is the study for?
This trial is for adults over 18 with thyroid cancer of follicular origin, who can sign consent and follow a low iodine diet. They must have normal organ function, not be pregnant or breastfeeding, use contraception if fertile, and have tumors visible on imaging tests. Exclusion includes uncontrolled illness, recent iodinated contrast exposure without clearance, and non-compliance.Check my eligibility
What is being tested?
The study tests a new PET imaging technique using 18F-Tetrafluoroborate (18F-TFB) to predict radioactive iodine uptake in thyroid cancer more quickly than current methods without affecting therapeutic radioactive iodine uptake.See study design
What are the potential side effects?
While the trial description does not specify side effects of the intervention directly, typical PET scan-related side effects may include discomfort at injection site or allergic reaction to tracers.
Eligibility Criteria
Inclusion Criteria
You may be eligible if you check “Yes” for the criteria belowSelect...
I am 18 years old or older.
Select...
My thyroid cancer is confirmed to be of follicular origin, including papillary types.
Select...
I can take care of myself but might not be able to do heavy physical work.
Timeline
Screening ~ 3 weeks3 visits
Treatment ~ Varies
Follow Up ~ up to 2 day following scan
Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~up to 2 day following scan
Treatment Details
Study Objectives
Outcome measures can provide a clearer picture of what you can expect from a treatment.Primary outcome measures
Safety Outcome Measures (CTCAE v4) severity of adverse events
Trial Design
1Treatment groups
Experimental Treatment
Group I: PET Imaging With 18F-TFBExperimental Treatment2 Interventions
The intervention is the administration of a single dose of approximately 5-10 mCi 18F-TFB (mass <= 50 μg) for imaging purposes. This will be followed by a 30 minute dynamic PET/CT study immediately after injection, at 60 minutes (+/- 10 min) and 4 hours (+/- 15 min) post injection. The second and third scan will last up to 30 minutes.
Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
PET Imaging
2008
Completed Phase 3
~380
Find a Location
Who is running the clinical trial?
Memorial Sloan Kettering Cancer CenterLead Sponsor
1,934 Previous Clinical Trials
588,805 Total Patients Enrolled
Ravinder Grewal, MDPrincipal InvestigatorMemorial Sloan Kettering Cancer Center
4 Previous Clinical Trials
90 Total Patients Enrolled
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Eligibility Criteria:
This trial includes the following eligibility criteria:- I am not pregnant or cannot become pregnant.I had a CT scan with dye within the last 3 months but my body has cleared the iodine.My organs and bone marrow are functioning normally.I am 18 years old or older.I will use birth control during and for 6 months after treatment, as my doctor advises.I cannot follow a low iodine diet or need medication high in iodide.My thyroid cancer is confirmed to be of follicular origin, including papillary types.I can take care of myself but might not be able to do heavy physical work.I do not have any ongoing illnesses or social situations that would prevent me from following the study's requirements.You should have tumors that can be seen on a PET scan, ultrasound, CT scan, or MRI.
Research Study Groups:
This trial has the following groups:- Group 1: PET Imaging With 18F-TFB
Awards:
This trial has 1 awards, including:- No Placebo-Only Group - All patients enrolled in this study will receive some form of active treatment.
Timeline:
This trial has the following timeline:- Screening: It may take up to 3 Weeks to process to see if you qualify in this trial.
- Treatment: The duration you will receive the treatment varies.
- Follow Ups: You may be asked to continue sharing information regarding the trial for 6 Months after you stop receiving the treatment.
Frequently Asked Questions
These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.
Is this medical experiment in need of new participants?
"The clinicaltrials.gov database indicates that this medical research is no longer recruiting patients and has not been since June 2, 2022; the trial had originally begun June 16, 2017. However, there are 231 other trials still actively seeking participants at present."
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