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SSPG Test + Adipose Tissue Biopsy for Post-COVID Syndrome
N/A
Waitlist Available
Research Sponsored by Stanford University
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial Must have
Ages 18 to 80
Be older than 18 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up 2 years
Awards & highlights
Study Summary
This trial investigates how obesity, insulin resistance and fat tissue infection may contribute to long-term COVID-19 effects, and whether new or existing treatments can target these pathways.
Who is the study for?
This trial is for adults aged 18 to 80 with a BMI of at least 25 kg/m2, who are not pregnant. It's not for those with high blood pressure, recent significant weight change, fasting glucose >=126 mg/dL, psychiatric disorders, bleeding or major organ diseases, diabetes, history of liposuction or bariatric surgery, and those on certain medications.Check my eligibility
What is being tested?
The study is examining how obesity and insulin resistance might affect long-term COVID-19 symptoms by testing fat tissue's role in chronic inflammation or as a virus reservoir. Participants will undergo an SSPG test and some may have an adipose tissue biopsy.See study design
What are the potential side effects?
Potential side effects from the procedures could include discomfort at the biopsy site for those undergoing adipose tissue sampling. The SSPG test generally has minimal risks associated but may cause discomfort similar to routine blood tests.
Eligibility Criteria
Inclusion Criteria
You may be eligible if you check “Yes” for the criteria belowSelect...
I am between 18 and 80 years old.
Timeline
Screening ~ 3 weeks3 visits
Treatment ~ Varies
Follow Up ~ 2 years
Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~2 years
Treatment Details
Study Objectives
Outcome measures can provide a clearer picture of what you can expect from a treatment.Primary outcome measures
Concentration of Viral RNA in Adipose Tissue
Rate of Inflammatory Gene Expression in Adipose Tissue
Rate of Inflammatory Response
+1 moreTrial Design
3Treatment groups
Experimental Treatment
Active Control
Group I: Healthy Controls OnlyExperimental Treatment2 Interventions
We are looking for 20 healthy controls for 2 in-person visits on separate days.
An Insulin Sensitivity Test (SSPG: Steady State Plasma Glucose) is performed to determine if the participant is insulin-sensitive or insulin resistant.
A Needle Fat Biopsy: After an overnight fast, approximately 1-2 grams of subcutaneous fat will be removed by a needle. Patients will have a local anesthetic prior to the procedure.
Group II: COVID infected and healthy controlsExperimental Treatment1 Intervention
Participants will perform a needle fat biopsy for tissue harvesting in the subacute phase (15-30d) of Covid-19 infection or as a healthy control. Our goal is 20 COVID-19 infected participants and 10 healthy controls.
Group III: Chart Review (not actively recruiting)Active Control1 Intervention
Chart review of previously consented participants from the entire NIH RECOVER cohort, comprised of 15,000 infected and 2,600 noninfected patients across the country.
Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
Adipose Tissue Biopsy
2015
N/A
~120
Find a Location
Who is running the clinical trial?
Stanford UniversityLead Sponsor
2,386 Previous Clinical Trials
17,333,953 Total Patients Enrolled
30 Trials studying Insulin Resistance
2,415 Patients Enrolled for Insulin Resistance
Media Library
Eligibility Criteria:
This trial includes the following eligibility criteria:- I have never had weight loss surgery.You weigh more than what is considered healthy for your height.I am not using weight loss medication or oral steroids.If you have gained or lost a lot of weight in the last 12 weeks, you cannot participate as a healthy control in Arm 3.You have gained or lost a lot of weight in the past month.I have never had liposuction.I have never had liposuction.I do not have any major organ diseases.I do not have diabetes.I am not taking any blood thinners.I am between 18 and 80 years old.If you are a healthy volunteer, you won't be included if your fasting glucose level is higher than 126 mg/dL.I do not have a bleeding disorder.If you are a healthy control, you cannot have a hematocrit level lower than 33%.
Research Study Groups:
This trial has the following groups:- Group 1: Healthy Controls Only
- Group 2: Chart Review (not actively recruiting)
- Group 3: COVID infected and healthy controls
Awards:
This trial has 1 awards, including:- No Placebo-Only Group - All patients enrolled in this study will receive some form of active treatment.
Timeline:
This trial has the following timeline:- Screening: It may take up to 3 Weeks to process to see if you qualify in this trial.
- Treatment: The duration you will receive the treatment varies.
- Follow Ups: You may be asked to continue sharing information regarding the trial for 6 Months after you stop receiving the treatment.
Frequently Asked Questions
These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.
Can individuals aged 40 or above participate in this trial?
"This medical trial is open to patients between 18 and 80 years old, with 29 trials specifically targeting sub-18s and 135 aimed at those over 65."
Answered by AI
What type of individual is most suitable to take part in this experiment?
"This clinical trial is in search of 55 participants that meet the criteria of insulin resistance and age range between 18 to 80 years old."
Answered by AI
Is enrollment for this clinical investigation currently open?
"According to information found on clinicaltrials.gov, this trial is not currently enrolling any candidates - the last update was made on April 26th 2023. Fortunately, there are 214 other medical trials actively searching for participants at this moment in time."
Answered by AI
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