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Exercise for Weight Loss (WAX Trial)

N/A
Recruiting
Led By Jeffrey Horowitz, PhD
Research Sponsored by University of Michigan
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Age: 18-40
Women must have regularly occurring menses and must be premenopausal
Timeline
Screening 3 weeks
Treatment Varies
Follow Up 6 months
Awards & highlights

WAX Trial Summary

This trial is investigating how weight loss & exercise together affect abdominal fat tissue & potential health benefits. Involvement is 10-13 months.

Who is the study for?
This trial is for premenopausal women aged 18-40 with a BMI of 30-40, who have stable weight and don't regularly exercise. It's not for those pregnant, lactating, with heart disease or metabolic diseases like diabetes, on certain medications affecting metabolism, using tobacco products, or with allergies to specific drugs.Check my eligibility
What is being tested?
The study tests how adding moderate intensity continuous training (MICT) exercise affects fat tissue and metabolic health during a weight loss program compared to no exercise. Participants will undergo metabolic testing before, during and after achieving a 10% weight loss.See study design
What are the potential side effects?
Since the interventions involve diet control and MICT exercises like walking or cycling at a steady pace, side effects may include typical physical activity-related issues such as muscle soreness or fatigue.

WAX Trial Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below
Select...
I am between 18 and 40 years old.
Select...
I am a woman who has regular periods and am not in menopause.

WAX Trial Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~6 months
This trial's timeline: 3 weeks for screening, Varies for treatment, and 6 months for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Adipose tissue capillarization
Adipose tissue fibrosis
Fatty acid turnover
+1 more
Secondary outcome measures
Body fat mass
Body weight change
Oral Glucose Tolerance Test (OGTT)

WAX Trial Design

2Treatment groups
Experimental Treatment
Group I: No exercise (Control)Experimental Treatment1 Intervention
to remain sedentary (no planned physical exercise) throughout the duration of the 10% weight loss phase of the study
Group II: Moderate Intensity Continuous Training (MICT) exercise groupExperimental Treatment1 Intervention
45 minutes of continuous steady-state exercise at 70% maximal heart rate throughout the 10% weight loss phase of the study

Find a Location

Who is running the clinical trial?

University of MichiganLead Sponsor
1,797 Previous Clinical Trials
6,377,990 Total Patients Enrolled
4 Trials studying Metabolic Diseases
283 Patients Enrolled for Metabolic Diseases
Jeffrey Horowitz, PhDPrincipal InvestigatorUniversity of Michigan
1 Previous Clinical Trials
36 Total Patients Enrolled

Media Library

MICT Exercise Clinical Trial Eligibility Overview. Trial Name: NCT05806801 — N/A
Metabolic Diseases Research Study Groups: Moderate Intensity Continuous Training (MICT) exercise group, No exercise (Control)
Metabolic Diseases Clinical Trial 2023: MICT Exercise Highlights & Side Effects. Trial Name: NCT05806801 — N/A
MICT Exercise 2023 Treatment Timeline for Medical Study. Trial Name: NCT05806801 — N/A
Metabolic Diseases Patient Testimony for trial: Trial Name: NCT05806801 — N/A

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Is this investigation open to participants over an octogenarian age?

"The age-based criteria for inclusion in this trial outlines that potential participants must be between 18 and 40 years old."

Answered by AI

How many participants are being tracked for this research project?

"Affirmative. According to information posted on clinicaltrials.gov, this experiment commenced recruitment on April 1st 2023 and was most recently updated in late March of the same year. The research team is hoping to find 70 individuals across one medical centre for participation."

Answered by AI

Am I able to participate in this experiment?

"In order to qualify for this clinical trial, an individual must have obesity and fall within the bracketed ages of 18-40. Currently, 70 participants are needed for the study."

Answered by AI

Is this clinical investigation presently enrolling participants?

"Affirmative. Clinicaltrials.gov suggests that this research project, which was first shared on April 1st 2023, is searching for participants. Approximately 70 patients must be recruited from one medical site."

Answered by AI

Who else is applying?

What state do they live in?
Michigan
What site did they apply to?
University of Michigan
University of Michigan School of Kinesiology
What portion of applicants met pre-screening criteria?
Did not meet criteria
Met criteria
How many prior treatments have patients received?
0

Why did patients apply to this trial?

To help with diabetes help. I am overweight and have been losing weight but have started to plateau and I am interested in seeing how changes could help.
PatientReceived 1 prior treatment

What questions have other patients asked about this trial?

How long does the trial take?
PatientReceived no prior treatments
Recent research and studies
clinicaltrials.govStudy
Metabolic Adaptations to Weight Loss With and Without Exercise
Jeffrey F Horowitz 2023. "Metabolic Adaptations to Weight Loss With and Without Exercise". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT05806801.
All > Metabolic Syndrome > Weight Loss
~45 spots leftby Aug 2027
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